Results 41 to 50 of about 13,305 (277)

Design, Synthesis, and Evaluation of Transition-State Analogs as Inhibitors of the Bacterial Quorum Sensing Autoinducer Synthase CepI

, 2020
Quorum sensing is a bacterial signaling system that involves the synthesis and detection of small signal molecules called autoinducers. A main class of autoinducers in Gram-negative bacteria are acylated homoserine lactones, produced by the LuxI family ...
Alec, Esposito, Julia, Stockwell, Nora R., Vail, Sterling, Payne, Scott, Ulrich, Julian, Kellner-Rogers, Erin, Higgins, Alexandra, Estanislau   +7 more
core   +1 more source

Quorum Sensing Interfering Strategies and Their Implications in the Management of Biofilm-Associated Bacterial Infections [PDF]

Brazilian Archives of Biology and Technology, 2020
The bacterial species employ various types of molecular communication systems recognized as quorum sensing for the synchronization of differential gene expression to regulate virulence traits and biofilm formation. A variety of quorum sensing inhibitors;
Samman Munir, Asad Ali Shah, Muhammad Shahid, Irfan Manzoor, Bilal Aslam, Muhammad Hidayat Rasool, Muhammad Saeed, Sultan Ayaz, Mohsin Khurshid   +8 more
doaj   +1 more source

Chloroquine fumardiamides as novel quorum sensing inhibitors

Bioorganic & Medicinal Chemistry Letters, 2020
Quorum sensing inhibitors (QSIs) that specifically interfere with bacterial cell-to-cell communication are considered as an alternative approach to conventional antibacterial therapy. In our study, a set of twenty-six fumardiamides with a quinoline head-group were evaluated as potential QSIs.
Maja Beus, Kirsi Savijoki, Jayendra Z. Patel, Jari Yli-Kauhaluoma, Adyary Fallarero, Branka Zorc   +5 more
openaire   +4 more sources

Inhibition of bacterial quorum sensing (general concept)

Zdorovʹe Rebenka, 2019
The scientific review outlines current data characteri­zing the main provisions on the functioning of the mechanism of the sensory quorum in the system of interbacterial communications.
А.Е. Abaturov, Т.А. Kryuchko
doaj   +1 more source

Two homologous Agr-like quorum-sensing systems cooperatively control adherence, cell morphology, and cell viability properties in Lactobacillus plantarum WCFS1

, 2008
A two-component regulatory system of Lactobacillus plantarum, encoded by genes designated lamK and lamR (hpk10 and rrp10), was studied. The lamK and lamR genes encode proteins which are highly homologous to the quorum-sensing histidine kinase LamC and ...
Vos, W.M., de, Kleerebezem, M., Kunuki, Ryoko, Ingham, C.J., Sturme, Mark, Nakayama, J., Vaughan, Elaine, Kunuki, R., Nakayama, Jiro, Sturme, M.H.J., Fujii, Toshio, Kleerebezem, Michiel, Molenaar, D., Fujii, T., Vaughan, E.E., Ingham, Colin, Beerthuyzen, Marke, Molenaar, Douwe, de Vos, Willem, Molenaar, Douwe; id_orcid, de Vos, W.M., Beerthuyzen, M.M.   +21 more
core   +1 more source

SELECTED PHYTOCHEMICAL BIOACTIVE COMPOUNDS AS QUORUM SENSING INHIBITORS [PDF]

Acta Horticulturae, 2012
Fil: Truchado , P.. Consejo Superior de Investigaciones Cientificas.
Truchado , P., Tomás Barberán, F., Allende, A., Ponce, Alejandra Graciela   +3 more
openaire   +2 more sources

Novel approaches for the design and discovery of quorum-sensing inhibitors [PDF]

Expert Opinion on Drug Discovery, 2014
The spread of antibiotic resistance, together with the lack of antibiotics based on novel molecular scaffolds, marks the so-called 'post-antibiotic era'. Interference with bacterial virulence has emerged as an attractive approach among the current potential strategies for developing new anti-infective drugs.
Sara, Scutera, Mario, Zucca, Dianella, Savoia   +2 more
openaire   +2 more sources

Attenuation of quorum sensing using computationally designed polymers [PDF]

, 2010
It is generally accepted that the majority of Gram-negative and Gram-positive bacteria communicate via production and sensing of small signal molecules, autoinducers.
Stavroulakis, Georgios
core  

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Inhibition of marine biofouling by bacterial quorum sensing inhibitors [PDF]

Biofouling, 2011
Seventy eight natural products from chemical libraries containing compounds from marine organisms (sponges, algae, fungi, tunicates and cyanobacteria) and terrestrial plants, were screened for the inhibition of bacterial quorum sensing (QS) using a reporter strain Chromobacterium violaceum CV017.
Dobretsov, Sergey, Teplitski, Max, Bayer, Mirko, Gunasekera, Sarath, Proksch, Peter, Paul, Valerie J.   +5 more
openaire   +3 more sources