Results 211 to 220 of about 176,593 (250)

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

<i>Legionella</i> employs the multimodal ubiquitination of Sec22b to modulate SNARE pairing. [PDF]

iScience
Kitao T, Iida R, Kondo H, Miura Y, Taka H, Kiiru S, Okamoto T, Arasaki K, Higashi H, Kubori T, Nagai H.   +10 more
europepmc   +1 more source

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Polarized anionic phospholipids and exocytosis are implicated in the polarized recruitment of budding yeast AP180, an endocytic initiator. [PDF]

Mol Biol Cell
Marchando P, Hu G, Yuan F, Ngo JM, Sun Y, Drubin DG.   +5 more
europepmc   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Molecular mechanisms underlying p62-dependent secretion of the Alzheimer-associated ubiquitin variant UBB⁺¹. [PDF]

Proc Natl Acad Sci U S A
Wagh AR, Glickman MH.
europepmc   +1 more source

The Small Molecule H89 Facilitates Mesenchymal Stem Cell-derived Extracellular Vesicle Release and Optimizes Therapeutic Efficacy in Liver Regeneration. [PDF]

J Extracell Vesicles
Fu Y, Ma Y, Zhang J, Liang L, Li T, Guo Z, Li Z, Feng L, Wang Y, He G, Li S, Li Y, Xu X, Liao H, Gao Y.   +14 more
europepmc   +1 more source

CpoS-Inc interactions facilitate host cell modulation during <i>Chlamydia trachomatis</i> infection. [PDF]

Infect Immun
Tijerina X, Jabeena C, Faris R, Xu Z, Smith P, Schnicker NJ, Weber MM.   +6 more
europepmc   +1 more source

VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement. [PDF]

Nat Commun
Vats S, Dionisio P, Lemercier Q, Pineau R, Therreau L, Lipecka J, Cholley B, Moog JB, Wojnacki J, Keime C, Zala D, Bun P, Freire S, Domingues N, Danglot L, Guerrera IC, Delevoye C, Chevet E, Raimundo N, Galli T.   +19 more
europepmc   +1 more source

A pathogenic mutation in α-SNAP impairs membrane lipid binding by concealing a critical hydrophobic loop. [PDF]

Commun Biol
Méndez-Ruette M, Bedoya M, Hinrichsen B, Henzi R, Muñoz-Gutiérrez C, Parga C, Muñoz C, Márquez G, Muñoz RI, Sandoval S, Ross BH, Vivar JP, Mardones GA, Brauchi S, Wyneken Ú, Michaut MA, González W, Bátiz LF.   +17 more
europepmc   +1 more source