Results 1 to 10 of about 9,522 (99)

Synthesis and biological activity of some heterocyclic compounds containing quinoxaline and coumarin moieties [PDF]

Journal of the Serbian Chemical Society, 2000
2,3-Dichloroquinoxaline (2) condensed with 7,8-dihydroxy-4-methylcoumarin to give the 1,4-dioxane derivative 4. 2.3-Dichloroquinoxaline (2) reacted with 4-hydroxycoumarin, 7-hydroxy-4-methylcoumarin and acyl hydrazide 13 to give either the 2,3 ...
M. E. ABD EL-FATTAH, I. M. EL-DEEN
doaj   +2 more sources

Analgesic and anti-inflammatory activity of quinoxaline derivatives: Design synthesis and characterization

Results in Chemistry, 2023
Medicinal chemistry is a basic science that involves identification, synthesis and development of new drugs for therapeutic use. Biological importance of heterocycles makes them more crucial in pharmaceutical industries.In this work heterocyclics like ...
Geethavani Meka, Ramakrishna Chintakunta
doaj   +1 more source

Synthesis, Biological Evaluation, and In Silico Studies of New Acetylcholinesterase Inhibitors Based on Quinoxaline Scaffold

Molecules, 2021
A quinoxaline scaffold exhibits various bioactivities in pharmacotherapeutic interests. In this research, twelve quinoxaline derivatives were synthesized and evaluated as new acetylcholinesterase inhibitors.
Paptawan Suwanhom, Jirakrit Saetang, Pasarat Khongkow, Teerapat Nualnoi, Varomyalin Tipmanee, Luelak Lomlim   +5 more
doaj   +1 more source

Quinoxaline Moiety: A Potential Scaffold against Mycobacterium tuberculosis

Molecules, 2021
Background. The past decades have seen numerous efforts to develop new antitubercular agents. Currently, the available regimens are lengthy, only partially effective, and associated with high rates of adverse events. The challenge is therefore to develop
Marc Montana, Vincent Montero, Omar Khoumeri, Patrice Vanelle   +3 more
doaj   +1 more source

Density Functional Theory and Quantitative Structure-Activity Relationship Studies of some Quinoxaline derivatives as potential Corrosion Inhibitors for Copper in Acidic Medium

International Journal of Electrochemical Science, 2012
Density Functional Theory (DFT) using the B3LYP functional and Quantitative Structure-Activity Relationship QSAR studies is reported on some quinoxaline derivatives namely 3-methyl-2-phenyl quinoxaline (MPQ), 2,3-diphenyl quinoxaline (PPQ), 3-methyl-2(2 ...
Mwadham M. Kabanda, Eno E. Ebenso
doaj   +1 more source

A High-Throughput Screening Method for Determining the Optimized Synthesis Conditions of Quinoxaline Derivatives Using Microdroplet Reaction

Frontiers in Chemistry, 2020
Quinoxaline derivatives demonstrate many distinguished chemical, biological, and physical properties and have a wide application in dyes, electroluminescent material, organic semiconductors, biological agents, etc.
Yanmei Yang, Junmin Liu, Zhenzhen Chen, Weihua Niu, Ran Li, Le Niu, Peng Yang, Xiaoyan Mu, Bo Tang   +8 more
doaj   +1 more source

Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides

Applied Sciences, 2021
Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of considerable interest in medicinal chemistry, as it exhibits a wide range of
Ali Irfan, Sajjad Ahmad, Saddam Hussain, Fozia Batool, Haseeba Riaz, Rehman Zafar, Katarzyna Kotwica-Mojzych, Mariusz Mojzych   +7 more
doaj   +1 more source

Induction of Cell Death in Human A549 Cells Using 3-(Quinoxaline-3-yl) Prop-2-ynyl Methanosulphonate and 3-(Quinoxaline-3-yl) Prop-2-yn-1-ol

Molecules, 2019
Despite major advancements in the development of various chemotherapeutic agents, treatment for lung cancer remains costly, ineffective, toxic to normal non-cancerous cells, and still hampered by a high level of remissions.
Mixo Aunny Sibiya, Lerato Raphoko, Dikgale Mangokoana, Raymond Makola, Winston Nxumalo, Thabe Moses Matsebatlela   +5 more
doaj   +1 more source

Synthesis, characterization, and biological target prediction of novel 1,3-dithiolo[4,5-b]quinoxaline and thiazolo[4,5-b]quinoxaline derivatives

Heterocyclic Communications, 2023
Quinoxalines are a family of nitrogen-based heterocyclic compounds that have garnered much interest because of their wide range of applications. 2,3-Dichloroquinoxaline is an aromatic molecule that frequently serves as a synthetic intermediate in ...
El-Gaby Mohamed S. A., Ammar Yousry A., Ismail Mostafa A., Ragab Ahmed, Abusaif Moustafa S.   +4 more
doaj   +1 more source

Synthesis, Characterization and Protonation Behavior of Quinoxaline-Fused Porphycenes

Molecules, 2017
9,10-Quinoxaline-fused porphycenes 1a-H2 and 1b-H2 were synthesized by intramolecular McMurry coupling. As a result of the annulation of the quinoxaline moiety on the porphycene skeleton, 1a-H2 and 1b-H2 display absorption and fluorescence in the near ...
Daiki Kuzuhara, Mika Sakaguchi, Wataru Furukawa, Takuya Okabe, Naoki Aratani, Hiroko Yamada   +5 more
doaj   +1 more source