Results 91 to 100 of about 45,175 (206)

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

A method for improved clustering and classification of microscopy images using quantitative co-localization coefficients

BMC Research Notes, 2012
Background The localization of proteins to specific subcellular structures in eukaryotic cells provides important information with respect to their function.
Singan Vasanth R, Handzic Kenan, Curran Kathleen M, Simpson Jeremy C   +3 more
doaj   +1 more source

Turing instabilities in a mathematical model for signaling networks

, 2011
GTPase molecules are important regulators in cells that continuously run through an activation/deactivation and membrane-attachment/membrane-detachment cycle. Activated GTPase is able to localize in parts of the membranes and to induce cell polarity.
AB Goryachev, AB Jaffe, AJ Koch, Andreas Rätz, B Sönnichsen, BL Grosshans, C Garmendia-Torres, C Landsberg, G Dziuk, HM Lommerse Piet, JD Murray, JL Bos, K John, L Brusch, M Postma, Matthias Röger, R Lipp, R Wedlich-Soldner, RS Goody, S Pfeffer, S Pfeffer, S Vey, SJ Altschuler, T Butler, U Keller Jürgen, VL Katanaev, Y Mori, Z Guo   +27 more
core   +1 more source

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Role of Seminal Exosomes in Reproduction

Journal of Cellular Physiology, Volume 240, Issue 11, November 2025.
ABSTRACT Exosomes are small lipid bilayer vesicles, ranging from 30 to 150 nm in diameter, that are secreted by various cells and facilitate intercellular communication. They originate from the endosomal system and release their contents into the extracellular environment.
Shayesteh Mehdinejadiani, Nahid Azad, Zeinab Dehghan, Zahra Khosravizadeh, Fatemeh Saberi, Delsuz Rezaee, Tayyebeh Pilehchi, Nasim Goudarzi, Elnaz Salahi, Kobra Mehdinejadiani   +9 more
wiley   +1 more source

Knockdown of Rab9 Recovers Defective Morphological Differentiation Induced by Chemical ER Stress Inducer or PMD-Associated PLP1 Mutant Protein in FBD-102b Cells

Pathophysiology
Small GTP-binding proteins of the Rab family regulate intracellular vesicle trafficking across many aspects of the transport system. Among these, Rab9 is recognized for its role in controlling the transport system not only around the trans-Golgi network ...
Nana Fukushima, Yuki Miyamoto, Junji Yamauchi   +2 more
doaj   +1 more source

Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells [PDF]

, 2012
Carbon nanotubes (CNTs) are at present being considered as potential nanovectors with the ability to deliver therapeutic cargoes into living cells. Previous studies established the ability of CNTs to enter cells and their therapeutic utility, but an ...
A. T. Jones, Andreas Gerondopoulos, B. M. Mullock, B. Soula, C. Bucci, C. N. Connolly, Carmen Tîlmaciu, D. J. Yamashiro, D. Pantarotto, E. F. C. Blommaart, E. Heister, E. Heister, Elena Heister, Emmanuel Flahaut, F. Aniento, F. R. Maxfield, F. Zhou, G. Bartholomeusz, G. Li, H. Jin, H. Jin, H. N. Yehia, H. W. Davidson, Helen M. Coley, J. F. Clarke, J. P. Luzio, J. Saraste, Johnjoe McFadden, K. Kostarelos, L. Lacerda, L. Lacerda, M. Cardone, M. J. Clague, M. J. Quon, M. L. Wei, M. Ren, M. S. Strano, N. W. S. Kam, P. O. Seglen, P. Saftig, Q. Mu, R. G. Parton, R. N. Ghosh, R. Saito, S. K. Doorn, S. Ravi P. Silva, V. Neves, Vera Neves, W. J. Brown, Y. Wu   +49 more
core   +4 more sources

Integrative Transcriptomic and Phosphoproteomic Analysis Reveals Key Components of the SnRK1 Signaling Network in Rice

Plant Direct, Volume 9, Issue 11, November 2025.
ABSTRACT SnRK1 is an evolutionarily conserved protein kinase belonging to the SNF1/AMPK family of protein kinases that is central to adjusting growth in response to the energy status. Numerous studies have shown adaptive and developmental roles of SnRK1, but the understanding of the SnRK1 signaling network in monocots is limited.
Maria C. Faria‐Bates, Chandan Maurya, K. Muhammed Jamsheer, Vibha Srivastava   +3 more
wiley   +1 more source

Inhibition of Ral GTPases Using a Stapled Peptide Approach. [PDF]

, 2016
Aberrant Ras signaling drives numerous cancers, and drugs to inhibit this are urgently required. This compelling clinical need combined with recent innovations in drug discovery including the advent of biologic therapeutic agents, has propelled Ras back ...
Abell, Chris, Clayton, Natasha S, Cooper, Jonathan M, Mott, Helen R, Owen, Darerca, Thomas, Jemima C, Wang, Chensu, White, Michael A   +7 more
core   +2 more sources

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source