Results 11 to 20 of about 25,142 (177)

The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes [PDF]

Nature Communications
Small GTP-binding proteins of the Rab, Arf, and Arf-like family mediate the recruitment of their effectors to subcellular membrane-bound compartments, which in turn mediate vesicle budding, motility, and tethering.
Sankalita Paul, Rajat Pant, Poonam Sharma, Kshitiz Walia, Suhasi Gupta, Adhil Aseem, Kamlesh Kumari Bajwa, Ruben George, Yudish Varma, Tripta Bhatia, Rajesh Ramachandran, Amit Tuli, Mahak Sharma   +12 more
doaj   +2 more sources

rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids.

Journal of Biological Chemistry, 1992
p21ras and several other ras-related GTP-binding proteins are modified post-translationally by addition of 15-carbon farnesyl or 20-carbon geranylgeranyl isoprenoids to cysteines within a conserved carboxyl-terminal sequence motif, Caa(M/S/L), where a is an aliphatic amino acid.
B. Therese Kinsella, William A. Maltese
openalex   +3 more sources

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets. [PDF]

MedComm (2020)
This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Lin Z, Ni C, Jiang H, Yang H, Deng L, Liu P, Li X, Yu Y, Li W, Wang R, Liao B, Kang J, Liu J, Wu X, Ren J, Zhao Y.   +15 more
europepmc   +2 more sources

GTP cycling protein (GCP): An ancient player for allosteric gatekeeping. [PDF]

mLife
mLife, Volume 4, Issue 5, Page 511-515, October 2025.
Liu JL.
europepmc   +2 more sources

Characterization of lysosomal membrane proteins of Dictyostelium discoideum. A complex population of acidic integral membrane glycoproteins, Rab GTP-binding proteins and vacuolar ATPase subunits.

Journal of Biological Chemistry, 1994
Highly purified lysosomes, prepared by magnetic fractionation of homogenates from Dictyostelium discoideum cells fed colloidal iron, were lysed under hypoosmotic conditions, and the membrane-associated proteins were subjected to gel electrophoresis. Thirteen major membrane polypeptides, ranging in molecular weight from 25,000 to 100,000 were identified.
Lesly A. Temesvari, Juan Rodriguez‐Paris, John Bush, Theodore L. Steck, James A. Cardelli   +4 more
openalex   +3 more sources

TBC1D22B Regulates ER-to-Golgi Trafficking via RAB1B Inactivation and Promotes Oncogenic Programs in Breast Cancer. [PDF]

Adv Sci (Weinh)
TBC1D22B, a Golgi‐localized RabGAP linked to poor prognosis in breast cancer, inhibits ER‐to‐Golgi transport via RAB1B inactivation. This disrupts secretion, drives oncogenic transcriptional reprogramming, and promotes tumor growth. These findings indicate that TBC1D22B connects membrane trafficking to transcriptional control and cancer progression ...
Martino F, Lupi M, Murabito A, Bedin F, Villari G, Andreoli L, Freddi S, Matoskova B, Pennisi R, Fontana S, Fardin A, Boncompain G, Perez F, Bussolino F, Cuomo A, Sigismund S, Lanzetti L.   +16 more
europepmc   +2 more sources

Rabphilin-3A, a Putative Target Protein for smg p25A/rab3A p25 Small GTP-Binding Protein Related to Synaptotagmin

Molecular and Cellular Biology, 1993
In a previous study (H. Shirataki, K. Kaibuchi, T. Yamaguchi, K. Wada, H. Horiuchi, and Y. Takai, J. Biol. Chem. 267:10946-10949, 1992), we highly purified from bovine brain crude membranes the putative target protein for smg p25A/rab3A p25, a ras p21-related small GTP-binding protein implicated in neurotransmitter release.
Hiromichi Shirataki, Kozo Kaibuchi, Tsuyoshi Sakoda, Shosei Kishida, Tsutomu Yamaguchi, Ken Wada, Mutsuo Miyazaki, Yoshimi Takai   +7 more
openalex   +5 more sources

Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells

European Journal of Cell Biology, 2000
Rab proteins belong to a subfamily of small GTP-binding protein genes of the Ras superfamily and play an important role in intracellular vesicular targeting. The presence of members of this protein family was examined in Caco-2 cells by a PCR-based strategy.
Frank J.M. Opdam, Gera Kamps, Huib J. E. Croes, Hans van Bokhoven, Leo A. Ginsel, Jack Fransen   +5 more
openalex   +4 more sources

Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement

iScience, 2022
Summary: Mutations in LRRK2 increase its kinase activity and cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab proteins which allows for their binding to RILPL1.
Elena Fdez, Jesús Madero-Pérez, Antonio J. Lara Ordóñez, Yahaira Naaldijk, Rachel Fasiczka, Ana Aiastui, Javier Ruiz-Martínez, Adolfo López de Munain, Sally A. Cowley, Richard Wade-Martins, Sabine Hilfiker   +10 more
doaj   +1 more source

Rab GTPases, tethers, and SNAREs work together to regulate Arabidopsis cell plate formation

Frontiers in Plant Science, 2023
Cell plates are transient structures formed by the fusion of vesicles at the center of the dividing plane; furthermore, these are precursors to new cell walls and are essential for cytokinesis.
Yumei Shi, Changxin Luo, Yun Xiang, Dong Qian   +3 more
doaj   +1 more source