Results 41 to 50 of about 131,005 (322)

RhoB regulates cell migration through altered focal adhesion dynamics [PDF]

Open Biology, 2012
The Rho GTPase RhoB has been shown to affect cell migration, but how it does this is not clear. Here we show that cells depleted of RhoB by RNAi are rounded and have defects in Rac-mediated spreading and lamellipodium extension, although they have active
Francisco M. Vega, Audrey Colomba, Nicolas Reymond, Mairian Thomas, Anne J. Ridley   +4 more
doaj   +1 more source

Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib. [PDF]

, 2016
Signaling via the B cell receptor (BCR) plays an important role in the pathogenesis and progression of chronic lymphocytic leukemia (CLL). This is underscored by the clinical effectiveness of ibrutinib, an inhibitor of Bruton's tyrosine kinase (BTK) that
Chen, L, Chen, Y, Choi, MY, Cui, B, Kipps, TJ, Rassenti, LZ, Widhopf Ii, GF, Wu, Christina, Yu, J, Zhang, L   +9 more
core   +1 more source

Statins Disrupt Macrophage Rac1 Regulation Leading to Increased Atherosclerotic Plaque Calcification

Arteriosclerosis, Thrombosis and Vascular Biology, 2020
Supplemental Digital Content is available in the text. Objective: Calcification of atherosclerotic plaque is traditionally associated with increased cardiovascular event risk; however, recent studies have found increased calcium density to be associated ...
A. Healy, Joshua Berus, Jared L. Christensen, Cadence Lee, C. Mantsounga, Willie Dong, Jerome P. Watts, M. Assali, Nicolle M. Ceneri, R. Nilson, Jade Neverson, Wen‐Chih Wu, G. Choudhary, A. Morrison   +13 more
semanticscholar   +1 more source

Rac1 and RhoA: Networks, loops and bistability [PDF]

Small GTPases, 2018
Cell migration requires a precise temporal and spatial coordination of several processes which allow the cell to efficiently move. The extension and retraction of membrane protrusion, as well as adhesion are controlled by the Rho-family small GTPases. Two members of the family, Rac1 and RhoA, can show opposite behaviors and spatial localisations, with ...
L. Nguyen, B. Kholodenko, A. von Kriegsheim   +2 more
semanticscholar   +4 more sources

FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells

Cell Structure and Function, 2023
Invadopodia are protrusive structures that mediate the extracellular matrix (ECM) degradation required for tumor invasion and metastasis. Rho small GTPases regulate invadopodia formation, but the molecular mechanisms of how Rho small GTPase activities ...
Koji Saito, Sakino Ozawa, Yosuke Chiba, Ruri Takahashi, Ryoya Ogomori, Kojiro Mukai, Tomohiko Taguchi, Hiroyasu Hatakeyama, Yasutaka Ohta   +8 more
doaj   +1 more source

A novel Rac1-GSPT1 signaling pathway controls astrogliosis following central nervous system injury [PDF]

, 2016
Astrogliosis (i.e. glial scar), which is comprised primarily of proliferated astrocytes at the lesion site and migrated astrocytes from neighboring regions, is one of the key reactions in determining outcomes after CNS injury.
Aiba, Atsu, Gutmann, David H, Hamada, Takeshi, Ishii, Taiji, Kohmura, Eiji, Kohta, Masaaki, Kondoh, Takeshi, Kuboyama, Tomoharu, Saito, Naoaki, Shigyo, Michiko, Tohda, Chihiro, Uebi, Tatsuya, Ueyama, Takehiko   +12 more
core   +2 more sources

Rac1 regulates platelet microparticles formation and rheumatoid arthritis deterioration

Platelets, 2020
Platelets play important roles in blood clotting, hemostasis and wound repair, while more and more research show that platelets also have significant contributions in the process of inflammation.
Xue Chen
doaj   +1 more source

Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells [PDF]

, 2014
Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases signaling, in particular Rac1 activity,
Alonso, Daniel Fernando, Cardama, Georgina Alexandra, Ciarlantini, Matias Sebastián, Comin, Maria Julieta, Gandolfi Donadío, Lucía, Gomez, Daniel Eduardo, González, Nazareno, Lorenzano Menna, Pablo   +7 more
core   +2 more sources

Rap1-Rac1 Circuits Potentiate Platelet Activation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
Objective— The goal of this study was to investigate the potential crosstalk between Rap1 and Rac1, 2 small GTPases central to platelet activation, particularly downstream of the collagen receptor GPVI. Methods and Results— We compared the activation response of platelets with ...
Stefanini, Lucia, Boulaftali, Yacine, Ouellette, Timothy D., Holinstat, Michael, Désiré, Laurent, Leblond, Bertrand, Andre, Patrick, Conley, Pamela B., Bergmeier, Wolfgang   +8 more
openaire   +2 more sources

GEFs: Dual regulation of Rac1 signaling [PDF]

Small GTPases, 2016
GEFs play a critical role in regulating Rac1 signaling. They serve as signaling nodes converting upstream signals into downstream Rac1-driven cellular responses. Through associating with membrane-bound Rac1, GEFs facilitate the exchange of GDP for GTP, thereby activating Rac1.
Hadir Marei1, Malliri, Angeliki
openaire   +2 more sources