Results 51 to 60 of about 352,159 (203)

Crystal Structures of a Quorum-quenching Antibody [PDF]

Journal of Molecular Biology, 2007
A large number of Gram-negative bacteria employ N-acyl homoserine lactones (AHLs) as signaling molecules in quorum sensing, which is a population density-dependent mechanism to coordinate gene expression. Antibody RS2-1G9 was elicited against a lactam mimetic of the N-acyl homoserine lactone and represents the only reported monoclonal antibody that ...
Erik W, Debler, Gunnar F, Kaufmann, Robert N, Kirchdoerfer, Jenny M, Mee, Kim D, Janda, Ian A, Wilson   +5 more
openaire   +2 more sources

A Rhodococcal Transcriptional Regulatory Mechanism Detects the Common Lactone Ring of AHL Quorum-Sensing Signals and Triggers the Quorum-Quenching Response

Frontiers in Microbiology, 2018
The biocontrol agent Rhodococcus erythropolis disrupts virulence of plant and human Gram-negative pathogens by catabolizing their N-acyl-homoserine lactones.
Corinne Barbey, Corinne Barbey, Corinne Barbey, Corinne Barbey, Andrea Chane, Andrea Chane, Jean-François Burini, Jean-François Burini, Olivier Maillot, Olivier Maillot, Annabelle Merieau, Annabelle Merieau, Mathias Gallique, Mathias Gallique, Amélie Beury-Cirou, Amélie Beury-Cirou, Amélie Beury-Cirou, Yoan Konto-Ghiorghi, Yoan Konto-Ghiorghi, Marc Feuilloley, Marc Feuilloley, Virginie Gobert, Virginie Gobert, Virginie Gobert, Xavier Latour, Xavier Latour   +25 more
doaj   +1 more source

Quorum quenching quandary: resistance to antivirulence compounds [PDF]

The ISME Journal, 2011
Abstract Quorum sensing (QS) is the regulation of gene expression in response to the concentration of small signal molecules, and its inactivation has been suggested to have great potential to attenuate microbial virulence. It is assumed that unlike antimicrobials, inhibition of QS should cause less Darwinian selection pressure for ...
Toshinari, Maeda, Rodolfo, García-Contreras, Mingming, Pu, Lili, Sheng, Luis Rene, Garcia, Maria, Tomás, Thomas K, Wood   +6 more
openaire   +2 more sources

Screening of N-Acyl Homoserine Lactone-degrading Bacteria and Evaluation of Their Quorum Quenching Activities

Shipin gongye ke-ji
To study the types of quorum quenching bacteria in soil and their quorum quenching characteristics, the study screened, isolated, and identified quorum quenching strains from soil and assessed their quorum quenching properties, the inhibitory and ...
Xiqian TAN, Xiaoqing WANG, Fangchao CUI, Dangfeng WANG, Xinran LÜ, Xuepeng LI, Jianrong LI   +6 more
doaj   +1 more source

Signal Disruption Leads to Changes in Bacterial Community Population

Frontiers in Microbiology, 2019
The disruption of bacterial signaling (quorum quenching) has been proven to be an innovative approach to influence the behavior of bacteria. In particular, lactonase enzymes that are capable of hydrolyzing the N-acyl homoserine lactone (AHL) molecules ...
Michael Schwab, Michael Schwab, Celine Bergonzi, Celine Bergonzi, Jonathan Sakkos, Christopher Staley, Christopher Staley, Qian Zhang, Qian Zhang, Michael J. Sadowsky, Michael J. Sadowsky, Michael J. Sadowsky, Alptekin Aksan, Alptekin Aksan, Mikael Elias, Mikael Elias   +15 more
doaj   +1 more source

Quorum Quenching in Culturable Phyllosphere Bacteria from Tobacco [PDF]

International Journal of Molecular Sciences, 2013
Many Gram-negative plant pathogenic bacteria employ a N-acylhomoserine lactone (AHL)-based quorum sensing (QS) system to regulate their virulence traits. A sustainable biocontrol strategy has been developed using quorum quenching (QQ) bacteria to interfere with QS and protect plants from pathogens. Here, the prevalence and the diversity of QQ strains
Ma, Anzhou, Lv, Di, Zhuang, Xuliang, Zhuang, Guoqiang   +3 more
openaire   +2 more sources

Rhodotorula Mucilaginosa, a Quorum Quenching Yeast Exhibiting Lactonase Activity Isolated from a Tropical Shoreline

Sensors, 2014
Two microbial isolates from a Malaysian shoreline were found to be capable of degrading N-acylhomoserine lactones. Both Matrix Assisted Laser Desorption Ionization-Time of Flight-Mass Spectrometry and 18S rDNA phylogenetic analyses confirmed that these ...
Norshazliza Ab Ghani, Joanita Sulaiman, Zahidah Ismail, Xin-Yue Chan, Wai-Fong Yin, Kok-Gan Chan   +5 more
doaj   +1 more source

Quorum Quenching: A Drug Discovery Approach Against Pseudomonas aeruginosa.

Microbiology Research, 2022
Pseudomonas aeruginosa, a ubiquitous opportunistic and nosocomial biofilm-forming pathogen with complex, interconnected and hierarchical nature of QS systems (Las, Rhl, PQS, and IQS), is posing the biggest challenge to the healthcare sector and have made
M. Rather, Debanjan Saha, Shuvam Bhuyan, A. Jha, M. Mandal   +4 more
semanticscholar   +1 more source

An Integrated Quorum Quenching Biocatalytic Nanoplatform for Synergistic Chemo-Photothermal Eradication of P. aeruginosa Biofilm Infections.

Acta Biomaterialia, 2023
Decontamination of biofilm-associated infections presents a significant challenge due to the physical and chemical barrier created by the formation of extracellular matrices.
Yue Song, Rui Wang, Yu-Zhu Pan, Dan Fang, Yuan Tian, Shaobing Zhou   +5 more
semanticscholar   +1 more source

Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria

Microorganisms, 2020
Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome and is related to cell density. The high-density colony population can generate a sufficient number of small molecule signals, activate a variety of downstream ...
Xihong Zhao, Zixuan Yu, Tian Ding
doaj   +1 more source