Results 41 to 50 of about 103,808 (290)

Microfluidic study of the chemotactic response of Escherichia coli to amino acids, signaling molecules and secondary metabolites [PDF]

, 2015
Quorum sensing and chemotaxis both affect bacterial behavior on the population level. Chemotaxis shapes the spatial distribution of cells, while quorum sensing realizes a cell-density dependent gene regulation.
Galajda, Péter, Gombai, É., Hodula, O., Kerényi, Ádám, Nagy, Krisztina, Ormos, Pál, Sipos, Orsolya, Valkai, Sándor   +7 more
core   +1 more source

α-Glucosidase-driven metabolism as a potential therapeutic vulnerability in Candida albicans

Frontiers in Microbiology
Candida albicans remains a leading etiological agent of both mucosal and invasive fungal infections. The increasing prevalence of antifungal resistance and limited therapeutic options pose a significant clinical challenge and highlight the need for novel
Joyati Mitra, Anusree Sajeevan, Swathi Sujith, Sasvin Paramasivam, Karthi Shanmugam, Karthi Shanmugam, Adline Princy Solomon   +6 more
doaj   +1 more source

Quorum sensing intervened bacterial signaling: Pursuit of its cognizance and repression

Journal of Genetic Engineering and Biotechnology, 2018
Bacteria communicate within a system by means of a density dependent mechanism known as quorum sensing which regulate the metabolic and behavioral activities of a bacterial community.
Kayeen Vadakkan, Abbas Alam Choudhury, Ramya Gunasekaran, Janarthanam Hemapriya, Selvaraj Vijayanand   +4 more
doaj   +1 more source

Active Learning‐Accelerated Discovery of Fibrous Hydrogels with Tissue‐Mimetic Viscoelasticity

Advanced Functional Materials, EarlyView.
Active learning accelerates the design of fibrous hydrogels that mimic the viscoelasticity of native tissues. By integrating multi‐objective optimization and closed‐loop experimentation, this approach efficiently identifies optimal formulations from thousands of possibilities and decouples elasticity and viscosity. The resulting hydrogels offer tunable
Zhengkun Chen, Zheyuan Miao, Gary Tom, Austin H. Cheng, Elizaveta Gusarova, Benjamen Zondag, Tianyi Wu, Dianoosh Kalhori, Boris Hinz, Milad Abolhasani, Alán Aspuru‐Guzik, Eugenia Kumacheva   +11 more
wiley   +1 more source

Quorum sensing control of Type VI secretion factors restricts the proliferation of quorum-sensing mutants

eLife, 2016
Burkholderia thailandensis uses acyl-homoserine lactone-mediated quorum sensing systems to regulate hundreds of genes. Here we show that cell-cell contact-dependent type VI secretion (T6S) toxin-immunity systems are among those activated by quorum ...
Charlotte Majerczyk, Emily Schneider, E Peter Greenberg   +2 more
doaj   +1 more source

Spatial Dispersal of Bacterial Colonies Induces a Dynamical Transition From Local to Global Quorum Sensing

, 2016
Bacteria communicate using external chemical signals called autoinducers (AI) in a process known as quorum sensing (QS). QS efficiency is reduced by both limitations of AI diffusion and potential interference from neighboring strains.
Boedicker, James Q., Yusufaly, Tahir I.
core   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Quorum sensing in African trypanosomes [PDF]

Current Opinion in Microbiology, 2019
Many microbial eukaryotes exhibit cell-cell communication to co-ordinate group behaviours as a strategy to exploit a changed environment, adapt to adverse conditions or regulate developmental responses. Although best characterised in bacteria, eukaryotic microbes have also been revealed to cooperate to optimise their survival or dissemination.
Rojas Martinez, Federico, Matthews, Keith R.   +1 more
openaire   +2 more sources

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Negative regulation of violacein biosynthesis in Chromobacterium violaceum [PDF]

, 2017
In Chromobacteium violaceum, the purple pigment violacein is under positive regulation by the N-acylhomoserine lactone CviI/R quorum sensing system and negative regulation by an uncharacterized putative repressor.
Aguilar, Ahmadian, Alexeyev, Antônio, August, Better, Brazilian National Genome Project, Chandler, Chen, Chernin, De Kievit, Durán, Figurski, Fuqua, Fuqua, Fuqua, Kovach, Ledgham, Lichstein, Loh, Longo, Mattiuzzo, McClean, Michalska, Miller, Mireille Ayé, Morohoshi, O'Toole, Passos da Silva, Rampioni, Rampioni, Rampioni, Rampioni, Sambrook, Schuster, Simon, Spaink, Stachel, Staskawicz, Stauff, Steindler, Swem, Swift, Sánchez, Venturi, Von Bodman, Waters, Winson   +47 more
core   +2 more sources