Results 91 to 100 of about 25,142 (177)

The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion. [PDF]

, 2017
Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin and HDL cholesterol concentrations, obesity, and coronary atherosclerosis.
Alison Sleigh, Anna Stears, Claire Adams, Felicity Payne, Inês Barroso, Isabel Huang-Doran, Katherine Fawcett, Nuno Rocha, Robert K. Semple, Stephen O’Rahilly, Vladimir Saudek   +10 more
core   +3 more sources

Knockdown of Rab9 Recovers Defective Morphological Differentiation Induced by Chemical ER Stress Inducer or PMD-Associated PLP1 Mutant Protein in FBD-102b Cells

Pathophysiology
Small GTP-binding proteins of the Rab family regulate intracellular vesicle trafficking across many aspects of the transport system. Among these, Rab9 is recognized for its role in controlling the transport system not only around the trans-Golgi network ...
Nana Fukushima, Yuki Miyamoto, Junji Yamauchi   +2 more
doaj   +1 more source

Inhibition of Ral GTPases Using a Stapled Peptide Approach. [PDF]

, 2016
Aberrant Ras signaling drives numerous cancers, and drugs to inhibit this are urgently required. This compelling clinical need combined with recent innovations in drug discovery including the advent of biologic therapeutic agents, has propelled Ras back ...
Abell, Chris, Clayton, Natasha S, Cooper, Jonathan M, Mott, Helen R, Owen, Darerca, Thomas, Jemima C, Wang, Chensu, White, Michael A   +7 more
core   +2 more sources

Research Advances of the Autophagy‐Regulated Radiosensitivity

Cell Proliferation, Volume 58, Issue 10, October 2025.
Autophagy plays a dual role in regulating cellular radiosensitivity in radiotherapy (RT). We discuss the mechanisms by which autophagy promotes survival and growthsuppression by modulating radiosensitivity. It also outlines some frontier autophagy‐targeted radiotherapies. ABSTRACT Autophagy is an evolutionarily conserved process of cell self‐catabolism
Hanyue Liu, Yanlan Xiao, Chuhao Dai, Keyu Chen, Xinyi Xu, Jianming Cai, Xuguang Hu, Jiaming Guo   +7 more
wiley   +1 more source

The Rab-binding profiles of bacterial virulence factors during infection [PDF]

, 2016
Legionella pneumophila, the causative agent of Legionnaire's disease, uses its type IV secretion system to translocate over 300 effector proteins into host cells.
Broncel, M, Carson, D, Frankel, GM, Mattheis, C, Mousnier, A, Schroeder, GN, So, EC, Tate, EW   +7 more
core   +1 more source

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons. [PDF]

, 2016
Intronic hexanucleotide expansions in C9ORF72 are common in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, but it is unknown whether loss of function, toxicity by the expanded RNA or dipeptides from non-ATG-initiated translation are ...
A Burberry, A Michalski, AE Renton, AR Haeusler, BJ Agnew, C Lagier-Tourenne, CJ Donnelly, D Hornburg, D Zhang, DJ Hernández-Deviez, E Majounie, E Sudria-Lopez, EC Keilhauer, EH Franssen, F Tronche, H Radhakrishna, I Gijselinck, J Cox, J Cox, J Cox, J Japtok, J Jiang, J Rappsilber, JG O'Rourke, JJ Bravo-Cordero, K Mori, K Moriyama, K Nunoue, KC Flynn, LA Cingolani, LC Santy, M Bourmoum, M DeJesus-Hernandez, M Fischer, M Innocenti, M Innocenti, M Koppers, M Therrien, MA Farg, ML Rogers, N Subramanian, N Wächter, N Yang, O Al-Awar, O Bernard, P Fratta, P Reinhardt, P Reinhardt, PM Sullivan, R Götz, S Ciura, S Iden, S Jablonka, S Lewis-Saravalli, S May, S Stern, S Tyanova, S Wiese, SC Ling, T Zu, TP Levine, W Huang, X Lojewski, X Wen   +63 more
core   +1 more source

The Role of the Early Secretory Pathway in Foot-and-Mouth Disease Virus Replication

, 2011
Foot-and-Mouth Disease Virus (FMDV) induces rearrangements of host-cell membranes to generate vesicles that are believed to provide platforms for formation of the viral replication complex. The cellular origin of these vesicles and the properties that
Midgley, Rebecca Julie, Midgley, Rebecca Julie   +1 more
core   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Purification of TrkA intracellular domain and the characterization of novel intracellular proteins : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University [PDF]

, 1999
Nerve growth factor (NGF) binds to its receptor, TrkA, at the tips of nerve cell axons to inhibit apoptosis, causing survival and differentiation.
Walker, Scott David
core  

Exosome Biogenesis, Regulation, and Function in Viral Infection [PDF]

, 2015
Exosomes are extracellular vesicles released upon fusion of multivesicular bodies(MVBs) with the cellular plasma membrane. They originate as intraluminal vesicles (ILVs) duringthe process of MVB formation.
Alenquer, Marta, Amorim, Maria
core   +2 more sources