Mutational Analysis of Rab3 Function for Controlling Active Zone Protein Composition at the Drosophila Neuromuscular Junction. [PDF]
PLoS ONE, 2015 At synapses, the release of neurotransmitter is regulated by molecular machinery that aggregates at specialized presynaptic release sites termed active zones.
Shirui Chen +4 more
doaj +1 more source
The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. [PDF]
, 2016 Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P).
Novick, Peter J, Stalder, Danièle
core +2 more sources
A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. [PDF]
, 2014 Insulin-stimulated glucose uptake in fat and muscle is mediated by the major facilitative glucose transporter Glut4. Insulin controls the trafficking of Glut4 to the plasma membrane via regulation of a series of small G proteins, including RalA and Rab10.
Chen, Xiao-Wei +6 more
core +1 more source
Alteraciones en el reclutamiento y activación de proteínas Rab durante la infección micobacteriana
Biomédica: revista del Instituto Nacional de Salud, 2010 En el fagosoma, Mycobacterium spp. altera la activación y reclutamiento de diferentes proteínas "del gen Ras de cerebro de rata", comúnmente conocidas como Rab.
Diana Castaño, Mauricio Rojas
doaj +1 more source
TBC1D22B Regulates ER-to-Golgi Trafficking via RAB1B Inactivation and Promotes Oncogenic Programs in Breast Cancer. [PDF]
Adv Sci (Weinh)TBC1D22B, a Golgi‐localized RabGAP linked to poor prognosis in breast cancer, inhibits ER‐to‐Golgi transport via RAB1B inactivation. This disrupts secretion, drives oncogenic transcriptional reprogramming, and promotes tumor growth. These findings indicate that TBC1D22B connects membrane trafficking to transcriptional control and cancer progression ...
Martino F +16 more
europepmc +2 more sources
Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation [PDF]
, 2015 Rab GTPases control membrane identity, fusion, and transport by interaction with effector proteins. Effectors that influence the activation/inactivation cycle of their own or other Rabs contribute to the timely conversion of Rab identities.
Buser, Dominik P. +3 more
core +1 more source
Rabs, Rips, FIPs, and Endocytic Membrane Traffic
The Scientific World Journal, 2003 Rab GTPases, proteins belonging to the Ras-like small GTP-binding protein superfamily, have emerged as master regulators of cellular membrane transport.
Rytis Prekeris
doaj +1 more source
Human Golgi phosphoprotein 3 is an effector of RAB1A and RAB1B.
PLoS ONE, 2020 Golgi phosphoprotein 3 (GOLPH3) is a peripheral membrane protein localized at the trans-Golgi network that is also distributed in a large cytosolic pool.
Viviana A Cavieres +7 more
doaj +1 more source
Regulation of polarised growth in fungi [PDF]
, 2008 Polarised growth in fungi occurs through the delivery of secretory vesicles along tracks formed by cytoskeletal elements to specific sites on the cell surface where they dock with a multiprotein structure called the exocyst before fusing with the ...
Adamo +112 more
core +1 more source
Thermodynamic bounds on the ultra- and infra-affinity of Hsp70 for its substrates [PDF]
, 2017 The 70 kDa Heat Shock Proteins Hsp70 have several essential functions in living systems, such as protecting cells against protein aggregation, assisting protein folding, remodeling protein complexes and driving the translocation into organelles.
Hartich, David +3 more
core +2 more sources