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Journal of Bioinformatics and Computational Biology, 2019
Deep learning has been increasingly and widely used to solve numerous problems in various fields with state-of-the-art performance. It can also be applied in bioinformatics to reduce the requirement for feature extraction and reach high performance. This study attempts to use deep learning to predict GTP binding sites in Rab proteins, which is one of ...
Nguyen Quoc Khanh Le +2 more
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Deep learning has been increasingly and widely used to solve numerous problems in various fields with state-of-the-art performance. It can also be applied in bioinformatics to reduce the requirement for feature extraction and reach high performance. This study attempts to use deep learning to predict GTP binding sites in Rab proteins, which is one of ...
Nguyen Quoc Khanh Le +2 more
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Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily
Journal of Cell Science, 1993ABSTRACT Small GTPases of the rab subfamily are involved in reg-ulation of intracellular membrane transport events. We recently used a PCR approach to isolate short cDNA fragments of a number of novel rab sequences. These PCR fragments have now been used with cDNA library screening and PCR-based techniques to clone the cDNAs encoding ...
V M, Olkkonen +5 more
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Molecular Genetics and Genomics, 2004
Rab-related small GTP-binding proteins are known to be involved in the regulation of the vesicular transport system in eucaryotic cells. In this paper we report the isolation of the cDNA clone MS- rab11f from Medicago sativa (alfalfa) root nodules using a combination of RT-PCR and SSCP analysis.
Schiene, K. +4 more
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Rab-related small GTP-binding proteins are known to be involved in the regulation of the vesicular transport system in eucaryotic cells. In this paper we report the isolation of the cDNA clone MS- rab11f from Medicago sativa (alfalfa) root nodules using a combination of RT-PCR and SSCP analysis.
Schiene, K. +4 more
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Gene cloning and characterization of a GTP-binding Rab protein from mouse pituitary AtT-20 cells
Gene, 1993The Rab proteins constitute a family of Ras-like, low-molecular-weight GTP-binding proteins that are involved in vesicular transport in mammalian cells. Several members of this family have been localized to specific cellular compartments, indicating that they may control vesicular transfer between discrete portions of the endomembrane systems.
H, Yu, D S, Leaf, H P, Moore
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The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach
Gene, 1992Partial sequences corresponding to eleven novel Rab proteins and one new Rho protein have been isolated using a PCR-based cloning approach. These results confirm that the overall diversity of the Rab and Rho protein subfamilies account for more than thirty different members in mammalian cells.
P, Chavrier, K, Simons, M, Zerial
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Archives of Biochemistry and Biophysics, 1993
The two early endosome-associated rab GTP-binding proteins, rab4 and rab5, are suggested to regulate endocytosis. In this report, we examined post-translational processing and membrane association of the two rab proteins. Human rab4 and rab5 were expressed in chicken embryo fibroblasts using a Sindbis virus expression vector.
G, Li, P D, Stahl
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The two early endosome-associated rab GTP-binding proteins, rab4 and rab5, are suggested to regulate endocytosis. In this report, we examined post-translational processing and membrane association of the two rab proteins. Human rab4 and rab5 were expressed in chicken embryo fibroblasts using a Sindbis virus expression vector.
G, Li, P D, Stahl
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Biochemical and Biophysical Research Communications, 2002
A variety of intracellular membrane trafficking pathways are involved in establishing the polarization of resorbing osteoclasts and regulating bone resorption activities. Small GTP-binding proteins of rab family have been implicated as key regulators of membrane trafficking in mammalian cells.
Haibo, Zhao +2 more
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A variety of intracellular membrane trafficking pathways are involved in establishing the polarization of resorbing osteoclasts and regulating bone resorption activities. Small GTP-binding proteins of rab family have been implicated as key regulators of membrane trafficking in mammalian cells.
Haibo, Zhao +2 more
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Cytogenetic and Genome Research, 1996
Many subgroups of the RAB gene, a member of the RAS superfamily have been identified. Here we report the isolation and analysis of a cDNA encoding a putative small GTP-binding protein, designated RABL, from a human fetal lung cDNA library. RABL encodes 216 amino acids that are 86 % identical to members of the RAB5 subfamily and it shows 94% homology in
H J, Han +3 more
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Many subgroups of the RAB gene, a member of the RAS superfamily have been identified. Here we report the isolation and analysis of a cDNA encoding a putative small GTP-binding protein, designated RABL, from a human fetal lung cDNA library. RABL encodes 216 amino acids that are 86 % identical to members of the RAB5 subfamily and it shows 94% homology in
H J, Han +3 more
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Russian Journal of Plant Physiology, 2008
In plants, Rab proteins represent the largest family of monomeric GTP-binding proteins (mG-proteins). As distinct from animal cells comprising 40 subfamilies of Rab proteins, which are the key regulators of intracellular vesicular transport, numerous Rab proteins in Arabidopsis and other plant species could be grouped in only eight subfamilies on the ...
I. E. Moshkov, G. V. Novikova
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In plants, Rab proteins represent the largest family of monomeric GTP-binding proteins (mG-proteins). As distinct from animal cells comprising 40 subfamilies of Rab proteins, which are the key regulators of intracellular vesicular transport, numerous Rab proteins in Arabidopsis and other plant species could be grouped in only eight subfamilies on the ...
I. E. Moshkov, G. V. Novikova
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Identification of a novel family of human Rab-like small GTP-binding proteins.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1999The presence of a novel family of Rab-like proteins (Rlp) in the human genome is reported. The gene encoding the Rlp-2 was isolated from a human lymphocyte genomic library. The Rlp-2 gene is intronless and was mapped to chromosome Xq21.3 using fluorescence in situ hybridization.
H L, Peng +3 more
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