Results 31 to 40 of about 49,102 (252)

α-Glucosidase-driven metabolism as a potential therapeutic vulnerability in Candida albicans

Frontiers in Microbiology
Candida albicans remains a leading etiological agent of both mucosal and invasive fungal infections. The increasing prevalence of antifungal resistance and limited therapeutic options pose a significant clinical challenge and highlight the need for novel
Joyati Mitra, Anusree Sajeevan, Swathi Sujith, Sasvin Paramasivam, Karthi Shanmugam, Karthi Shanmugam, Adline Princy Solomon   +6 more
doaj   +1 more source

Transcriptome analysis of acyl-homoserine lactone-based quorum sensing regulation in Yersinia pestis [corrected]. [PDF]

PLoS ONE, 2013
The etiologic agent of bubonic plague, Yersinia pestis, senses self-produced, secreted chemical signals in a process named quorum sensing. Though the closely related enteric pathogen Y.
Christopher N LaRock, Jing Yu, Alexander R Horswill, Matthew R Parsek, F Chris Minion   +4 more
doaj   +1 more source

Effect of Autoinducer-2 Quorum Sensing Inhibitor on Interspecies Quorum Sensing

Frontiers in Microbiology, 2022
Bacterial drug resistance caused by overuse and misuse of antibiotics is common, especially in clinical multispecies infections. It is of great significance to discover novel agents to treat clinical bacterial infections. Studies have demonstrated that autoinducer-2 (AI-2), a signal molecule in quorum sensing (QS), plays an important role in ...
Kai Jiang, Kai Jiang, Yijie Xu, Yijie Xu, Bo Yuan, Bo Yuan, Bo Yuan, Yuandong Yue, Meihua Zhao, Rui Luo, Hao Wu, Lei Wang, Yuanyuan Zhang, Junhai Xiao, Junhai Xiao, Feng Lin, Feng Lin   +16 more
openaire   +3 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Quorum sensing control of Type VI secretion factors restricts the proliferation of quorum-sensing mutants

eLife, 2016
Burkholderia thailandensis uses acyl-homoserine lactone-mediated quorum sensing systems to regulate hundreds of genes. Here we show that cell-cell contact-dependent type VI secretion (T6S) toxin-immunity systems are among those activated by quorum ...
Charlotte Majerczyk, Emily Schneider, E Peter Greenberg   +2 more
doaj   +1 more source

Si‐Doped Nanocrystalline Diamond as Highly Sensitive Luminescence Thermometer for the Physiological Temperature Range

Advanced Functional Materials, EarlyView.
In this work, diamonds with negative charged silicon‐vacancy (SiV−) centers have been designed for use as thermometers in biomedical applications. Multiparametric analysis of the emission characteristics of the SiV− centers provides extraordinary sensitivity for temperature detection in the physiological temperature range.
María Gragera, Iván Carrillo‐Berdugo, Josue Millán, Paulius Pobedinskas, Antonio Freire, Ken Haenen, Javier Navas   +6 more
wiley   +1 more source

Quorum sensing intervened bacterial signaling: Pursuit of its cognizance and repression

Journal of Genetic Engineering and Biotechnology, 2018
Bacteria communicate within a system by means of a density dependent mechanism known as quorum sensing which regulate the metabolic and behavioral activities of a bacterial community.
Kayeen Vadakkan, Abbas Alam Choudhury, Ramya Gunasekaran, Janarthanam Hemapriya, Selvaraj Vijayanand   +4 more
doaj   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source