Results 31 to 40 of about 4,431 (185)

A Rhodococcal Transcriptional Regulatory Mechanism Detects the Common Lactone Ring of AHL Quorum-Sensing Signals and Triggers the Quorum-Quenching Response

Frontiers in Microbiology, 2018
The biocontrol agent Rhodococcus erythropolis disrupts virulence of plant and human Gram-negative pathogens by catabolizing their N-acyl-homoserine lactones.
Corinne Barbey, Corinne Barbey, Corinne Barbey, Corinne Barbey, Andrea Chane, Andrea Chane, Jean-François Burini, Jean-François Burini, Olivier Maillot, Olivier Maillot, Annabelle Merieau, Annabelle Merieau, Mathias Gallique, Mathias Gallique, Amélie Beury-Cirou, Amélie Beury-Cirou, Amélie Beury-Cirou, Yoan Konto-Ghiorghi, Yoan Konto-Ghiorghi, Marc Feuilloley, Marc Feuilloley, Virginie Gobert, Virginie Gobert, Virginie Gobert, Xavier Latour, Xavier Latour   +25 more
doaj   +1 more source

Engineering quorum quenching enzymes: progress and perspectives [PDF]

Biochemical Society Transactions, 2019
Abstract Quorum sensing is a key contributor to the virulence of many important plant, animal and human pathogens. The disruption of this signalling—a process referred to as ‘quorum quenching’—is a promising new approach for controlling microbial pathogens.
Shereen A. Murugayah, Monica L. Gerth
openaire   +2 more sources

Quorum quenching quandary: resistance to antivirulence compounds [PDF]

The ISME Journal, 2011
Abstract Quorum sensing (QS) is the regulation of gene expression in response to the concentration of small signal molecules, and its inactivation has been suggested to have great potential to attenuate microbial virulence. It is assumed that unlike antimicrobials, inhibition of QS should cause less Darwinian selection pressure for ...
Toshinari, Maeda, García-Contreras, Rodolfo, Mingming, Pu, Sheng, Lili, García, Luis Rene, Tomás, María, Wood, Thomas K.   +6 more
openaire   +3 more sources

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

Angewandte Chemie, EarlyView.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog, Keishi Ishida, Evelyn M. Molloy, Ron Hermenau, Kirstin Scherlach, Christian Hertweck   +5 more
wiley   +2 more sources

Screening of N-Acyl Homoserine Lactone-degrading Bacteria and Evaluation of Their Quorum Quenching Activities

Shipin gongye ke-ji
To study the types of quorum quenching bacteria in soil and their quorum quenching characteristics, the study screened, isolated, and identified quorum quenching strains from soil and assessed their quorum quenching properties, the inhibitory and ...
Xiqian TAN, Xiaoqing WANG, Fangchao CUI, Dangfeng WANG, Xinran LÜ, Xuepeng LI, Jianrong LI   +6 more
doaj   +1 more source

Signal Disruption Leads to Changes in Bacterial Community Population

Frontiers in Microbiology, 2019
The disruption of bacterial signaling (quorum quenching) has been proven to be an innovative approach to influence the behavior of bacteria. In particular, lactonase enzymes that are capable of hydrolyzing the N-acyl homoserine lactone (AHL) molecules ...
Michael Schwab, Michael Schwab, Celine Bergonzi, Celine Bergonzi, Jonathan Sakkos, Christopher Staley, Christopher Staley, Qian Zhang, Qian Zhang, Michael J. Sadowsky, Michael J. Sadowsky, Michael J. Sadowsky, Alptekin Aksan, Alptekin Aksan, Mikael Elias, Mikael Elias   +15 more
doaj   +1 more source

Breaking down bacterial communication: a review of quorum quenching agents

Future Journal of Pharmaceutical Sciences, 2023
Background Bacterial cells communicate via small extracellular molecules that facilitate gene expression which is dependent on cell density and this mechanism is known as Quorum Sensing (QS).
Tresa Boban, Sahaya Nadar, Savita Tauro
doaj   +1 more source

Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching

Angewandte Chemie, EarlyView.
Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Bengt H. Gless, Riccardo Milazzo, Martin S. Bojer, Benjamin S. Sereika‐Bejder, Hanne Ingmer, Christian A. Olsen   +5 more
wiley   +2 more sources

Rhodotorula Mucilaginosa, a Quorum Quenching Yeast Exhibiting Lactonase Activity Isolated from a Tropical Shoreline

Sensors, 2014
Two microbial isolates from a Malaysian shoreline were found to be capable of degrading N-acylhomoserine lactones. Both Matrix Assisted Laser Desorption Ionization-Time of Flight-Mass Spectrometry and 18S rDNA phylogenetic analyses confirmed that these ...
Norshazliza Ab Ghani, Joanita Sulaiman, Zahidah Ismail, Xin-Yue Chan, Wai-Fong Yin, Kok-Gan Chan   +5 more
doaj   +1 more source

Quorum quenching: role in nature and applied developments [PDF]

FEMS Microbiology Reviews, 2015
Quorum sensing (QS) refers to the capacity of bacteria to monitor their population density and regulate gene expression accordingly: the QS-regulated processes deal with multicellular behaviors (e.g. growth and development of biofilm), horizontal gene transfer and host-microbe (symbiosis and pathogenesis) and microbe-microbe interactions.
Grandclément, Catherine, Tannières, Mélanie, Moréra, Solange, Dessaux, Yves, Faure, Denis   +4 more
openaire   +3 more sources