Results 51 to 60 of about 1,595,844 (248)

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

Advanced Science, EarlyView.
This study employs a spouse‐pair cohort design and an idopNetwork model that integrates evolutionary game theory, predator‐prey dynamics, and developmental modularity theory to reconstruct maximally informative microbial interaction networks. This approach reveals how interspecies interactions drive the phenotypic plasticity of the gut microbiota in ...
Huizhen Li, Jiayi Li, Ang Dong, Xiaoyan Guo, Qiuyue Tu, Zelin Feng, Haojia Lin, Yanru Zhang, Yuxuan Hao, Huiying Gong, Yihan Meng, Yu Wang, Shing‐Tung Yau, Xiaocang Cao, Rongling Wu, Xinjuan Liu   +15 more
wiley   +1 more source

In Silico Screening of Quorum Sensing Inhibitor Candidates Obtained by Chemical Similarity Search

Molecules, 2022
Quorum sensing (QS) is a bacterial communication using signal molecules, by which they sense population density of their own species, leading to group behavior such as biofilm formation and virulence.
Sharath Belenahalli Shekarappa, Hrvoje Rimac, Julian Lee   +2 more
doaj   +1 more source

SELECTED PHYTOCHEMICAL BIOACTIVE COMPOUNDS AS QUORUM SENSING INHIBITORS [PDF]

Acta Horticulturae, 2012
Fil: Truchado , P.. Consejo Superior de Investigaciones Cientificas.
Truchado , P., Tomás Barberán, F., Allende, A., Ponce, Alejandra Graciela   +3 more
openaire   +2 more sources

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Two homologous Agr-like quorum-sensing systems cooperatively control adherence, cell morphology, and cell viability properties in Lactobacillus plantarum WCFS1 [PDF]

, 2008
A two-component regulatory system of Lactobacillus plantarum, encoded by genes designated lamK and lamR (hpk10 and rrp10), was studied. The lamK and lamR genes encode proteins which are highly homologous to the quorum-sensing histidine kinase LamC and ...
Vos, W.M., de, Kleerebezem, M., Kunuki, Ryoko, Ingham, C.J., Sturme, Mark, Nakayama, J., Vaughan, Elaine, Kunuki, R., Nakayama, Jiro, Sturme, M.H.J., Fujii, Toshio, Kleerebezem, Michiel, Molenaar, D., Fujii, T., Vaughan, E.E., Ingham, Colin, Beerthuyzen, Marke, de Vos, Willem, Molenaar, Douwe; id_orcid, Beerthuyzen, M.M.   +19 more
core   +1 more source

Structural studies of Vibrio cholerae quorum sensing proteins [PDF]

, 2012
The spread of cholera is always associated with contaminated food or water and this is the reason this disease has been endemic in developing countries for centuries due to their lack of proper sanitation facilities and poor or no infrastructure for ...
Jahan, Nasrin
core   +2 more sources

Aromatherapeutic Antibacterials: Comparative Study of 40 Essential Oils and Their Biofilm Inhibition in Pseudomonas aeruginosa ATCC9027

Hayati Journal of Biosciences
Growing evidence suggests that biofilm formation in Pseudomonas aeruginosa (PA) results from quorum sensing, reducing bacterial sensitivity to antibiotics and fostering the development of antibiotic-resistant strains.
Nur Aziz, Rollando, Eva Monica, F.X Haryanto Susanto   +3 more
doaj   +1 more source

Combination Therapy Strategy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Suppressing Multiple Quorum Sensing Pathways of P. aeruginosa [PDF]

Scientific Reports, 2018
Abstract The threat of antibiotic resistant bacteria has called for alternative antimicrobial strategies that would mitigate the increase of classical resistance mechanism. Many bacteria employ quorum sensing (QS) to govern the production of virulence factors and formation of drug-resistant biofilms. Targeting the
July Fong, Chaodong Zhang, Renliang Yang, Zhao Zhi Boo, Soon Keat Tan, Thomas E. Nielsen, Michael Givskov, Xue-Wei Liu, Wu Bin, Haibin Su, Liang Yang   +10 more
openaire   +5 more sources

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway

Scientific Reports, 2017
The main components of the quorum-sensing system are expected to be favorable targets for drug development to combat various chronic infectious diseases.
Seiji Ishii, Kenji Fukui, Satoshi Yokoshima, Kazuo Kumagai, Youko Beniyama, Tetsuya Kodama, Tohru Fukuyama, Takayoshi Okabe, Tetsuo Nagano, Hirotatsu Kojima, Takato Yano   +10 more
doaj   +1 more source