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Crystal structure of a Rad51 filament
Nature Structural & Molecular Biology, 2004Rad51, the major eukaryotic homologous recombinase, is important for the repair of DNA damage and the maintenance of genomic diversity and stability. The active form of this DNA-dependent ATPase is a helical filament within which the search for homology and strand exchange occurs.
Adam B, Conway +6 more
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RAD51 Paralogs and RAD51 Paralog Complexes BCDX2 and CX3 Interact with BRCA2
Homologous recombination (HR) is an important mechanism for repairing DNA double-strand breaks (DSBs) and preserving genome integrity. Pathogenic mutations in the HR proteins BRCA2 and the RAD51 paralogs predispose individuals to breast, ovarian, pancreatic, and prostate cancer.Jacob G Thrasher +4 more
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INVESTIGAZIONE DELL’INTERAZIONE BRCA2-RAD51
La Chimica e l'IndustriaThis research project aimed at elucidating the BRCA2-RAD51 interaction integrating computational and experimental approaches. Obtained results offer new mechanistic insights into how BRCA2 recruits RAD51 in the cytosol.
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RAD51 Gene Family Structure and Function
Annual Review of Genetics, 2020Braulio Bonilla +2 more
exaly
Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair
Cell, 2021Jonathan Wilde +2 more
exaly
Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein
Molecular Cell, 2023Simon Boulton, Ondřej Belan
exaly