Results 161 to 170 of about 27,541 (198)

Blockade of Tumor TAK1 Induces DNA Damage and Immunogenic cGAS-STING Pathway Activation in Pancreatic Cancer. [PDF]

Gastroenterology
Bansod SP, Hung-Po Chen T, Somani VK, Li L, Geng Y, Wang Y, Bulle A, Modekurty S, Knolhoff BL, Fields RC, Ruzinova MB, DeNardo DG, Lim KH.   +12 more
europepmc   +1 more source

Correction to 'Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

An immuno-chemotherapeutic bone scaffold for tumor eradication and bone regeneration in drug-resistant osteosarcoma. [PDF]

Bioact Mater
Yan Z, He Y, Zeng J, He T, Xu D, Wu X, Zhou H, Tan W, Zang X, Deng Y.   +9 more
europepmc   +1 more source

The role of homologous recombination in human retrovirus-associated diseases. [PDF]

Virus Genes
Akbarin MM, Farjami Z, Acevedo-Jiménez GE, Murillo CR, González-Fernández VD, de María Ávila-De la Vega L, Álvarez HR.   +6 more
europepmc   +1 more source

RAD51: Beyond the break

Seminars in Cell and Developmental Biology, 2021
As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become increasingly clear.
Fumiko Esashi
exaly   +3 more sources

A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling [PDF]

Molecular Cell, 2016
Central to homologous recombination in eukaryotes is the RAD51 recombinase, which forms helical nucleoprotein filaments on single-stranded DNA (ssDNA) and catalyzes strand invasion with homologous duplex DNA. Various regulatory proteins assist this reaction including the RAD51 paralogs.
Martin R G Taylor, Lucy M Collinson, Eric C Greene   +2 more
exaly   +3 more sources

Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2 [PDF]

EMBO Journal, 2003
To clarify RAD51 interactions controlling homologous recombination, we report here the crystal structure of the full-length RAD51 homolog from Pyrococcus furiosus. The structure reveals how RAD51 proteins assemble into inactive heptameric rings and active DNA-bound filaments matching three-dimensional electron microscopy reconstructions.
David S Shin, Luca Pellegrini, Douglas S Daniels   +2 more
exaly   +4 more sources

Swi5–Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance In DNA homologous recombination, recombinase-coated single-stranded DNA filament formation is the first committed step and is subject to tight regulation. Stabilization of nucleoprotein filament by accessory proteins can be achieved by enhancing filament formation, reducing filament disassembly, or both. However, the mechanism of
Chih-Hao Lu, Hsin-Yi Yeh, Guan-Chin Su   +2 more
exaly   +3 more sources

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Interaction of Rad51 with ATP and Mg²⁺ Induces a Conformational Change in Rad51

Biochemistry, 1998
The presumptive first step in the Rad51-promoted formation of joint molecules is binding of the protein to ssDNA in the presence of ATP and Mg2+. In this paper, we report that Rad51's ability to bind DNA is rapidly inactivated when incubated at 30-37 degrees C but is stabilized by the presence of ATP and Mg2+. Although unable to promote binding to DNA,
E A, Namsaraev, P, Berg
openaire   +2 more sources