Results 11 to 20 of about 83,967 (245)

Compartmentalisation of RAC1 Signalling [PDF]

Current Opinion in Cell Biology, 2018
RAC1 signalling has been implicated in a variety of dynamic cell biological processes that are orchestrated through regulated localisation and activation of RAC1.
Angeliki Malliri, Aishwarya Payapilly, Malliri, Angeliki, Malliri, Angeliki; id_orcid, Boben Payapilly, Aishwarya   +4 more
core   +6 more sources

Rac1 in human diseases:The therapeutic potential of targeting Rac1 signaling regulatory mechanisms [PDF]

Small GTPases, 2016
Abnormal Rac1 signaling is linked to a number of debilitating human diseases,including, cancer, cardiovascular diseases and neurodegenerative disorders.
Malliri, Angeliki, Malliri, Angeliki; id_orcid, Marei, Hadir   +2 more
core   +5 more sources

Rac1 Deletion Causes Thymic Atrophy [PDF]

PLoS ONE, 2011
The thymic stroma supports T lymphocyte development and consists of an epithelium maintained by thymic epithelial progenitors. The molecular pathways that govern epithelial homeostasis are poorly understood.
Glogauer Michael, Wright, Nick A, Geoff Laurent, Watt, FM, Janes, Sam M., Kristin M Braun, Emma Nye, Potton, E, Braun, Kristin M., Fiona M. Watt, Janes, Sam M, Katrina McNulty, Butler, Colin, Potton Elspeth, Glogauer, Michael, Wright, NA, Colin Butler, Benitah, Salvador Aznar, Potton, Elspeth, Aznar Benitah Salvador, Boyd, Richard, Jensen, K, Richard Boyd, Braun, Kristin M, Salvador Aznar Benitah, Butler Colin, Sam M Janes, Hunziker, L, Laurent, G, McNulty, Katrina, Elspeth Potton, Janes Sam M., Watt, Fiona M; id_orcid, Boyd, R, Nick A Wright, Kristin M. Braun, Nye, Emma, Laurent Geoff, Michael Glogauer, Wright Nick A., Nye, E, Butler, C, Braun, Kristin, Jensen Kim, Nye Emma, Wright, Nick A., McNulty, Ksatrina, Lukas Hunziker, Glogauer, M, McNulty Katrina, Sam M. Janes, Braun, KM, Laurent, Geoff, Hunziker Lukas, Watt, Fiona, Kim Jensen, Benitah, SA, Nick A. Wright, Watt Fiona M., McNulty, K, Boyd Richard, Fiona M Watt, Wright, Nick, Braun Kristin M., Watt, Fiona M., Jensen, Kim, Janes, SM, Hunziker, Lukas, Aznar Benitah, Salvador, Benitah, Salvador, Janes, Sam   +70 more
core   +8 more sources

Rac1 meets ubiquitin: New insights in Rac1 signalling [PDF]

, 2011
Het cytoskelet bestaat uit eiwitketens (polymeren), waarvan de lengte fluctueren. Het functioneert onder andere als ‘wegennet’ en reguleert het transport van eiwitten naar specifieke plaatsen binnen de cel.
Nethe, M.
core   +23 more sources

GEFs:Dual regulation of Rac1 signaling [PDF]

Small GTPases, 2016
GEFs play a critical role in regulating Rac1 signaling. They serve as signaling nodes converting upstream signals into downstream Rac1-driven cellular responses.
Hadir Marei1, Malliri, Angeliki, Malliri, Angeliki; id_orcid   +2 more
core   +4 more sources

Redox Regulation of Rac1 [PDF]

, 2013
Rac1 is a ubiquitous 21 kD guanine nucleotide binding protein that is a member of a large superfamily of GTPases, which plays a central role in fundamental cell processes, including cell motility and morphology, gene expression, cell cycle control and ...
Mitchell, Lauren Elizabeth
core   +2 more sources

Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin [PDF]

Journal of Cell Science, 2012
A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β-catenin translocation to the nucleus. In this study, we investigated the mechanism of Rac1 stimulation by Wnt.
García de Herreros, Antonio, Duñach, Mireia, Valle Pérez, Beatriz del, Valls, Gabriela, Miller, Rachel K., McCrea, Pierre D., Codina, Montserrat, Vinyoles, Meritxell, Caelles Franch, Carme   +8 more
core   +6 more sources

Rac1 regulates pancreatic islet morphogenesis. [PDF]

BMC Developmental Biology, 2009
BACKGROUND: Pancreatic islets of Langerhans originate from endocrine progenitors within the pancreatic ductal epithelium. Concomitant with differentiation of these progenitors into hormone-producing cells such cells delaminate, aggregate and migrate away
Greiner, Thomas, Ståhlberg, Anders,, Semb, Henrik, Semb, Henrik,, Lund University., Ståhlberg, Anders, Greiner, Thomas U.,, Kesavan, Gokul,, Kesavan, Gokul, Greiner, Thomas,   +9 more
core   +4 more sources

Mechanistic Differences of Activation of Rac1^P29S and Rac1^A159V [PDF]

The Journal of Physical Chemistry B, 2021
Rac1 is a small GTPase that plays key roles in actin reorganization, cell motility, and cell survival/growth as well as in various cancer types and neurodegenerative diseases. Similar to other Ras superfamily GTPases, Rac1 switches between active GTP-bound and inactive GDP-bound states.
Simge Senyuz, Hyunbum Jang, Ruth Nussinov, Ozlem Keskin, Attila Gursoy   +4 more
openaire   +3 more sources

Rac1 gets fattier [PDF]

The EMBO Journal, 2012
Since its description more than two decades ago as a substrate for botulinum C3 exoenzyme ([Didsbury et al , 1989][1]), Rac1 has been one of the most studied small GTPases of the Ras superfamily. Interest in Rac1 exploded in 1992 when Ridley and Hall published their seminal work showing that Rac1 regulates the actin cytoskeleton to promote lamellipodia
Frederick D, Tsai, Mark R, Philips
openaire   +2 more sources