Results 161 to 170 of about 27,662 (214)

Differential sensitivity of MCPH1- and BRCA2-deficient cancer cells to PARP-1 inhibition. [PDF]

PLoS One
Chapman IG, Wu X, Veuger S, Jowsey PA.
europepmc   +1 more source

Epacadostat and Olaparib Synergistically Inhibit the Growth of BRCA-Proficient Triple-Negative Breast Cancer by Suppressing the Expression of BRCA1 and RAD51. [PDF]

Molecules
Huang L, Yang Y, Duan D, Dai L, Zhai B, Qian B.   +5 more
europepmc   +1 more source

TONSL Promotes Hepatocellular Carcinoma Progression by Inhibiting Apoptosis Through Homologous Recombination Repair. [PDF]

Cancer Sci
Tsujimoto A, Otsu H, Ofuchi T, Ikehara T, Hirose K, Shibuta S, Omachi K, Takahashi Y, Ono Y, Higuchi S, Tatsumi T, Hosoda K, Hu Q, Yonemura Y, Masuda T, Sho M, Mimori K.   +16 more
europepmc   +1 more source

The DNA helicase HELQ promotes replication fork reversal in coordination with BRCA2- and FANCD2-mediated repair pathways. [PDF]

Nucleic Acids Res
Dunbayev Y, Chen YJ, Sassi L, Lee EA, Ra JS, Choi M, Mukherjee A, Vasquez KM, Costanzo V, Chi P, Takata KI.   +10 more
europepmc   +1 more source

PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: implications for the interplay between human DNA damage tolerance pathways. [PDF]

Nucleic Acids Res
Norris JL, Rogers LO, Young G, Pytko KG, Dannenberg RL, Perreault S, Kaushik V, Antony E, Hedglin M.   +8 more
europepmc   +1 more source

Targeting RAD51-BRCA2 Interaction to Enhance Synthetic Lethality with Olaparib in Pancreatic Cancer: Development of a Novel Phenyl Furan-Quinoline-Carboxylic Acid Series. [PDF]

ACS Med Chem Lett
Ferrandi G, Bagnolini G, Poppi L, Masi M, Previtali V, Andonaia A, Varignani G, Veronesi M, De Franco F, Falchi F, Di Stefano G, Girotto S, Roberti M, Cavalli A.   +13 more
europepmc   +1 more source

From mutation to treatment: The dual role of BRCA1 and BRCA2 in gynecological malignancy development and management a systematic review. [PDF]

Biochem Biophys Rep
Georgy DM, Sedeek HN, Abaza NE, Eldeeb SEK, Khamis SM, Elgamil MR, Magar RW.   +6 more
europepmc   +1 more source

The human RAD52 complex undergoes phase separation and facilitates bundling and end-to-end tethering of RAD51 presynaptic filaments. [PDF]

Nucleic Acids Res
Alshareedah I, Pangeni S, Dewan PA, Honda M, Liao TW, Spies M, Ha T.   +6 more
europepmc   +1 more source

BET inhibition disrupts the FOXM1-MYC axis to induce BRCAness and enhance PARP inhibitor response. [PDF]

NPJ Precis Oncol
Fang P, Saunders A, Minn K, Chua KJ, Brooks RA, Bakke D, Leiserowitz GS, Johnson N, Wang S, Chien J.   +9 more
europepmc   +1 more source

Cruciform-forming AT/TA repeats are acted upon by structure-selective endonucleases and Rad51 prior to repositioning to the nuclear periphery for repair. [PDF]

Nucleic Acids Res
Boer JL, Crippen SM, Kim AJ, Kramer DN, Theulot B, Dovrat D, Aharoni A, Smith DJ, Freudenreich CH.   +8 more
europepmc   +1 more source