Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [PDF]
, 2007 Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the ...
Barr, Francis A. +5 more
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Journal of Lipid Research, 2008 Formation of covalently bound protein adducts with lithocholic acid (LCA) might explain LCA's known carcinogenic properties and hepatotoxicity. We performed studies aimed at isolating and identifying hepatic proteins tagged with LCA, presumably via the ε-
Shigeo Ikegawa +6 more
doaj +1 more source
Mutational Analysis of Rab3 Function for Controlling Active Zone Protein Composition at the Drosophila Neuromuscular Junction. [PDF]
PLoS ONE, 2015 At synapses, the release of neurotransmitter is regulated by molecular machinery that aggregates at specialized presynaptic release sites termed active zones.
Shirui Chen +4 more
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The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. [PDF]
, 2016 Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P).
Novick, Peter J, Stalder, Danièle
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A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. [PDF]
, 2014 Insulin-stimulated glucose uptake in fat and muscle is mediated by the major facilitative glucose transporter Glut4. Insulin controls the trafficking of Glut4 to the plasma membrane via regulation of a series of small G proteins, including RalA and Rab10.
Chen, Xiao-Wei +6 more
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Alteraciones en el reclutamiento y activación de proteínas Rab durante la infección micobacteriana
Biomédica: revista del Instituto Nacional de Salud, 2010 En el fagosoma, Mycobacterium spp. altera la activación y reclutamiento de diferentes proteínas "del gen Ras de cerebro de rata", comúnmente conocidas como Rab.
Diana Castaño, Mauricio Rojas
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Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation [PDF]
, 2015 Rab GTPases control membrane identity, fusion, and transport by interaction with effector proteins. Effectors that influence the activation/inactivation cycle of their own or other Rabs contribute to the timely conversion of Rab identities.
Buser, Dominik P. +3 more
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Rabs, Rips, FIPs, and Endocytic Membrane Traffic
The Scientific World Journal, 2003 Rab GTPases, proteins belonging to the Ras-like small GTP-binding protein superfamily, have emerged as master regulators of cellular membrane transport.
Rytis Prekeris
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Human Golgi phosphoprotein 3 is an effector of RAB1A and RAB1B.
PLoS ONE, 2020 Golgi phosphoprotein 3 (GOLPH3) is a peripheral membrane protein localized at the trans-Golgi network that is also distributed in a large cytosolic pool.
Viviana A Cavieres +7 more
doaj +1 more source
Regulation of polarised growth in fungi [PDF]
, 2008 Polarised growth in fungi occurs through the delivery of secretory vesicles along tracks formed by cytoskeletal elements to specific sites on the cell surface where they dock with a multiprotein structure called the exocyst before fusing with the ...
Adamo +112 more
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