The rab3A-22A chimera prevents sperm exocytosis by stabilizing open fusion pores [PDF]
, 2016 At the final stage of exocytotis, a fusion pore opens between the plasma and a secretory vesicle membranes; typically, when the pore dilates the vesicle releases its cargo.
Bustos, Matias Alberto +5 more
core +1 more source
RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. [PDF]
PLoS Genetics, 2012 A significant percentage of young men are infertile and, for the majority, the underlying cause remains unknown. Male infertility is, however, frequently associated with defective sperm motility, wherein the sperm tail is a modified flagella/cilia ...
Jennifer C Y Lo +13 more
doaj +1 more source
HUNK Phosphorylates Rubicon to Support Autophagy [PDF]
, 2019 Background: Autophagy is a catabolic cellular recycling pathway that is essential for maintaining intracellular homeostasis. Autophagosome formation is achieved via the coordination of the Beclin-1 protein complex.
Abt, Melissa +5 more
core +1 more source
Characterization of the Populus Rab family genes and the function of PtRabE1b in salt tolerance
BMC Plant Biology, 2018 Background Rab proteins form the largest family of the Ras superfamily of small GTP-binding proteins and regulate intracellular trafficking pathways. However, the function of the Rab proteins in woody species is still an open question.
Jin Zhang +8 more
doaj +1 more source
Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. [PDF]
, 2012 Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes.
Cox, Sarah +4 more
core +1 more source
The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions. [PDF]
, 2015 Given their obligate intracellular lifestyle, Chlamydia trachomatis ensure their access to multiple host sources of essential lipids by interfering vesicular transport.
Capmany, Anahi +7 more
core +1 more source
Apical transport of influenza A virus ribonucleoprotein requires Rab11-positive recycling endosome.
PLoS ONE, 2011 Influenza A virus RNA genome exists as eight-segmented ribonucleoprotein complexes containing viral RNA polymerase and nucleoprotein (vRNPs). Packaging of vRNPs and virus budding take place at the apical plasma membrane (APM).
Fumitaka Momose +6 more
doaj +1 more source
The Ras protein superfamily: Evolutionary tree and role of conserved amino acids [PDF]
, 2012 The Ras superfamily is a fascinating example of functional diversification in the context of a preserved structural framework and a prototypic GTP binding site.
Fuentes, Gloria +3 more
core +1 more source
Location of light-repressible, small GTP-binding protein of the YPT/rab family in the growing zone of etiolated pea stems. [PDF]
Proceedings of the National Academy of Sciences, 1995 YPT/rab proteins are ras-like small GTP-binding proteins that serve as key regulators of vesicular transport. The mRNA levels of two YPT/rab genes in pea plants are repressed by light, with the process mediated by phytochrome. Here, we examined the mRNA expression and the location of the two proteins, pra2- and pra3-encoded proteins, using monoclonal ...
Y, Nagano +4 more
openaire +2 more sources
TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells [PDF]
, 2014 Rab11a is a key modulator of vesicular trafficking processes, but there is limited information about the guanine nucleotide-exchange factors and GTPase-activating proteins (GAPs) that regulate its GTP-GDP cycle. We observed that in the presence of Mg(2+)
Apodaca, Gerard +9 more
core +2 more sources