Results 1 to 10 of about 6,970 (213)

Protocol for stereodivergent asymmetric hydrogenation of quinoxalines [PDF]

STAR Protocols, 2023
Summary: Chiral 1,2,3,4-tetrahydroquinoxalines are ubiquitous in natural products and bioactive molecules. Herein, we disclose a protocol for stereodivergent asymmetric hydrogenation of disubstituted quinoxalines for the preparation of both cis- and ...
Mingyang Wang, Chenguang Liu, Qiang Liu
doaj   +2 more sources

Benzylic C–H Oxidation: Recent Advances and Applications in Heterocyclic Synthesis [PDF]

Molecules
Benzylic C–H oxidation to form carbonyl compounds, such as ketones, is a fundamental transformation in organic synthesis as it allows for the preparation of versatile intermediates.
Nonhlelo Majola, Vineet Jeena
doaj   +2 more sources

Anticancer, anti-inflammatory and analgesic activities of aminoalcohol-based quinoxaline small molecules [PDF]

Acta Cirúrgica Brasileira
Purpose: Bioactive molecules are relevant to fight cancer and associated conditions. Quinoxaline is a privileged N-heterocycle, notably as anticancer agents.
Jannyely Moreira Neri, Paula Emília Apolônio Siqueira, Ana Luiza Cabral de Sá Leitão Oliveira, Renata Mendonça Araújo, Raimundo Fernandes de Araújo Júnior, Agnes Andrade Martins, Isabelle de Lima Marques, Rafaela Alcindo Silva, Aurigena Antunes de Araújo, Fabrício Gava Menezes   +9 more
doaj   +2 more sources

Synthesis and Structure-Chirality Relationship Analysis of Steroidal Quinoxalines to Design and Develop New Chiral Drugs

Chemistry, 2021
Of the utmost importance of chirality in organic compounds and drugs, the present work reports structure-chirality relationship of three steroidal quinoxalines, which were synthesised by condensing diaminobenzenes with cholestenone.
Rashid Mehmood, Naghmana Rashid, Shakir Ullah, Maria John Newton Amaldoss, Charles Christopher Sorrell   +4 more
doaj   +1 more source

A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines

SynOpen, 2021
A highly efficient and catalyst-free protocol is reported for the synthesis of quinoxalines via the classical cyclocondensation reaction between aryldiamines and dicarbonyl compounds.
Vijayaragavan Elumalai, Jørn H. Hansen
doaj   +1 more source

Sustainable production of value-added N-heterocycles from biomass-derived carbohydrates via spontaneous self-engineering

National Science Open, 2023
: Synthetic N-heterocyclic compounds, such as quinoxalines, have shown a crucial role in pharmaceutical as well as food and dye industries. However, the traditional synthesis toward N-heterocycles relies on multistep energy and cost-intensive non ...
Yu Feng, Liu Chong, Tan Fenghua, Liao Yuhe, Wang Liang, Li Yuping, Xiao Feng-Shou   +6 more
doaj   +1 more source

Green Synthesis of New Pyrrolo [1,2-a] quinoxalines as Antiproliferative Agents in GPER-expressing Breast Cancer Cells

Journal of Chemistry, 2021
4,5-Dihydropyrrolo [1,2-a]quinoxalines are interesting druggable scaffolds, with multifaceted biological properties, including anticancer properties targeting the G protein-coupled estrogen receptor 1 (GPER).
Gabriele Carullo, Sarah Mazzotta, Francesca Giordano, Francesca Aiello   +3 more
doaj   +1 more source

Synthesis of Functionalized 3H-pyrrolo-[1,2,3-de] Quinoxalines via Gold-Catalyzed Intramolecular Hydroamination of Alkynes

Molecules, 2023
A gold-catalyzed protocol to obtain functionalized 3H-pyrrolo [1,2,3-de] quinoxalines from suitable substituted N-alkynyl indoles has been proposed. The mild reaction conditions were revealed to be compatible with different functional groups, including ...
Antonia Iazzetti, Giancarlo Fabrizi, Antonella Goggiamani, Federico Marrone, Alessio Sferrazza, Karim Ullah   +5 more
doaj   +1 more source

Quinoxaline-2-carbonitrile [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
In the title compound, C9H5N3, the quinoxaline ring is essentially planar, with a maximum deviation of 0.012 (1) Å. Short inter­molecular distances between the centroids of the 2,3-dihydro­pyrazine and benzene rings [3.6490 (5) Å] indicate the existence of π⋯π inter­actions.
Hoong‐Kun Fun, Ching Kheng Quah, Annada C. Maity, Nirmal K. Das, Shyamaprosad Goswami   +4 more
openaire   +3 more sources

Bis[2-(thiophen-2-yl)quinoxaline-κN4]silver(I) perchlorate

IUCrData, 2023
The crystal of the title salt, [Ag(C12H8N2S)2]ClO4, has C2/c symmetry whereby the silver(I) atom sits on a twofold rotation axis, as does the perchlorate anion, which is disordered about this axis.
Guy Crundwell
doaj   +1 more source