Results 91 to 100 of about 55,282 (252)
Regulation of TORC2 function and localization by Rab5 GTPases in Saccharomyces cerevisiae. [PDF]
, 2019 The evolutionarily conserved Target of Rapamycin (TOR) complex-2 (TORC2) is an essential regulator of plasma membrane homeostasis in budding yeast (Saccharomyces cerevisiae).
Locke, Melissa N, Thorner, Jeremy
core +1 more source
The Ras protein superfamily: Evolutionary tree and role of conserved amino acids [PDF]
, 2012 The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site.
Fuentes, Gloria +3 more
core +1 more source
FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard +7 more
wiley +1 more source
Microtubule-dependent ribosome localization in C. elegans neurons. [PDF]
, 2017 Subcellular localization of ribosomes defines the location and capacity for protein synthesis. Methods for in vivo visualizing ribosomes in multicellular organisms are desirable in mechanistic investigations of the cell biology of ribosome dynamics. Here,
Ellisman, Mark H +3 more
core +1 more source
Membrane trafficking alterations in breast cancer progression
Frontiers in Cell and Developmental BiologyBreast cancer (BC) is the most common type of cancer in women, and remains one of the major causes of death in women worldwide. It is now well established that alterations in membrane trafficking are implicated in BC progression.
Andreia Ferreira +4 more
doaj +1 more source
Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 4, Page 831-854, April 2025.ABSTRACT Intrinsically disordered regions (IDRs) of proteins remain understudied with enigmatic sequence features relevant to their functions. Members of the myotubularin‐related protein (MTMR) family contain uncharacterized IDRs. After decades of research on their phosphatase activity, recent work on the C‐terminal IDRs of MTMR7 revealed new ...
Daniel Saar +4 more
wiley +1 more source
HUNK Phosphorylates Rubicon to Support Autophagy [PDF]
, 2019 Background: Autophagy is a catabolic cellular recycling pathway that is essential for maintaining intracellular homeostasis. Autophagosome formation is achieved via the coordination of the Beclin-1 protein complex.
Abt, Melissa +5 more
core +1 more source
Enhanced Robust Adaptive Beamforming Designs for General-Rank Signal Model via an Induced Norm of Matrix Errors [PDF]
arXiv, 2021 The robust adaptive beamforming (RAB) problem for general-rank signal model with an uncertainty set defined through a matrix induced norm is considered. The worst-case signal-to-interference-plus-noise ratio (SINR) maximization RAB problem is formulated by decomposing the presumed covariance of the desired signal into a product between a matrix and its
arxiv
Age‐associated accumulation of RAB9 disrupts oocyte meiosis
Aging Cell, Volume 24, Issue 4, April 2025.This study showed that RAB9 protein accumulates in old human and mouse oocytes. RAB9 accumulation disrupted spindle formation, chromosome alignment and actin cap formation, increased ROS levels, decreased mitochondrial membrane potential, ATP content, mtDNA/nDNA ratio and activated the PINK1‐PARKIN pathway. Importantly, knockdown of RAB9 in old oocytes
Min Gao +10 more
wiley +1 more source
TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells [PDF]
, 2014 Rab11a is a key modulator of vesicular trafficking processes, but there is limited information about the guanine nucleotide-exchange factors and GTPase-activating proteins (GAPs) that regulate its GTP-GDP cycle. We observed that in the presence of Mg(2+)
Apodaca, Gerard +9 more
core +1 more source