Results 11 to 20 of about 13,305 (277)

Small Molecule Inhibitors of Bacterial Quorum Sensing

Medical Sciences Forum, 2022
Quorum sensing is a bacterial mechanism that is essential in the pathogenesis of many infections, such as P. aeruginosa. These infections are strongly influenced by specific quorum sensing molecules, such as Autoinducer-2 (AI-2).
Timothy P. O’Sullivan
doaj   +2 more sources

Quorum Sensing and Quorum Quenching with a Focus on Cariogenic and Periodontopathic Oral Biofilms

Microorganisms, 2022
Numerous in vitro studies highlight the role of quorum sensing in the pathogenicity and virulence of biofilms. This narrative review discusses general principles in quorum sensing, including Gram-positive and Gram-negative models and the influence of ...
Patricia P. Wright, Srinivas Sulugodu Ramachandra   +1 more
doaj   +2 more sources

Quorum Sensing of Periodontal Pathogens

Acta Stomatologica Croatica, 2015
The term ‘quorum sensing’ describes intercellular bacterial communication which regulates bacterial gene expression according to population cell density. Bacteria produce and secrete small molecules, named autoinducers, into the intercellular space.
Darije Plančak, Larisa Musić, Ivan Puhar   +2 more
doaj   +2 more sources

Research progress on the mechanisms by which plant-originated quorum sensing inhibitors inhibit pathogenic bacteria of acne

Pifu-xingbing zhenliaoxue zazhi
The main acne-causing bacteria are Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis. Quorum sensing, an important factor for bacterial survival, is closely associated with expression of bacterial virulence factors and biofilm
Liqi LUO, Liuqi ZHENG, Jingyi LU, Hai ZHANG, Li BAI   +4 more
doaj   +2 more sources

Synergy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Inhibiting P.aeruginosa Quorum Sensing [PDF]

, 2017
ABSTRACT The threat of antibiotic resistant bacteria has called for alternative antimicrobial strategies that would mitigate the increase of classical resistance mechanism. Many bacteria employ quorum sensing (QS) to govern the production of virulence genes and formation of drug-resistance biofilms.
Fong, July, Zhang, Chaodong, Yang, Renliang, Boo, Zhao Zhi, Tan, Soon Keat, Nielsen, Thomas E., Givskov, Michael, Wu, Bin, Su, Haibin, Yang, Liang   +9 more
openaire   +2 more sources

Quorum sensing and its inhibition mechanisms [PDF]

BIO Web of Conferences
The article is a brief literature review. This article provides an overview of the Quorum Sensing system in bacterial communities, highlighting the peculiarities of the system for gram-positive and gramnegative microorganisms. Basic information about the
Prazdnova Evgeniya, Bren Anzhelica, Golovko Lilia, Teperin Alexander, Xu Delin, Zhao Xinqing, Chikindas Michael, Rudoy Dmitry   +7 more
doaj   +3 more sources

Quorum-sensing inhibitors as anti-pathogenic drugs

International Journal of Medical Microbiology, 2006
Quorum-sensing (QS) signalling systems of pathogens are central regulators for the expression of virulence factors and represent highly attractive targets for the development of novel therapeutics. In Pseudomonas aeruginosa, QS systems are also involved in elevated antibiotic tolerance of biofilms as well as elevated tolerance to the activity of the ...
Thomas B Rasmussen, Michael Givskov
exaly   +3 more sources

Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa. [PDF]

Front Cell Infect Microbiol, 2018
Pseudomonas aeruginosa is known as an opportunistic pathogen that often causes persistent infections associated with high level of antibiotic-resistance and biofilms formation. Chemical interference with bacterial cell-to-cell communication, termed quorum sensing (QS), has been recognized as an attractive approach to control infections and address the ...
Fong J, Mortensen KT, Nørskov A, Qvortrup K, Yang L, Tan CH, Nielsen TE, Givskov M.   +7 more
europepmc   +9 more sources

Sumac (Rhus coriaria L) as Quorum Sensing Inhibitors in Staphylococcus aureus

Journal of Pure and Applied Microbiology, 2019
Different solvents were used for sumac extractions to find different active compounds in each fraction, and these fractions were tested on Staphylococcus aureus (which isolated from soft white cheese), the (MIC) minimum inhibitory concentration of each ...
Abdulilah Saleh Ismaeil, Fraidoon A. Saleh   +1 more
doaj   +2 more sources

High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway

Scientific Reports, 2017
The main components of the quorum-sensing system are expected to be favorable targets for drug development to combat various chronic infectious diseases.
Seiji Ishii, Kenji Fukui, Satoshi Yokoshima, Kazuo Kumagai, Youko Beniyama, Tetsuya Kodama, Tohru Fukuyama, Takayoshi Okabe, Tetsuo Nagano, Hirotatsu Kojima, Takato Yano   +10 more
doaj   +2 more sources