Results 11 to 20 of about 45,175 (206)
Molecules and Cells, 1997 To study physiological roles of plant small GTP binding proteins, we isolated a cDNA clone (ORrab2) encoding the rab-related small GTP binding protein from rice (Oryza sativa L. IR-36) by using human cDNA rab2 as a probe. The deduced amino acid sequence of the ORrab2 gene shared all the conserved regions, important for GTPase/GTP binding activities ...
Ho Yeon Kim +5 more
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Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins. [PDF]
Proceedings of the National Academy of Sciences, 1993 The activation of platelets by specific agonists is a tightly regulated mechanism that leads to the secretion of the dense- and alpha-granule contents. Platelets have been shown to possess small GTP-binding proteins thought to be involved in central biological processes; however, no rab proteins, which may regulate the exocytic process at different ...
A. Karniguian +2 more
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GDP/GTP exchange reaction‐stimulating activity of Rabphilin‐3A for Rab3A small GTP‐binding protein [PDF]
FEBS Letters, 1994 Rabphilin‐3A is a putative target protein for Rab3A, a small GTP‐binding protein particularly implicated in neurotransmitter release. Rabphilin‐3A interacts more preferentially with GTP‐Rab3A than with GDP‐Rab3A. Moreover, Rabphilin‐3A shows a weak activity to stimulate the GTPase activity of Rab3A and a strong activity to inhibit the Rab3A GTPase ...
Yasuyuki Fujita +7 more
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Role of the Rab GTP-Binding Protein Ypt3 in the Fission Yeast Exocytic Pathway and Its Connection to Calcineurin Function [PDF]
Molecular Biology of the Cell, 2002 A genetic screen for mutations synthetically lethal with fission yeast calcineurin deletion led to the identification of Ypt3, a homolog of mammalian Rab11 GTP-binding protein. A mutant with the temperature-sensitive ypt3-i5 allele showed pleiotropic phenotypes such as defects in cytokinesis, cell wall integrity, and vacuole fusion, and these were ...
Hong Cheng +9 more
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Journal of Biological Chemistry, 1991 Low molecular mass GTP-binding proteins encoded by the mammalian rab genes are found in membranes of the Golgi complex and endosomes, suggesting that they play a role in the movement of exocytic and endocytic vesicles. The basis for the membrane association of these proteins has not been defined.
B. Therese Kinsella, William A. Maltese
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Molecular and Cellular Biology, 1993 In a previous study (H. Shirataki, K. Kaibuchi, T. Yamaguchi, K. Wada, H. Horiuchi, and Y. Takai, J. Biol. Chem. 267:10946-10949, 1992), we highly purified from bovine brain crude membranes the putative target protein for smg p25A/rab3A p25, a ras p21-related small GTP-binding protein implicated in neurotransmitter release.
Hiromichi Shirataki +7 more
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Location of light-repressible, small GTP-binding protein of the YPT/rab family in the growing zone of etiolated pea stems. [PDF]
Proceedings of the National Academy of Sciences, 1995 YPT/rab proteins are ras-like small GTP-binding proteins that serve as key regulators of vesicular transport. The mRNA levels of two YPT/rab genes in pea plants are repressed by light, with the process mediated by phytochrome. Here, we examined the mRNA expression and the location of the two proteins, pra2- and pra3-encoded proteins, using monoclonal ...
Yukio Nagano +4 more
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Myofibroblast-Derived Extracellular Vesicles Drive Profibrotic Cascade Amplification in Pulmonary Fibrosis via the Nestin-Rab7 Axis. [PDF]
J Extracell VesiclesABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease characterized by aberrant myofibroblast activation and excessive extracellular matrix deposition, with extracellular vesicles (EVs) playing a crucial role in this pathological process. We observed that EVs levels are significantly elevated in IPF and positively correlate with
Lai X +14 more
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Affinity-based proteomics reveals novel binding partners for Rab46 in endothelial cells
Scientific Reports, 2021 Rab46 is a novel Ca2+-sensing Rab GTPase shown to have important functions in endothelial and immune cells. The presence of functional Ca2+-binding, coiled-coil and Rab domains suggest that Rab46 will be important for coupling rapid responses to ...
Lucia Pedicini +4 more
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European Journal of Entomology, 2023 Rab, a low molecular weight GTP-binding protein, regulates the transmission of intracellular proteins. Insect neuropeptides that are directly involved in growth, development, reproduction, homeostasis, courtship, feeding, circadian rhythm and many other ...
Asuka MATSUI +6 more
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