Results 41 to 50 of about 112,284 (228)
Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin [PDF]
Journal of Cell Science, 2016 A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β-catenin translocation to the nucleus. In this study, we investigated the mechanism of Rac1 stimulation by Wnt. Upregulation of Rac1 activity by Wnt3a temporally correlated with enhanced p120-catenin binding to Rac1 and Vav2. Vav2 and Rac1
Valls, Gabriela +8 more
openaire +4 more sources
Regulation of cell protrusions by small GTPases during fusion of the neural folds
eLife, 2016 Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida.
Ana Rolo +8 more
doaj +1 more source
CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors
Communicative & Integrative Biology, 2019 Fam49 proteins, now referred to as CYRI (CYFIP-related Rac Interactor), are evolutionarily conserved across many phyla. Their closest relative by amino acid sequence is CYFIP, as both proteins contain a domain of unknown function DUF1394.
Jamie A. Whitelaw +5 more
doaj +1 more source
Nucleophosmin1 is a negative regulator of the small GTPase Rac1. [PDF]
PLoS ONE, 2013 The Rac1 GTPase is a critical regulator of cytoskeletal dynamics and controls many biological processes, such as cell migration, cell-cell contacts, cellular growth and cell division.
Younes Zoughlami +3 more
doaj +1 more source
Frontiers in Physiology, 2021 Ras-related C3 botulinum toxin substrate 1 (RAC1) activation plays a vital role in diabetic nephropathy (DN), but the exact mechanism remains unclear.
Changjiang Ying +7 more
doaj +1 more source
Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines [PDF]
, 2017 Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia.
Cabrera, Maia Diana Eliana +7 more
core +2 more sources
Ezrin-related phosphoinositide pathway modifies RhoA and Rac1 in human osteosarcoma cell lines [PDF]
, 2015 Selected Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes occupy the convergence point of the broad range of pathways that promote Rho and Ras GTPase mediated signalling, which also regulate the activation of ezrin, a member of the ezrin ...
DELLA ROCCA, Carlo +2 more
core +1 more source
Characterization and functional analysis of the calmodulin-binding domain of Rac1 GTPase. [PDF]
PLoS ONE, 2012 Rac1, a member of the Rho family of small GTPases, has been shown to promote formation of lamellipodia at the leading edge of motile cells and affect cell migration.
Bing Xu +2 more
doaj +1 more source
Rac1 Deletion Causes Thymic Atrophy
PLoS ONE, 2011 The thymic stroma supports T lymphocyte development and consists of an epithelium maintained by thymic epithelial progenitors. The molecular pathways that govern epithelial homeostasis are poorly understood. Here we demonstrate that deletion of Rac1 in Keratin 5/Keratin 14 expressing embryonic and adult thymic epithelial cells leads to loss of the ...
Hunziker, Lukas +14 more
openaire +6 more sources
Myelination: all about Rac n roll. [PDF]
, 2007 During the development of the peripheral nervous system, Schwann cells select individual axons from a nerve bundle and establish a one-to-one relationship through a process termed radial sorting. Recent findings identify the Rho family GTPase Rac1 as the
Chan, Jonah
core +2 more sources