Results 31 to 40 of about 83,967 (245)

RhoB regulates cell migration through altered focal adhesion dynamics [PDF]

Open Biology, 2012
The Rho GTPase RhoB has been shown to affect cell migration, but how it does this is not clear. Here we show that cells depleted of RhoB by RNAi are rounded and have defects in Rac-mediated spreading and lamellipodium extension, although they have active
Francisco M. Vega, Audrey Colomba, Nicolas Reymond, Mairian Thomas, Anne J. Ridley   +4 more
doaj   +1 more source

FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells

Cell Structure and Function, 2023
Invadopodia are protrusive structures that mediate the extracellular matrix (ECM) degradation required for tumor invasion and metastasis. Rho small GTPases regulate invadopodia formation, but the molecular mechanisms of how Rho small GTPase activities ...
Koji Saito, Sakino Ozawa, Yosuke Chiba, Ruri Takahashi, Ryoya Ogomori, Kojiro Mukai, Tomohiko Taguchi, Hiroyasu Hatakeyama, Yasutaka Ohta   +8 more
doaj   +1 more source

Rac1 regulates platelet microparticles formation and rheumatoid arthritis deterioration

Platelets, 2020
Platelets play important roles in blood clotting, hemostasis and wound repair, while more and more research show that platelets also have significant contributions in the process of inflammation.
Xue Chen
doaj   +1 more source

Development of a New and Improved Guanidine-based Rac1 Inhibitor with in Vivo Activity against Non-Small Cell Lung Cancer [PDF]

, 2020
Rac1 (Ras-related C3 botulinum toxin substrate 1), is a member of the family of Rho GTPases involved in the dynamic control of cytoskeleton reorganization and other fundamental cellular functions including growth, motility and survival. Aberrant activity
Martín, M. Dodes Traian, javier a, ramirez, Esteban, J. Fiore, Adrián, Turjanski, Lucas, Defelipe, diana, wetzler, Andrea, Barquero, Lucía, Gandolfi-Donadío, Juan, Bayo, Matias S, Ciarlantini, Guillermo, Mazzolini, Maria Julieta, Comin, Hernan A., Bucci   +12 more
core   +1 more source

Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres [PDF]

Open Biology, 2017
Differentiation of columnar epithelial cells involves a dramatic reorganization of the microtubules (MTs) and centrosomal components into an apico-basal array no longer anchored at the centrosome.
Deborah A. Goldspink, Chris Rookyard, Benjamin J. Tyrrell, Jonathan Gadsby, James Perkins, Elizabeth K. Lund, Niels Galjart, Paul Thomas, Tom Wileman, Mette M. Mogensen   +9 more
doaj   +1 more source

Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1 [PDF]

, 2012
Cell-cell junctions are an integral part of epithelia and are often disrupted in cancer cells during epithelial-to-mesenchymal transition (EMT), which is a main driver of metastatic spread.
Susann Bruche, Machesky Laura M., Braga, VMM, Susann Bruche (175558), Machesky, LM, Vania M M Braga, Dawson, JC, John C Dawson, Heather J. Spence (175559), Machesky, L.M., Bruche Susann, Spence Heather J., Heather J Spence, Bruche, S., Vania M. M. Braga (175563), Braga, VM, John C. Dawson (175556), Braga Vania M. M., Spence, HJ, Spence, H.J., Laura M. Machesky (175567), Braga, V.M.M., Dawson, J.C., Laura M Machesky, Bruche, Susann, Bruche, S, Dawson John C.   +26 more
core   +1 more source

Rac1 and RhoA: Networks, loops and bistability [PDF]

Small GTPases, 2016
Cell migration requires a precise temporal and spatial coordination of several processes which allow the cell to efficiently move. The extension and retraction of membrane protrusion, as well as adhesion are controlled by the Rho-family small GTPases. Two members of the family, Rac1 and RhoA, can show opposite behaviors and spatial localisations, with ...
Nguyen, Lan K., Kholodenko, Boris N., von Kriegsheim, Alex   +2 more
openaire   +3 more sources

Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism [PDF]

, 2012
Around a fifth of melanomas exhibit an activating mutation in the oncogene NRas that confers constitutive signaling to proliferation and promotes tumor initiation.
Larue, Lionel, Sansom, Owen J, Machesky, Laura M., Li, Ang, Mort, R.L., Ma, Y., Mason, S., Ma, Yafeng, Blyth, K., Mort, Richard L., Li, A., Sansom, Owen J., Machesky, L.M., Larue, L., Jin, M., Machesky, Laura M, Jin, Meng, Mort, Richard L, Blyth, Karen, Sansom, O.J., Mason, Susan   +20 more
core   +1 more source

Regulation of cell protrusions by small GTPases during fusion of the neural folds

eLife, 2016
Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida.
Ana Rolo, Dawn Savery, Sarah Escuin, Sandra C de Castro, Hannah EJ Armer, Peter MG Munro, Matteo A Molè, Nicholas DE Greene, Andrew J Copp   +8 more
doaj   +1 more source

The function of Copine 6 in the brain [PDF]

, 2012
The formation of new or the remodeling of pre-existing synapses is thought to provide the cellular correlate of learning and memory processes. In the mammalian forebrain, the postsynaptic site of most excitatory synapses is located on dendritic spines ...
Reinhard, Judith
core   +1 more source