Results 1 to 10 of about 29,062 (270)

Synthesis and biological activity of some heterocyclic compounds containing quinoxaline and coumarin moieties [PDF]

Journal of the Serbian Chemical Society, 2000
2,3-Dichloroquinoxaline (2) condensed with 7,8-dihydroxy-4-methylcoumarin to give the 1,4-dioxane derivative 4. 2.3-Dichloroquinoxaline (2) reacted with 4-hydroxycoumarin, 7-hydroxy-4-methylcoumarin and acyl hydrazide 13 to give either the 2,3 ...
M. E. ABD EL-FATTAH, I. M. EL-DEEN
doaj   +4 more sources

Synthesis, molecular modelling, and biological evaluation of novel quinoxaline derivatives for treating type II diabetes [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Quinoxalines are benzopyrazine derivatives with significant therapeutic impact in the pharmaceutical industry. They proved to be useful against inflammation, bacterial, fungal, viral infection, diabetes and other applications.
Fatmah Ali S. Alasmary, Dalal A. Abdullah, Vijay H. Masand, Abir Ben Bacha, Abdelsattar Mansour Omar Ebeid, Moustafa E. El-Araby, Ahmed M Alafeefy   +6 more
doaj   +2 more sources

A Selective MAP3K1 Inhibitor Facilitates Discovery of NPM1 as a Member of the Network [PDF]

Molecules
The quinoxaline core is found in several biologically active compounds, with Erdafitinib being the first FDA-approved quinoxaline derivative that targets a kinase and exhibits anti-cancer properties.
Lidia Boghean, Sarbjit Singh, Kiran K. Mangalaparthi, Smitha Kizhake, Lelisse Umeta, Donn Wishka, Paul Grothaus, Akhilesh Pandey, Amarnath Natarajan   +8 more
doaj   +2 more sources

Compounds Containing 2,3‐Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin‐Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms [PDF]

MicrobiologyOpen
Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3‐N,N‐diphenyl quinoxaline derivatives against Gram‐positive, Gram‐negative, and Mycobacterium species ...
Gilda Padalino, Katrina Duggan, Luis A. J. Mur, Jean‐Yves Maillard, Andrea Brancale, Karl F. Hoffmann   +5 more
doaj   +2 more sources

Molecular Interlayer for High-Performance and Stable 2D Tin Halide Perovskite Transistor. [PDF]

Adv Sci (Weinh)
Molecular interlayers are designed for p‐channel 2D Sn halide thin‐film transistors, yielding exceptional performance metrics, a significant reduction in hysteresis, and enhanced ambient stability. The effectiveness of new molecular interlayers (TPOF1, TPOF2, and 2F‐TOPF2) is confirmed by surface treatment, demonstrating remarkable carrier mobility ...
Jeong BH, Prayogo JA, Lee J, Lee SW, Whang DR, Chang DW, Park HJ.   +6 more
europepmc   +2 more sources

Synthesis, Biological Evaluation, and In Silico Studies of New Acetylcholinesterase Inhibitors Based on Quinoxaline Scaffold

Molecules, 2021
A quinoxaline scaffold exhibits various bioactivities in pharmacotherapeutic interests. In this research, twelve quinoxaline derivatives were synthesized and evaluated as new acetylcholinesterase inhibitors.
Paptawan Suwanhom, Jirakrit Saetang, Pasarat Khongkow, Teerapat Nualnoi, Varomyalin Tipmanee, Luelak Lomlim   +5 more
doaj   +1 more source

A High-Throughput Screening Method for Determining the Optimized Synthesis Conditions of Quinoxaline Derivatives Using Microdroplet Reaction

Frontiers in Chemistry, 2020
Quinoxaline derivatives demonstrate many distinguished chemical, biological, and physical properties and have a wide application in dyes, electroluminescent material, organic semiconductors, biological agents, etc.
Yanmei Yang, Junmin Liu, Zhenzhen Chen, Weihua Niu, Ran Li, Le Niu, Peng Yang, Xiaoyan Mu, Bo Tang   +8 more
doaj   +1 more source

Quinoxaline Moiety: A Potential Scaffold against Mycobacterium tuberculosis

Molecules, 2021
Background. The past decades have seen numerous efforts to develop new antitubercular agents. Currently, the available regimens are lengthy, only partially effective, and associated with high rates of adverse events. The challenge is therefore to develop
Marc Montana, Vincent Montero, Omar Khoumeri, Patrice Vanelle   +3 more
doaj   +1 more source

Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA [PDF]

, 1987
Forms of the DNA double helix containing non-Watson-Crick base-pairing have been discovered recently based on x-ray diffraction analysis of quinoxaline antibiotic-oligonucleotide complexes.
Dervan, Peter B., Mendel, David
core   +2 more sources

Induction of Cell Death in Human A549 Cells Using 3-(Quinoxaline-3-yl) Prop-2-ynyl Methanosulphonate and 3-(Quinoxaline-3-yl) Prop-2-yn-1-ol

Molecules, 2019
Despite major advancements in the development of various chemotherapeutic agents, treatment for lung cancer remains costly, ineffective, toxic to normal non-cancerous cells, and still hampered by a high level of remissions.
Mixo Aunny Sibiya, Lerato Raphoko, Dikgale Mangokoana, Raymond Makola, Winston Nxumalo, Thabe Moses Matsebatlela   +5 more
doaj   +1 more source