Results 1 to 10 of about 24,157 (222)

Synthesis and biological activity of some heterocyclic compounds containing quinoxaline and coumarin moieties [PDF]

Journal of the Serbian Chemical Society, 2000
2,3-Dichloroquinoxaline (2) condensed with 7,8-dihydroxy-4-methylcoumarin to give the 1,4-dioxane derivative 4. 2.3-Dichloroquinoxaline (2) reacted with 4-hydroxycoumarin, 7-hydroxy-4-methylcoumarin and acyl hydrazide 13 to give either the 2,3 ...
M. E. ABD EL-FATTAH, I. M. EL-DEEN
doaj   +2 more sources

Analgesic and anti-inflammatory activity of quinoxaline derivatives: Design synthesis and characterization

Results in Chemistry, 2023
Medicinal chemistry is a basic science that involves identification, synthesis and development of new drugs for therapeutic use. Biological importance of heterocycles makes them more crucial in pharmaceutical industries.In this work heterocyclics like ...
Geethavani Meka, Ramakrishna Chintakunta
doaj   +1 more source

Synthesis, Biological Evaluation, and In Silico Studies of New Acetylcholinesterase Inhibitors Based on Quinoxaline Scaffold

Molecules, 2021
A quinoxaline scaffold exhibits various bioactivities in pharmacotherapeutic interests. In this research, twelve quinoxaline derivatives were synthesized and evaluated as new acetylcholinesterase inhibitors.
Paptawan Suwanhom, Jirakrit Saetang, Pasarat Khongkow, Teerapat Nualnoi, Varomyalin Tipmanee, Luelak Lomlim   +5 more
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Quinoxaline Moiety: A Potential Scaffold against Mycobacterium tuberculosis

Molecules, 2021
Background. The past decades have seen numerous efforts to develop new antitubercular agents. Currently, the available regimens are lengthy, only partially effective, and associated with high rates of adverse events. The challenge is therefore to develop
Marc Montana, Vincent Montero, Omar Khoumeri, Patrice Vanelle   +3 more
doaj   +1 more source

A High-Throughput Screening Method for Determining the Optimized Synthesis Conditions of Quinoxaline Derivatives Using Microdroplet Reaction

Frontiers in Chemistry, 2020
Quinoxaline derivatives demonstrate many distinguished chemical, biological, and physical properties and have a wide application in dyes, electroluminescent material, organic semiconductors, biological agents, etc.
Yanmei Yang, Junmin Liu, Zhenzhen Chen, Weihua Niu, Ran Li, Le Niu, Peng Yang, Xiaoyan Mu, Bo Tang   +8 more
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Density Functional Theory and Quantitative Structure-Activity Relationship Studies of some Quinoxaline derivatives as potential Corrosion Inhibitors for Copper in Acidic Medium

International Journal of Electrochemical Science, 2012
Density Functional Theory (DFT) using the B3LYP functional and Quantitative Structure-Activity Relationship QSAR studies is reported on some quinoxaline derivatives namely 3-methyl-2-phenyl quinoxaline (MPQ), 2,3-diphenyl quinoxaline (PPQ), 3-methyl-2(2 ...
Mwadham M. Kabanda, Eno E. Ebenso
doaj   +1 more source

Neutron scattering from a coordination polymer quantum paramagnet [PDF]

, 2006
Inelastic neutron scattering measurements are reported for a powder sample of the spin-1/2 quantum paramagnet $\rm Cu(Quinoxaline)Br_2$. Magnetic neutron scattering is identified above an energy gap of 1.9 meV.
B. D. Lewis, C. Broholm, C. Knetter, C. P. Landee, D. Reich, G. S. Uhrig, K. P. Schmidt, K. P. Schmidt, M. Kenzelmann, M. M. Turnbull, P. R. Hammar, S. W. Lovesey, T. Hong, Y. Qiu   +13 more
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Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA [PDF]

, 1987
Forms of the DNA double helix containing non-Watson-Crick base-pairing have been discovered recently based on x-ray diffraction analysis of quinoxaline antibiotic-oligonucleotide complexes.
Dervan, Peter B., Mendel, David
core   +2 more sources

Alkoxyallene‐Based LANCA Three‐Component Synthesis of 1,2‐Diketones, Quinoxalines, and Unique Isoindenone Dimers and a Computational Study of the Isoindenone Dimerization [PDF]

, 2020
A series of β‐alkoxy‐β‐ketoenamides was prepared by the well‐established LANCA three‐component reaction of lithiated 1‐(2‐trimethylsilylethoxy)‐substituted allenes, nitriles, and α,β‐unsaturated carboxylic acids.
Bera M. K., Holland J. M., Lechel T., Lechel T., Zimmer R., Zimmer R., Zimmer R.   +6 more
core   +1 more source

Induction of Cell Death in Human A549 Cells Using 3-(Quinoxaline-3-yl) Prop-2-ynyl Methanosulphonate and 3-(Quinoxaline-3-yl) Prop-2-yn-1-ol

Molecules, 2019
Despite major advancements in the development of various chemotherapeutic agents, treatment for lung cancer remains costly, ineffective, toxic to normal non-cancerous cells, and still hampered by a high level of remissions.
Mixo Aunny Sibiya, Lerato Raphoko, Dikgale Mangokoana, Raymond Makola, Winston Nxumalo, Thabe Moses Matsebatlela   +5 more
doaj   +1 more source