The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story. [PDF]
, 2013 von Willebrand factor (VWF) plays key roles in both primary and secondary hemostasis by capturing platelets and chaperoning clotting factor VIII, respectively.
Cutler, D, Nightingale, T
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A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells [PDF]
, 2008 Mannose 6-phosphate receptors (MPRs) are transported from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This process requires Rab9 guanosine triphosphatase (GTPase) and the putative tether GCC185.
Espinosa, Eric +2 more
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Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis [PDF]
, 2013 The small GTP-binding protein Rab8 is known to play an essential role in intracellular transport and cilia formation. We have previously demonstrated that Rab8a is required for localising apical markers in various organisms.
A. Harada +10 more
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The Role of the Early Secretory Pathway in Foot-and-Mouth Disease Virus Replication
, 2011 Foot-and-Mouth Disease Virus (FMDV) induces rearrangements of host-cell membranes to generate vesicles that are believed to provide platforms for formation of the viral replication complex. The cellular origin of these vesicles and the properties that
Midgley, Rebecca Julie +1 more
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The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion. [PDF]
, 2017 Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin and HDL cholesterol concentrations, obesity, and coronary atherosclerosis.
Alison Sleigh +10 more
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C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons. [PDF]
, 2016 Intronic hexanucleotide expansions in C9ORF72 are common in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, but it is unknown whether loss of function, toxicity by the expanded RNA or dipeptides from non-ATG-initiated translation are ...
A Burberry +63 more
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Purification of TrkA intracellular domain and the characterization of novel intracellular proteins : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University [PDF]
, 1999 Nerve growth factor (NGF) binds to its receptor, TrkA, at the tips of nerve cell axons to inhibit apoptosis, causing survival and differentiation.
Walker, Scott David
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The Rab-binding profiles of bacterial virulence factors during infection [PDF]
, 2016 Legionella pneumophila, the causative agent of Legionnaire's disease, uses its type IV secretion system to translocate over 300 effector proteins into host cells.
Broncel, M +7 more
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, 2011 My PhD project was aimed at applying microfluidics technology to the study of longrange neurotrophin signalling. Neurotrophins are target-derived growth and survival factors that, among other functions, prevent innervating neurons from undergoing ...
Menendez, Guillermo, Menendez, Guillermo
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Functional studies of plasma membrane syntaxins in yeast [PDF]
, 2003 Syntaxins are required for fusion of membranes in eukaryotic cells and belong to a group of proteins known as t-SNAREs. This thesis primarily focuses on the role of the plasma membrane syntaxins Sso1p and Sso2p in the yeast Saccharomyces cerevisiae.
Öyen, Mattias
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