Results 111 to 120 of about 746 (128)
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Methods in Enzymology, 2023
Racemases and epimerases have attracted much interest because of their astonishing ability to catalyze the rapid α-deprotonation of carbon acid substrates with high pKa values (∼13-30) leading to the formation of d-amino acids or various carbohydrate diastereomers that serve important roles in both normal physiology and pathology.
Stephen L, Bearne, Joshua A, Hayden
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Racemases and epimerases have attracted much interest because of their astonishing ability to catalyze the rapid α-deprotonation of carbon acid substrates with high pKa values (∼13-30) leading to the formation of d-amino acids or various carbohydrate diastereomers that serve important roles in both normal physiology and pathology.
Stephen L, Bearne, Joshua A, Hayden
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Chemistry – A European Journal, 2020
AbstractUnlike most enzymes, which exhibit stereospecific substrate binding, racemases and epimerases bind and catalyze the reversible interconversion of enantiomeric and epimeric pairs of substrates. Over the past 15 years, a growing number of racemase and epimerase structures have been solved, furnishing insights into the nature of chiral recognition
Stephen L Bearne
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AbstractUnlike most enzymes, which exhibit stereospecific substrate binding, racemases and epimerases bind and catalyze the reversible interconversion of enantiomeric and epimeric pairs of substrates. Over the past 15 years, a growing number of racemase and epimerase structures have been solved, furnishing insights into the nature of chiral recognition
Stephen L Bearne
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Methods in Enzymology, 2023
Racemases and epimerases catalyze the inversion of stereochemistry at asymmetric carbon atoms to generate stereoisomers that often play important roles in normal and pathological physiology. Consequently, there is interest in developing inhibitors of these enzymes for drug discovery.
Stephen L Bearne
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Racemases and epimerases catalyze the inversion of stereochemistry at asymmetric carbon atoms to generate stereoisomers that often play important roles in normal and pathological physiology. Consequently, there is interest in developing inhibitors of these enzymes for drug discovery.
Stephen L Bearne
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13 Amino Acid Racemases and Epimerases
The Enzymes, 1972Publisher Summary This chapter describes the assay methods and mechanism of action of amino acid racemases and epimerases. Amino acid racemases catalyze the formation of a racemic mixture from either the D or L form of a free amino acid by equilibrating configuration at the α-carbon.
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Biochemical and Biophysical Research Communications, 1994
Profile analysis showed the title enzymes to be homologous with the aminotransferases. 1-Aminocyclopropane-1-carboxylate synthase is closely related to subgroup I of aminotransferases which includes aspartate, alanine, histidinol-phosphate, tyrosine and phenylalanine aminotransferase.
P K, Mehta, P, Christen
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Profile analysis showed the title enzymes to be homologous with the aminotransferases. 1-Aminocyclopropane-1-carboxylate synthase is closely related to subgroup I of aminotransferases which includes aspartate, alanine, histidinol-phosphate, tyrosine and phenylalanine aminotransferase.
P K, Mehta, P, Christen
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Proteins and peptides produced by the ribosome are initially composed of the 20 proteinogenic amino acids, 19 of which are chiral and have an L-configuration. One class of ribosomally synthesized peptides of interest are called bacteriocins. Bacteriocins are antibacterial peptides and exert their effects through a wide variety of mechanisms.
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Alginate modifying enzymes: An updated comprehensive review of the mannuronan C5-epimerases
Algal Research, 2023Benwei Zhu
exaly
Exploiting Mannuronan C-5 Epimerases in Commercial Alginate Production
Marine Drugs, 2020Anne Tøndervik +2 more
exaly