Results 111 to 120 of about 55,282 (252)

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B [PDF]

, 2010
Apicomplexan parasites belong to a recently recognised group of protozoa referred to as Alveolata. These protists contain membranous sacs (alveoli) beneath the plasma membrane, termed the Inner Membrane Complex (IMC) in the case of Apicomplexa.
A Colosimo, A Herm-Gotz, AT Heaslip, B Striepen, Bernardo J. Foth, BL Grosshans, C Agop-Nersesian, C Bucci, C Hettmann, Carolina Agop-Nersesian, D Soldati, David J. P. Ferguson, DJ Ferguson, DJ Ferguson, DS Roos, E Gaskins, E Merithew, F Baluska, GG van Dooren, Gordon Langsley, H Stenmark, HA Schmidt, HE Bullen, J Felsenstein, JB Dacks, JB Dacks, JJ Dumas, JL Gordon, K Hu, K Hu, K Kim, K Lal, L Pelletier, L Sheiner, L. David Sibley, LH Bannister, M Cyrklaff, M Meissner, M Meissner, M Nishi, Markus Meissner, MJ Gubbels, MS Breinich, NS Morrissette, NS Morrissette, NS Morrissette, P van der Sluijs, R Chenna, RD Page, RG Donald, RG Donald, Saskia Egarter, SB Gould, SL Pfluger, SM Adl, T Cavalier-Smith, T Cavalier-Smith, T Mann, Y Saito-Nakano   +58 more
core   +3 more sources

Mechanisms of Resistance to KRAS Inhibitors: Cancer Cells' Strategic Use of Normal Cellular Mechanisms to Adapt

Cancer Science, Volume 116, Issue 3, Page 600-612, March 2025.
This review article covers KRAS mutations, their variable prevalence and effects in different cancers, and the development of KRAS inhibitors. It focuses on mechanisms of resistance—intrinsic, adaptive, and acquired—explaining both genetic and nongenetic causes, with a particular emphasis on lineage plasticity.
Noritaka Tanaka, Hiromichi Ebi
wiley   +1 more source

Purification of TrkA intracellular domain and the characterization of novel intracellular proteins : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Molecular Biology at Massey University [PDF]

, 1999
Nerve growth factor (NGF) binds to its receptor, TrkA, at the tips of nerve cell axons to inhibit apoptosis, causing survival and differentiation.
Walker, Scott David
core  

Atypical Rho GTPases of the RhoBTB Subfamily: Roles in vesicle trafficking and tumorigenesis [PDF]

, 2016
RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependent ...
Ji, Wei, Rivero, Francisco
core   +2 more sources

Knockdown of Rab9 Recovers Defective Morphological Differentiation Induced by Chemical ER Stress Inducer or PMD-Associated PLP1 Mutant Protein in FBD-102b Cells

Pathophysiology
Small GTP-binding proteins of the Rab family regulate intracellular vesicle trafficking across many aspects of the transport system. Among these, Rab9 is recognized for its role in controlling the transport system not only around the trans-Golgi network ...
Nana Fukushima, Yuki Miyamoto, Junji Yamauchi   +2 more
doaj   +1 more source

Optimal offline virtual network embedding with rent-at-bulk aspects [PDF]

arXiv, 2015
Network virtualization techniques allow for the coexistence of many virtual networks (VNs) jointly sharing the resources of an underlying substrate network. The Virtual Network Embedding problem (VNE) arises when looking for the most profitable set of VNs to embed onto the substrate. In this paper, we address the offline version of the problem.
arxiv  

Small GTP-binding proteins are associated with chitosomes and vesicles carrying glucose oxidase from Mucor circinelloides.

Microbiology, 2008
Fractions enriched with chitosomes and vesicles carrying glucose oxidase (GOX) activity from the dimorphic zygomycete Mucor circinelloides were obtained using two successive sucrose gradients, the first a linear-log and the second an isopycnic gradient ...
Rocío Moreno-Jiménez, J. García‐Soto, G. Martínez-Cadena   +2 more
semanticscholar   +1 more source

Proteomic Profiling of Extracellular Vesicles Reveals Potential Biomarkers for Helicobacter pylori Infection and Gastric Cancer

Helicobacter, Volume 30, Issue 2, March/April 2025.
ABSTRACT Background Helicobacter pylori (H. pylori) has been identified as a type I carcinogen and contributes to a high rate of gastric cancer (GC), especially in Eastern Asia. Extracellular vesicles (EVs) have the potential to be used to detect various cancer types and diseases. However, the protein markers in EVs for the prognosis of H.
Phawinee Subsomwong, Krisana Asano, Junko Akada, Takashi Matsumoto, Akio Nakane, Yoshio Yamaoka   +5 more
wiley   +1 more source

Endocrinology and the brain: Corticotropin-Releasing Hormone signaling [PDF]

, 2017
Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral
Armando, Natalia Giannina, Dos Santos Claro, Paula Ayelen, Inda, María Carolina, Silberstein Cuña, Susana Iris   +3 more
core   +2 more sources