Results 41 to 50 of about 14,696 (253)

Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives

Pharmaceuticals, 2010
2-Chloro-3-methylquinoxaline was selected as a nucleus around which various molecular transformations were performed to obtain new compounds expected to possess optimized antimicrobial activity.
Ram Gopal Singhal, Syed Riaz Hashim, Sanjay Kumar Deivedi, Dharmchand Prasad Singh   +3 more
doaj   +1 more source

Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds [PDF]

, 2019
he triple-negative breast cancer (TNBC) is characterized by a more aggressive nature and poorer prognosis, nowadays none pharmaceutical approach is still available.
Erika Cione, Francesca Aiello, Gabriele Carullo, Luisa Amendola, Maria Cristina Caroleo, Mariarita Perri, Sarah Mazzotta   +6 more
core   +4 more sources

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer’s Disease Therapy

Molecules, 2019
We report the synthesis and relevant pharmacological properties of the quinoxalinetacrine (QT) hybrid QT78 in a project targeted to identify new non-hepatotoxic tacrine derivatives for Alzheimer’s disease therapy.
Eva Ramos, Alejandra Palomino-Antolín, Manuela Bartolini, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, Abdelouahid Samadi, Carol V. Cortina, Mourad Chioua, Javier Egea, Alejandro Romero, José Marco-Contelles   +11 more
doaj   +1 more source

Ethyl 1-benzyl-2-(4-methylphenyl)-1h-pyrrolo[2,3-b]quinoxaline-3-carboxylate and ethyl 6,7-dimethyl-1,2- diphenyl-1h-pyrrolo[2,3-b]quinoxaline-3-carboxylate: synthesis and study on nuclear magnetic resonance spectroscopy

Tạp chí Khoa học và Công nghệ
Synthetic pyrrolo[2,3-b]quinoxalines have been confirmed to possess valuable biological activities and pharmacokinetic properties. However, the presence of heavy metal catalysts in synthesizing these heterocycles has restricted the application of those ...
Vo Viet Dai, Bui Bich Loc, Nguyen Tran Nguyen   +2 more
doaj   +1 more source

A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor

Molecules, 2023
An iodine-mediated one-pot synthesis of pyrrolo/indolo [1,2-a]quinoxalines and quinazolin-4-one via utilizing epoxides as alkyl precursors under metal-free conditions has been described.
Xueyan Lv, Lili Lv, Shichen Li, Chengcheng Ding, Bingchuan Yang, Chen Ma   +5 more
doaj   +1 more source

Bay‐functionalized [7]Helicene Bilayer Nanographenes

Advanced Optical Materials, EarlyView.
Bay‐functionalized [7]helical bilayer nanographenes are synthesized via a scalable, modular strategy enabling late‐stage diversification. Tailored methoxy, diketone, and phenazine substitutions precisely tune redox, photophysical, and chiroptical properties, delivering strong electronic circular dichroism and bright circularly polarized luminescence ...
Anmol Thanai, Vikas Sharma, Louis Minion, Hassan Khan, Hadeel Abbas, George F. S. Whitehead, Avantika Hasija, Jessica Wade, Matthew John Fuchter, Ashok Keerthi   +9 more
wiley   +1 more source

Synthesis of a New Series of Nitrogen/Sulfur Heterocycles by Linking Four Rings: Indole; 1,2,4-Triazole; Pyridazine; and Quinoxaline

Molecules, 2020
A new series of nitrogen and sulfur heterocyclic systems were efficiently synthesized by linking the following four rings: indole; 1,2,4-triazole; pyridazine; and quinoxaline hybrids. The strength of the acid that catalyzes the condensation of 4-amino-5-(
Ahmed T. A. Boraei, Ahmed A. M. Sarhan, Sammer Yousuf, Assem Barakat   +3 more
doaj   +1 more source

INVESTIGATION DICARBONYL COMPOUNDS GENERATED FROM THE MAILLARD REACTIONS OF METHIONINE WITH REDUCING SUGARS TO ENFOLD OFF FLAVOR IN GOAT’S MILK [PDF]

, 2016
Population of goat in Indonesia remains low and stagnant (about 1.2 % per year). In the other hand, Indonesia is a tropical country, which is suite for the goat’s growth. One of strong reason is low in goat-based product’s demand since “goaty” flavor
AL-BAARRI, Ahmad Nimatullah, LEGOWO, Anang M   +1 more
core  

Initial Distance‐Dependent Mean Force Drives Synaptic Vesicle Motion Toward Fusion Sites in Stimulated Hippocampal Neurons

Advanced Science, EarlyView.
Synaptic vesicle (SV) motion and exocytosis dynamics in the presynaptic terminals of live neurons are intimately linked to synaptic transmission during neuronal activity. In this work, it is revealed that, during electrical stimulation, SVs located farther from their fusion sites exhibit greater straightness and experience larger mean forces directed ...
Gyunam Park, Ji‐Hyun Kim, Hunki Lee, Chungwon Park, Sidong Chen, Luke Bates, Jaeyoung Sung, Hyokeun Park   +7 more
wiley   +1 more source

Antioxidant Activity and Oxidation Products of 1,2,3,4- Tetrahydroquinoxalines in Peroxyl Radical Scavenging Reactions, Part I [PDF]

, 2005
This paper studies the antioxidant activity of 1,2,3,4-tetrahydroquinolines, 3,4-dihydro-2H-benzo[1,4]thiazines and 1,2,3,4-tetrahydroquinoxalines in the inhibition of the peroxidation of tetralin induced by an azo initiator.
Nishiyama Tomohiro, Oka Ryohei, Sakaguchi Tomoki, Sakata Toshifumi, Takahashi Masamitsu, Tanaka Daisuke   +5 more
core   +1 more source