Results 41 to 50 of about 83,967 (245)

CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors

Communicative & Integrative Biology, 2019
Fam49 proteins, now referred to as CYRI (CYFIP-related Rac Interactor), are evolutionarily conserved across many phyla. Their closest relative by amino acid sequence is CYFIP, as both proteins contain a domain of unknown function DUF1394.
Jamie A. Whitelaw, Sergio Lilla, Nikki R. Paul, Loic Fort, Sara Zanivan, Laura M. Machesky   +5 more
doaj   +1 more source

Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy

Frontiers in Physiology, 2021
Ras-related C3 botulinum toxin substrate 1 (RAC1) activation plays a vital role in diabetic nephropathy (DN), but the exact mechanism remains unclear.
Changjiang Ying, Jiao Dai, Gaoxia Fan, Zhongyuan Zhou, Tian Gan, Yusheng Zhang, Yuanjian Song, Xiaoyan Zhou   +7 more
doaj   +1 more source

Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells [PDF]

, 2014
Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases signaling, in particular Rac1 activity,
Ciarlantini, Matias, González, Nazareno, Gandolfi Donadío, Lucía, Cardama, Georgina Alexandra, Gomez, Daniel E., Alonso, Daniel Fernando, Lorenzano Menna, Pablo, Ciarlantini, Matias Sebastián, Comin, Maria Julieta, Gomez, Daniel Eduardo, Alonso, Daniel F., Cardama, Georgina A.   +11 more
core   +1 more source

RAS-Related C3 Botulinum Toxin Substrate 1 Inhibition Attenuates Platelet Chemokine Activation in Diabetes Mellitus [PDF]

Archives of Razi Institute
Diabetes mellitus (DM) is a prevalent cause of platelet (PLT) activation. Inflammation-induced dysregulated PLT function adds to chronic problems. Ras-related C3 botulinum toxin substrate 1 (Rac1), a 21 kDa G-protein, has been shown to modulate many PLT ...
Rundk Hwaiz, helen Jawdat, Tavga Salim, Mohammed Merza, Rafil Al-Rawi   +4 more
doaj   +1 more source

Rac1 GTPase in pancreatic cancer

Aging, 2015
Pancreatic cancer is the fourth leading cause of cancer death in the Western world. It is a disease of insidious progression and high lethality, with a 5 year survival rate of only 6%. In spite of significant advances in pancreatic cancer research, current therapies are ineffective and fail to significantly extend lifespan.
Ying, Yan, Michel M, Ouellette
openaire   +2 more sources

Characterization and functional analysis of the calmodulin-binding domain of Rac1 GTPase. [PDF]

PLoS ONE, 2012
Rac1, a member of the Rho family of small GTPases, has been shown to promote formation of lamellipodia at the leading edge of motile cells and affect cell migration.
Bing Xu, Prashen Chelikani, Rajinder P Bhullar   +2 more
doaj   +1 more source

Lack of RAC1 in macrophages protects against atherosclerosis.

PLoS ONE, 2020
The Rho GTPase RAC1 is an important regulator of cytoskeletal dynamics, but the role of macrophage-specific RAC1 has not been explored during atherogenesis. We analyzed RAC1 expression in human carotid atherosclerotic plaques using immunofluorescence and
Sashidar Bandaru, Chandu Ala, Matias Ekstrand, Murali K Akula, Matteo Pedrelli, Xi Liu, Göran Bergström, Liliana Håversen, Jan Borén, Martin O Bergo, Levent M Akyürek   +10 more
doaj   +3 more sources

Cocaine activates Rac1 to control structural and behavioral plasticity in caudate putamen

Neurobiology of Disease, 2015
Repeated exposure to cocaine was previously found to cause sensitized behavioral responses and structural remodeling on medium spiny neurons of the nucleus accumbens (NAc) and caudate putamen (CPu).
Juan Li, Lei Zhang, Zhenzhong Chen, Minjuan Xie, Lu Huang, Jinhua Xue, Yutong Liu, Nuyun Liu, Fukun Guo, Yi Zheng, Jiming Kong, Lin Zhang, Lu Zhang   +12 more
doaj   +1 more source

Rac1-induced lamellipodia formation is independent of FMNL2.

, 2018
(A) Single MCF10A cells expressing mCherry-PA-Rac1 were globally photoactivated and monitored over time. (B) Quantification of Rac1-induced cell enlargement in indicated cell lines over time (n = 15 (WT), n = 17 (CRISPR con), n = 15 (FMNL2-/-, n = 11 ...
Christian Baarlink (5007614), Hanna Grobe (5007608), Robert Grosse (441122), Katharina Grikscheit (5007617), Andrea Wüstenhagen (5007611)   +4 more
core   +1 more source

Serine-71 phosphorylation of Rac1 modulates downstream signaling. [PDF]

PLoS ONE, 2012
The Rho GTPases Rac1 and Cdc42 regulate a variety of cellular functions by signaling to different signal pathways. It is believed that the presence of a specific effector at the location of GTPase activation determines the route of downstream signaling ...
Janett Schwarz, Julia Proff, Anika Hävemeier, Markus Ladwein, Klemens Rottner, Britta Barlag, Andreas Pich, Helma Tatge, Ingo Just, Ralf Gerhard   +9 more
doaj   +1 more source