The Molecular Architecture of Pseudomonas aeruginosa Quorum-Sensing Inhibitors [PDF]
Marine Drugs, 2022 The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic activity is one of the important inducements for bacteria to develop drug resistance.
Qiaoqiang Li +3 more
doaj +4 more sources
Design of Nanosystems for the Delivery of Quorum Sensing Inhibitors: A Preliminary Study [PDF]
Molecules, 2020 Biofilm production is regulated by the Quorum Sensing system. Nowadays, Quorum Sensing represents an appealing target to design new compounds to increase antibiotics effects and avoid development of antibiotics multiresistance.
Supandeep Singh Hallan +8 more
doaj +7 more sources
Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives [PDF]
Marine Drugs, 2019 Quorum sensing inhibitors (QSIs) present a promising alternative or potent adjuvants of conventional antibiotics for the treatment of antibiotic-resistant bacterial strains, since they could disrupt bacterial pathogenicity without imposing selective ...
Jianwei Chen +7 more
doaj +4 more sources
Research Progress on Quorum Sensing and Quorum Sensing Inhibitors of Aeromonas [PDF]
Shipin Kexue, 2023 Bacterial quorum sensing (QS) is a process in which bacteria conduct chemical communication through the production, release, accumulation and induction of signaling molecules called autoinducers (AI).
TU Mingxia, LIU Lei, GAO Liang, ZHANG Ying, GUI Meng, RAO Yu
doaj +2 more sources
Design, synthesis, and biological evaluation of benzoheterocyclic sulfoxide derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Six series of benzoheterocyclic sulfoxide derivatives were designed and synthesised as Pseudomonas aeruginosa (P. aeruginosa) quorum sensing inhibitors in this paper.
Shen Mao +5 more
doaj +2 more sources
Interactions among quorum sensing inhibitors. [PDF]
PLoS ONE, 2013 Many pathogenic bacteria use quorum sensing (QS) systems to regulate the expression of virulence genes in a density-dependent manner. In one widespread QS paradigm the enzyme LuxI generates a small diffusible molecule of the acyl-homoserine lactone (AHL)
Rajat Anand, Navneet Rai, Mukund Thattai
doaj +5 more sources
Exploration of CviR-mediated quorum sensing inhibitors from Cladosporium spp. against Chromobacterium violaceum through computational studies [PDF]
Scientific Reports, 2023 An opportunistic human pathogenic bacterium, Chromobacterium violaceum resists the potency of most antibiotics by exploiting the quorum sensing system within their community to control virulence factor expression.
Mahadevamurthy Murali +9 more
doaj +2 more sources
Secondary Metabolites of Actinomycetales as Potent Quorum Sensing Inhibitors Targeting Gram-Positive Pathogens: In Vitro and In Silico Study [PDF]
Metabolites, 2022 Anti-virulence agents are non-bacteriostatic and non-bactericidal emerging therapeutic options which hamper the production of virulence factors in pathogenic flora.
Said E. Desouky +9 more
doaj +2 more sources
Fungal Quorum-Sensing Molecules and Inhibitors with Potential Antifungal Activity: A Review
Molecules, 2019 The theory of persisting independent and isolated regarding microorganisms is no longer accepted. To survive and reproduce they have developed several communication platforms within the cells which facilitates them to adapt the surrounding environmental ...
Arshad Mehmood +5 more
doaj +3 more sources
Quorum Sensing Inhibitors to Quench P. aeruginosa Pathogenicity. [PDF]
Pharmaceuticals (Basel), 2021 The emergence and the dissemination of multidrug-resistant bacteria constitute a major public health issue. Among incriminated Gram-negative bacteria, Pseudomonas aeruginosa has been designated by the WHO as a critical priority threat. During the infection process, this pathogen secretes various virulence factors in order to adhere and colonize host ...
Duplantier M, Lohou E, Sonnet P.
europepmc +5 more sources