Results 1 to 10 of about 41,265 (311)

Synthesis, Biological Evaluation, and In Silico Studies of New Acetylcholinesterase Inhibitors Based on Quinoxaline Scaffold

Molecules, 2021
A quinoxaline scaffold exhibits various bioactivities in pharmacotherapeutic interests. In this research, twelve quinoxaline derivatives were synthesized and evaluated as new acetylcholinesterase inhibitors.
Paptawan Suwanhom, Jirakrit Saetang, Pasarat Khongkow, Teerapat Nualnoi, Varomyalin Tipmanee, Luelak Lomlim   +5 more
doaj   +2 more sources

Quinoxaline Moiety: A Potential Scaffold against Mycobacterium tuberculosis

Molecules, 2021
Background. The past decades have seen numerous efforts to develop new antitubercular agents. Currently, the available regimens are lengthy, only partially effective, and associated with high rates of adverse events. The challenge is therefore to develop
Marc Montana, Vincent Montero, Omar Khoumeri, Patrice Vanelle   +3 more
doaj   +2 more sources

Quinoxaline: A comprehension of current pharmacological advancement in medicinal chemistry

European Journal of Medicinal Chemistry Reports, 2022
Quinoxaline is a fused heterocycle ring template present in diverse pharmacophore and widely used in medicinal chemistry. Owing to its vast pharmaceutical profile, several quinoxalines analogous displayed their distinct pharmacological activities. In the
Suresh Kumar Suthar, Narendra Singh Chundawat, Girdhar Pal Singh, José M. Padrón, Yuvraj Kunwar Jhala   +4 more
doaj   +2 more sources

Push–Pull Derivatives Based on 2,4′-Biphenylene Linker with Quinoxaline, [1,2,5]Oxadiazolo[3,4-B]Pyrazine and [1,2,5]Thiadiazolo[3,4-B]Pyrazine Electron Withdrawing Parts

Molecules, 2022
A series of novel V-shaped quinoxaline, [1,2,5]oxadiazolo[3,4-b]pyrazine and [1,2,5]thiadiazolo[3,4-b]pyrazine push–pull derivatives with 2,4′-biphenylene linker were designed and their electrochemical, photophysical and nonlinear optical properties were
Egor V. Verbitskiy, Pascal le Poul, Filip Bureš, Sylvain Achelle, Alberto Barsella, Yuriy A. Kvashnin, Gennady L. Rusinov, Valery N. Charushin   +7 more
doaj   +2 more sources

Quinoxaline Derivatives as Antiviral Agents: A Systematic Review

Molecules, 2020
Background: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen.
Marc Montana, Vincent Montero, Omar Khoumeri, Patrice Vanelle   +3 more
doaj   +2 more sources

Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides

Applied Sciences, 2021
Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of considerable interest in medicinal chemistry, as it exhibits a wide range of
Ali Irfan, Sajjad Ahmad, Saddam Hussain, Fozia Batool, Haseeba Riaz, Rehman Zafar, Katarzyna Kotwica-Mojzych, Mariusz Mojzych   +7 more
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Synthesis and biological activity of some heterocyclic compounds containing quinoxaline and coumarin moieties [PDF]

Journal of the Serbian Chemical Society, 2000
2,3-Dichloroquinoxaline (2) condensed with 7,8-dihydroxy-4-methylcoumarin to give the 1,4-dioxane derivative 4. 2.3-Dichloroquinoxaline (2) reacted with 4-hydroxycoumarin, 7-hydroxy-4-methylcoumarin and acyl hydrazide 13 to give either the 2,3 ...
M. E. ABD EL-FATTAH, I. M. EL-DEEN
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Induction of Cell Death in Human A549 Cells Using 3-(Quinoxaline-3-yl) Prop-2-ynyl Methanosulphonate and 3-(Quinoxaline-3-yl) Prop-2-yn-1-ol

Molecules, 2019
Despite major advancements in the development of various chemotherapeutic agents, treatment for lung cancer remains costly, ineffective, toxic to normal non-cancerous cells, and still hampered by a high level of remissions.
Mixo Aunny Sibiya, Lerato Raphoko, Dikgale Mangokoana, Raymond Makola, Winston Nxumalo, Thabe Moses Matsebatlela   +5 more
doaj   +2 more sources

Eco-friendly approach to access of quinoxaline derivatives using nanostructured pyrophosphate Na2PdP2O7 as a new, efficient and reusable heterogeneous catalyst

BMC Chemistry, 2020
In the present study, we report the synthesis of various quinoxaline derivatives from direct condensation of substituted aromatic 1,2-diamine with 1,2-dicarbonyl catalyzed by nanostructured pyrophosphate Na2PdP2O7 as a new highly efficient ...
Karim Dânoun, Younes Essamlali, Othmane Amadine, Hassan Mahi, Mohamed Zahouily   +4 more
doaj   +2 more sources

Cinnamil- and Quinoxaline-Derivative Indicator Dyes for Detecting Volatile Amines in Fish Spoilage

Molecules, 2019
Colorimetric indicators are versatile for applications such as intelligent packaging. By interacting with food, package headspace, and/or the ambient environment, color change in these indicators can be useful for reflecting the actual quality and/or ...
Xiaoyu Luo, Loong-Tak Lim
doaj   +2 more sources