Results 91 to 100 of about 24,778 (199)

The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion. [PDF]

, 2017
Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin and HDL cholesterol concentrations, obesity, and coronary atherosclerosis.
Alison Sleigh, Anna Stears, Claire Adams, Felicity Payne, Inês Barroso, Isabel Huang-Doran, Katherine Fawcett, Nuno Rocha, Robert K. Semple, Stephen O’Rahilly, Vladimir Saudek   +10 more
core   +3 more sources

The mechanisms in glucose metabolism of aging hippocampus

Ibrain, Volume 11, Issue 4, Page 457-475, Winter 2025.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
wiley   +1 more source

Functional studies of plasma membrane syntaxins in yeast [PDF]

, 2003
Syntaxins are required for fusion of membranes in eukaryotic cells and belong to a group of proteins known as t-SNAREs. This thesis primarily focuses on the role of the plasma membrane syntaxins Sso1p and Sso2p in the yeast Saccharomyces cerevisiae.
Öyen, Mattias
core  

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a. [PDF]

, 2019
Rab GTPases are compartment-specific molecular switches that regulate intracellular vesicular transport in eukaryotes. GDP/GTP exchange factors (GEFs) control Rab activation, and current models propose that localised and regulated GEF activity is ...
Allaire, Alva, Barr, Bennett, Blümer, Cabrera, Coppola, Del Villar, Evans, Feinstein, Figueiredo, Fukuda, Gerondopoulos, Hammer, Hume, Hume, Hume, Hutagalung, Imai, Ingmundson, Ioannou, Iwasaki, Knodler, Kurada, Larijani, Lavado, Li, Machner, Mahoney, Murata, Novick, Oishi, Ortiz, Pfeffer, Poteryaev, Rink, Robinson, Stenmark, Strom, Tanaka, Tarafder, Wada, Wang, Wu, Wu, Wu, Yamaguchi, Yoshimura, Zhang   +48 more
core   +2 more sources

Breast Cancer‐Secreted DPP3 Promotes Lung Metastasis by Remodelling the Vascular Niche in Lung via the Rap1 Signalling Pathway

Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
ABSTRACT Metastasis is the leading cause of death related to breast cancer. Premetastatic niches (PMNs), which are remodelled by the primary tumours in distant organs, are essential for the colonisation of disseminated cancer cells. The vascular niche is among the most pivotal PMNs in breast cancer lung metastasis, and the underlying mechanism remains ...
Xu Li, Sheng Hu, Ziqi Yuan, Xiaoyu Fu, Xiaohui Zhang, Liu Liu, Chaoqun Wang, Wei Yan, Juanjuan Li   +8 more
wiley   +1 more source

Knockdown of Rab9 Recovers Defective Morphological Differentiation Induced by Chemical ER Stress Inducer or PMD-Associated PLP1 Mutant Protein in FBD-102b Cells

Pathophysiology
Small GTP-binding proteins of the Rab family regulate intracellular vesicle trafficking across many aspects of the transport system. Among these, Rab9 is recognized for its role in controlling the transport system not only around the trans-Golgi network ...
Nana Fukushima, Yuki Miyamoto, Junji Yamauchi   +2 more
doaj   +1 more source

Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis [PDF]

, 2013
The small GTP-binding protein Rab8 is known to play an essential role in intracellular transport and cilia formation. We have previously demonstrated that Rab8a is required for localising apical markers in various organisms.
A. Harada, H. Hagiwara, M. Kunii, M. Yuzaki, R. Harada, R. Mizuguchi, S. Matsuda, T. Iwano, T. Sato, Y. Jung, Y. Yoshihara   +10 more
core   +2 more sources

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, Volume 5, Issue 4, Page 258-266, December 2025.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source

Turing instabilities in a mathematical model for signaling networks

, 2011
GTPase molecules are important regulators in cells that continuously run through an activation/deactivation and membrane-attachment/membrane-detachment cycle. Activated GTPase is able to localize in parts of the membranes and to induce cell polarity.
AB Goryachev, AB Jaffe, AJ Koch, Andreas Rätz, B Sönnichsen, BL Grosshans, C Garmendia-Torres, C Landsberg, G Dziuk, HM Lommerse Piet, JD Murray, JL Bos, K John, L Brusch, M Postma, Matthias Röger, R Lipp, R Wedlich-Soldner, RS Goody, S Pfeffer, S Pfeffer, S Vey, SJ Altschuler, T Butler, U Keller Jürgen, VL Katanaev, Y Mori, Z Guo   +27 more
core   +1 more source

Inhibition of Ral GTPases Using a Stapled Peptide Approach. [PDF]

, 2016
Aberrant Ras signaling drives numerous cancers, and drugs to inhibit this are urgently required. This compelling clinical need combined with recent innovations in drug discovery including the advent of biologic therapeutic agents, has propelled Ras back ...
Abell, Chris, Clayton, Natasha S, Cooper, Jonathan M, Mott, Helen R, Owen, Darerca, Thomas, Jemima C, Wang, Chensu, White, Michael A   +7 more
core   +2 more sources