Results 31 to 40 of about 1,595,844 (248)

Interference With Quorum-Sensing Signal Biosynthesis as a Promising Therapeutic Strategy Against Multidrug-Resistant Pathogens

Frontiers in Cellular and Infection Microbiology, 2019
Faced with the global health threat of increasing resistance to antibiotics, researchers are exploring interventions that target bacterial virulence factors.
Osmel Fleitas Martínez, Osmel Fleitas Martínez, Pietra Orlandi Rigueiras, Állan da Silva Pires, William Farias Porto, William Farias Porto, William Farias Porto, Osmar Nascimento Silva, Cesar de la Fuente-Nunez, Cesar de la Fuente-Nunez, Cesar de la Fuente-Nunez, Cesar de la Fuente-Nunez, Cesar de la Fuente-Nunez, Octavio Luiz Franco, Octavio Luiz Franco, Octavio Luiz Franco   +15 more
doaj   +1 more source

Synergy of Quorum Quenching Enzyme and Quorum Sensing Inhibitor in Inhibiting P.aeruginosa Quorum Sensing [PDF]

, 2017
ABSTRACT The threat of antibiotic resistant bacteria has called for alternative antimicrobial strategies that would mitigate the increase of classical resistance mechanism. Many bacteria employ quorum sensing (QS) to govern the production of virulence genes and formation of drug-resistance biofilms.
Fong, July, Zhang, Chaodong, Yang, Renliang, Boo, Zhao Zhi, Tan, Soon Keat, Nielsen, Thomas E., Givskov, Michael, Wu, Bin, Su, Haibin, Yang, Liang   +9 more
openaire   +1 more source

Quorum sensing and its inhibition mechanisms [PDF]

BIO Web of Conferences
The article is a brief literature review. This article provides an overview of the Quorum Sensing system in bacterial communities, highlighting the peculiarities of the system for gram-positive and gramnegative microorganisms. Basic information about the
Prazdnova Evgeniya, Bren Anzhelica, Golovko Lilia, Teperin Alexander, Xu Delin, Zhao Xinqing, Chikindas Michael, Rudoy Dmitry   +7 more
doaj   +1 more source

Identification of novel phenylalanine derivatives bearing a hydroxamic acid moiety as potent quorum sensing inhibitors. [PDF]

RSC Med Chem
Phenylalanine derivatives are a well-known small moiety responsible for controlling the virulence factors of several bacteria. Herein, for the first time, we report novel structures of phenylalanine derivatives bearing a hydroxamic acid moiety which were
Tung TT, Quoc Thang N, Cao Huy N, Bao Phuong P, Ngoc Minh D, Hai Nam N, Nielsen J.   +6 more
europepmc   +2 more sources

Inhibition of bacterial quorum sensing (general concept)

Zdorovʹe Rebenka, 2019
The scientific review outlines current data characteri­zing the main provisions on the functioning of the mechanism of the sensory quorum in the system of interbacterial communications.
А.Е. Abaturov, Т.А. Kryuchko
doaj   +1 more source

Quorum Sensing Interfering Strategies and Their Implications in the Management of Biofilm-Associated Bacterial Infections [PDF]

Brazilian Archives of Biology and Technology, 2020
The bacterial species employ various types of molecular communication systems recognized as quorum sensing for the synchronization of differential gene expression to regulate virulence traits and biofilm formation. A variety of quorum sensing inhibitors;
Samman Munir, Asad Ali Shah, Muhammad Shahid, Irfan Manzoor, Bilal Aslam, Muhammad Hidayat Rasool, Muhammad Saeed, Sultan Ayaz, Mohsin Khurshid   +8 more
doaj   +1 more source

Chloroquine fumardiamides as novel quorum sensing inhibitors

Bioorganic & Medicinal Chemistry Letters, 2020
Quorum sensing inhibitors (QSIs) that specifically interfere with bacterial cell-to-cell communication are considered as an alternative approach to conventional antibacterial therapy. In our study, a set of twenty-six fumardiamides with a quinoline head-group were evaluated as potential QSIs.
Maja Beus, Kirsi Savijoki, Jayendra Z. Patel, Jari Yli-Kauhaluoma, Adyary Fallarero, Branka Zorc   +5 more
openaire   +4 more sources

Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa. [PDF]

Front Cell Infect Microbiol, 2018
Pseudomonas aeruginosa is known as an opportunistic pathogen that often causes persistent infections associated with high level of antibiotic-resistance and biofilms formation. Chemical interference with bacterial cell-to-cell communication, termed quorum sensing (QS), has been recognized as an attractive approach to control infections and address the ...
Fong J, Mortensen KT, Nørskov A, Qvortrup K, Yang L, Tan CH, Nielsen TE, Givskov M.   +7 more
europepmc   +9 more sources

A Critical Call for Mechanistic Investigations of Metal‐Bacteria Interactions

Advanced Materials, EarlyView.
It is well established that the antibacterial properties of metals have tremendous importance for bioengineering applications. What is not as appreciated, however, is the reproducibility crisis in this field's vast literature. In this perspective, we highlight this reproducibility problem, discuss its sources, and suggest solutions towards focused ...
J. Rackwitz, A. Bandyopadhyay, S. Belkin, S. Bose, N. Eliaz, J. L. Gilbert, T. C. Lowe, F. Mücklich, R. J. Turner, C. C. Tasan   +9 more
wiley   +1 more source

Design, Synthesis, and Evaluation of Transition-State Analogs as Inhibitors of the Bacterial Quorum Sensing Autoinducer Synthase CepI [PDF]

, 2020
Quorum sensing is a bacterial signaling system that involves the synthesis and detection of small signal molecules called autoinducers. A main class of autoinducers in Gram-negative bacteria are acylated homoserine lactones, produced by the LuxI family ...
Alec, Esposito, Julia, Stockwell, Nora R., Vail, Sterling, Payne, Scott, Ulrich, Julian, Kellner-Rogers, Erin, Higgins, Alexandra, Estanislau   +7 more
core   +2 more sources