Results 41 to 50 of about 26,379 (326)
Molecules, 2019 We report the synthesis and relevant pharmacological properties of the quinoxalinetacrine (QT) hybrid QT78 in a project targeted to identify new non-hepatotoxic tacrine derivatives for Alzheimer’s disease therapy.
Eva Ramos +11 more
doaj +1 more source
Nucleic Acids Research, 2019 Conventional chemotherapy remains the primary treatment option for triple-negative breast cancer (TNBC). However, the current chemotherapeutic drugs have limited effects on TNBC, and often lead to serious side effects as well as drug resistance.
Ming-Hao Hu +3 more
semanticscholar +1 more source
Journal of Heterocyclic Chemistry, 1973 AbstractThe treatment of 3β‐hydroxy‐16α‐bromo‐5α‐androstan‐17‐one, 3β‐acetoxy‐16α‐bromo‐5‐androsten‐17‐one and 21‐bromo‐5‐pregnen‐3β‐ol‐20‐one with 4,5‐dimethyl‐o‐phenylenediamine gave substituted quinoxalines.Hydrolysis of 3β‐acetoxy‐5‐androsteno[16,17‐b]‐6′,7′‐dimethylquinoxaline produced the corresponding 3β‐hydroxy compound.
openaire +3 more sources
2-(3-Nitrophenoxy)quinoxaline [PDF]
Acta Crystallographica Section E Structure Reports Online, 2010 In the title mol-ecule, C(14)H(9)N(3)O(3), the dihedral angle between the quinoxaline and benzene rings is 77.13 (9)°. The mol-ecule is twisted about the ether-benzene O-C bond, with a C-O-C-C torsion angle of -102.8 (2)°. In the crystal, mol-ecules are linked by C-H⋯O hydrogen bonds, forming layers in the ab plane, with one nitro O atom accepting two ...
Hassan, N.D. +5 more
openaire +5 more sources
Hydrogen Bond‐Assisted PCET and Formation of WIII─OH in Bis(Dithiolene) Complex
Angewandte Chemie, EarlyView.The single crystal structure of complex [2Et3NH‐1] reveals hydrogen bonding at both W‐oxo and dithiolene‐S sites within the bis(dithiolene) WIV‐oxo complex. This finding provides critical evidence for dithiolene's involvement in proton reactions in high‐valent W‐oxo complexes.
Wonjung Lee +9 more
wiley +2 more sources
Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives
Pharmaceuticals, 2010 2-Chloro-3-methylquinoxaline was selected as a nucleus around which various molecular transformations were performed to obtain new compounds expected to possess optimized antimicrobial activity.
Ram Gopal Singhal +3 more
doaj +1 more source
Sinteza i biološko djelovanje novih 1-benzil i 1-benzoil 3-heterocikličkih derivata indola [PDF]
, 2010 Starting from 1-benzyl- (2a) and 1-benzoyl-3-bromoacetyl indoles (2b) new heterocyclic, 2-thioxoimidazolidine (4a,b), imidazolidine-2,4-dione (5a,b), pyrano(2,3-d)imidazole (8a,b and 9a,b), 2-substituted quinoxaline (11a,b–17a,b) and triazolo(4,3-a ...
A. Barry +23 more
core +2 more sources
Angewandte Chemie, EarlyView.Herein, we report the use of bis(trimethylaluminum)‐1,4‐diazabicyclo[2.2.2]octane (DABAl‐Me3) as practical source of radicals for the introduction of valuable methyl groups to aryl bromides via a Nickel/metallaphotocatalytic cross coupling strategy.
Jonas Djossou +8 more
wiley +2 more sources
Synthesis of new derivants 11h-indeno[1,2-b] - quinoxaline as perspective inhibitors of JNK (C-Jun n-terminalnal kinase) [PDF]
, 2017 Various quinoxalines show biological activity and have such properties as antiviral, antibacterial, antimicrobial, anti-inflammatory, anticancer, antidepressant, vermicidal, and act as inhibitors of kinases [1].
Коврижина, А. Р.
core +2 more sources
Angewandte Chemie, EarlyView.Two solvated hydrogen‐bonded organic frameworks (HOFs) based on tetraazaanthraquinone and anthraquinone were found to undergo quasi single‐crystal‐to‐single‐crystal transformations through hydrogen‐bond cleavage and re‐formation. These transformations induced crystal crack propagations, and molecular‐level correlations between the structural ...
Haruka Kubo +2 more
wiley +2 more sources