Results 171 to 180 of about 45,175 (206)

Using two-dimensional convolutional neural networks for identifying GTP binding sites in Rab proteins

open access: closedJournal of Bioinformatics and Computational Biology, 2018
Deep learning has been increasingly and widely used to solve numerous problems in various fields with state-of-the-art performance. It can also be applied in bioinformatics to reduce the requirement for feature extraction and reach high performance. This
Nguyen Quoc Khanh Le   +2 more
semanticscholar   +4 more sources

Expression of rab GTP-binding proteins during oligodendrocyte differentiation in culture

open access: closedJournal of Neuroscience Research, 2000
Oligodendrocytes (OLs) synthesize and transport vast amounts of proteins and lipids from the cell body to the morphologically and biochemically distinct domains of the myelin membrane. From our prediction that regulators of vesicular transport should be up-regulated at the time of myelin production, we hypothesized that the up-regulated and ...
B.P. Bouverat   +4 more
semanticscholar   +5 more sources

Post-translational Processing and Membrane Association of the Two Early Endosome-Associated rab GTP-Binding Proteins (rab4 and rab5)

open access: closedArchives of Biochemistry and Biophysics, 1993
The two early endosome-associated rab GTP-binding proteins, rab4 and rab5, are suggested to regulate endocytosis. In this report, we examined post-translational processing and membrane association of the two rab proteins. Human rab4 and rab5 were expressed in chicken embryo fibroblasts using a Sindbis virus expression vector.
G.P. Li, Philip D. Stahl
semanticscholar   +4 more sources

Evolution of the rab family of small GTP-binding proteins

open access: closedJournal of Molecular Biology, 2001
Rab proteins are small GTP-binding proteins that form the largest family within the Ras superfamily. Rab proteins regulate vesicular trafficking pathways, behaving as membrane-associated molecular switches. Here, we have identified the complete Rab families in the Caenorhabditis elegans (29 members), Drosophila melanogaster (29), Homo sapiens (60) and ...
José B. Pereira‐Leal   +1 more
semanticscholar   +4 more sources

An immunologist's look at the Rho and Rab GTP-binding proteins

open access: closedImmunology Today, 1993
The ras superfamily of small GTP-binding proteins contains three major branches: the Ras, Rho and Rab protein subfamilies. Recent advances in the field of ras-related small GTP-binding proteins suggest that it may be worthwhile to look at this superfamily from the standpoint of immunology.
Philippe Chavrier   +2 more
semanticscholar   +4 more sources

Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2

open access: closedNature, 1991
Entry of a cell into mitosis induces a series of structural and functional changes including arrest of intracellular transport. Knowledge of how the mitotic cycle is driven progressed substantially with the identification of the p34cdc2 protein kinase as a subunit of maturation-promoting factor, the universal regulating component of the mitotic cycle ...
Éric Bailly   +5 more
semanticscholar   +4 more sources

Superfamily of plant monomeric GTP-binding proteins: 2. Rab proteins are the regulators of vesicles trafficking and plant responses to stresses

open access: closedRussian Journal of Plant Physiology, 2008
In plants, Rab proteins represent the largest family of monomeric GTP-binding proteins (mG-proteins). As distinct from animal cells comprising 40 subfamilies of Rab proteins, which are the key regulators of intracellular vesicular transport, numerous Rab proteins in Arabidopsis and other plant species could be grouped in only eight subfamilies on the ...
И. Е. Мошков   +1 more
semanticscholar   +3 more sources

A rab-related GTP-binding protein in Schistosoma mansoni

open access: closedMolecular and Biochemical Parasitology, 1996
Schistosomiasis is a parasitic disease initiated by the deposition of eggs in host tissues by the blood fluke Schistosoma. A gene encoding a low-molecular weight GTP-binding protein (LMWGP) was cloned from Schistosoma mansoni using a polymerase chain reaction (PCR)-based strategy.
Loeffler Ik
  +5 more sources

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