Results 131 to 140 of about 1,080 (176)

Quinuclidin-2-ene - based muscarinic antagonists

Life Sciences, 1995
A series of achiral 3-heteroaryl substituted quinuclidin-2-ene derivatives and related compounds have been synthesized by facile methods. The compounds were evaluated for muscarinic and antimuscarinic properties in receptor binding studies using (-)-[3H]-QNB as the radioligand and in a functional assay using isolated guinea pig urinary bladder.
U, Hacksell, B M, Nilsson, G, Nordvall, G, Johansson, S, Sundquist, L, Nilvebrant   +5 more
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Quinuclidine Chemistry: Autocondensation Reactions of 3-Quinuclidinone

Journal of Pharmaceutical Sciences, 1977
During the synthesis of 3-hydroxy-3-ethinylquinuclidine (I), two additional products were isolated and identified as (E)-3-[2-(3-oxoquinuclidine)]quinuclidylidene (III) and (E)-3-[2-(3-hydroxy-3-ethinylquinuclidine)]quinuclidylidene (V). The base-catalyzed autocondensation of 3-quinuclidinone resulted in the alpha,beta-unsaturated ketone dimer (III) as
R A, Sandmann, W C, McHugh
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Molecular aggregates of quinuclidine and chlorophyll a

SPIE Proceedings, 1991
A slightly polar molecule quinuclidine seems to form weakly bound aggregates in concentrated water solutions. Molecular dynamics simulation of a 6 mol water solution indicates clustering of quinuclidine molecules into an almost spherical structure with polar ends of the molecules pointing towards the solvent.
Jouko E. Korppi-Tommola, Aulis Hakkarainen, Vesa M. Helenius   +2 more
openaire   +1 more source

A Diastereoselective Radical Cyclization Approach to Substituted Quinuclidines

The Journal of Organic Chemistry, 2006
A new, concise, and flexible approach to novel quinuclidines has been developed, which employs a phosphorus hydride mediated radical addition/cyclization reaction in the key step. 1,7-Diene 5 reacts with diethyl thiophosphite in an efficient and diastereoselective radical addition/cyclization reaction to give trisubstituted piperidines 4ab. Piperidines
Thomas A, Hunt, Andrew F, Parsons, Robert, Pratt   +2 more
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Reactions of quinuclidine N-oxide and other amine oxides with sulfur dioxide. Structure of quinuclidine sulfur trioxide

The Journal of Organic Chemistry, 1979
Passage of SO/sub 2/ gas through solutions of quinuclidine N-oxide in water or undried organic solvents at ambient temperature resulted in precipitation of sparingly soluble colorless platelets of quinuclidine sulfur trioxide in 85 to 90% yields.
G. J. Kubas, A. C. Larson, R. R. Ryan
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Quinuclidine analogs of tobacco alkaloids

Journal of Medicinal Chemistry, 1971
F D, Reed, A, Burger
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Quinuclidin-4-yl

Journal of the American Chemical Society, 1979
Shelton Bank, William K. S. Cleveland, D. Griller, K. U. Ingold   +3 more
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Quinuclidine∑boranes as Intermediates in Formation and Isolation of Functionalized Quinuclidine Systems

HETEROCYCLES, 1987
Philip L. Stotter, Martin D. Friedman, Gordon O. Dorsey, Robert W. Shiely, Robert F. Williams, David E. Minter   +5 more
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A simple synthesis of quinuclidine

Collection of Czechoslovak Chemical Communications, 1951
R. Lukeš, M. Ferles
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SYNTHESIS OF UGI COMPOUNDS WITH QUINUCLIDINE

Book of Abstracts 9th Faculty of Science PhD Student Symposium
Bioactive chemical compounds such as quinuclidine derivatives are recognized as unities with a broad spectrum of biological activities also in the fields of neurodegenerative diseases. Thus, they are used in therapy for myasthenia gravis, Alzheimer and Parkinson’s disease, some infectious diseases and as antidotes for poisoning with various ...
Primožič, Ines, Ramić, Alma, Laučan, Matea   +2 more
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