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THE CHEMISTRY OF QUINUCLIDINE DERIVATIVES

Russian Chemical Reviews, 1960
CONTENTS I. Introduction 38 II. Quinuclidine 38 III.
M V Rubtsov, E E Mikhlina, L N Yakhontov
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The Chemistry of Quinuclidine

Russian Chemical Reviews, 1969
The review deals with the chemical properties and the biological activity of the derivatives of 1-azabicyclo[2,2,2]octane widely known as quinuclidine. The work of the Soviet School of Chemists, founded by M.V.Rubtsov, in the field of quinuclidine derivatives is reviewed in detail.
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ChemInform Abstract: SYNTHESES OF PIPERIDYLAMIDES OF QUINUCLIDINE‐2‐AND QUINUCLIDINE‐3‐CARBOXYLIC ACIDS

Chemischer Informationsdienst, 1978
AbstractDie Chinuclidin‐2‐ (II) und ‐3‐carbonsäureamide (III) wurden durch Kondensation des Säurechlorids (I) bzw. des isomeren 3‐Chlorcarbonyl‐Derivats mit den entsprechenden Aminen erhalten.
S. BINIECKI, B. PROKOPCZYK
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The structure of dimethylbis(quinuclidine)beryllium

Journal of Organometallic Chemistry, 1971
Abstract The structure of (CH3)2Be·2NC7H13 has been determined by single-crystal X-ray diffraction methods. Four monomeric molecules crystallize in a monoclinic unit cell of dimensions a = 11.82±0.02, b = 12.71±0.02, c = 12.00±0.02 A, and β = 113.1°±0.3°. The space group is P21/c.
C.D. Whitt, J.L. Atwood
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Stereocontrolled approach to quinuclidine derivatives

Tetrahedron Letters, 1998
Abstract Asymmetric Michael-type cyclization of chiral enamino ester (S)-7 furnished the quinuclidinone derivative (3R, 4S)-5, with a high degree of stereoselectivity.
Alexandre J. Da Silva Goes   +2 more
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Study of the tautomerism of 2-ethoxycareonyl-3-oxo derivatives of quinuclidine and benzo[b]quinuclidine

Chemistry of Heterocyclic Compounds, 1972
The tautomerism of 2-ethoxycarbonyl-3-oxoquinuclidine and 2-ethoxycarbonyl-3-oxobenzo-[b]quinuclidine was investigated by means of IR and UV spectra and potentiometric titration. It was found that tautomeric equilibrium between the ketone, enol, and internally ionized forms is realized for 2-ethoxycarbonyl-3-oxoquinuclidine, and the position of the ...
Yu. N. Sheinker   +6 more
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Mass spectra of the substituted quinuclidines

Organic Mass Spectrometry, 1970
AbstractThe mass spectra of the quinuclidine‐2 (and ‐3)‐ones and other functional derivatives of quinuclidine as well as 2‐azaquinuclidine and benzoquinuclidine have been investigated. The fragmentation through the open form of the molecular ion and the applicability of Bredt's rule to amine fragmentation of the bridgehead nitrogen bicyclic systems are
R. G. Kostyanovsky   +3 more
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Novel heterocyclic derivatives of quinuclidine

Journal of Heterocyclic Chemistry, 1967
AbstractTreatment of ethyl 3‐quinuclidinone‐2‐carboxyIate (III) with appropriate reagents gave 2,3‐fused heterocycles including pyrazolol, aminopyrimidinone, and aminopyridazinone types. The thiourea derivative of III could not be cyclized. Triazoline, pyrazoline, and isoxazoline derivatives were prepared by 1,3‐dipolar cycloadditions to the 2‐ and 3 ...
William A. Renters   +2 more
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New derivatives of quinuclidine as potential antihypertensive agents

Journal of Pharmaceutical Sciences, 1967
Five new 3-aminoalkoxy derivatives of quinuclidine have been synthesized. All compounds reduced blood pressure in dogs to varying degrees, the most effective being 3-(3-dimethylaminopropoxy) quinuclidine. The evidence points to ganglionic blockade as the principal mechanism of action with the possibility that it may also be due to some direct ...
L L, Collins, C A, Papacostas, S, Elkin
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Syntheses and Structures of Quinuclidine-Stabilized Amido- and Azidogallanes

Inorganic Chemistry, 2000
Quinuclidine-stabilized amido- and azidogallanes, HGa[N(TMS)2]2(quin) (1), H2Ga[N(TMS)2](quin) (2), HGa-[N(H)(2,6-iPr2C6H3)]2(quin) (3), and H2GaN3(quin) (4), were synthesized from the quinuclidine adducts of mono- and dichlorogallane. Structural determinations revealed that all compounds were monomeric with four-coordinate gallium centers.
B, Luo, V G, Young, W L, Gladfelter
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