Results 191 to 200 of about 35,752 (235)

Overcoming Resistance in Triple-Negative Breast Cancer: A Translational Perspective on Next-Generation DNA Damage Response Inhibitors and Synthetic Lethality. [PDF]

Molecules
Jończyk J, Czopek A, Kvinta U, Skok A, Zagórska A.   +4 more
europepmc   +1 more source

GNL3 SUMOylation is essential for DNA double-strand break repair by homologous recombination. [PDF]

Nat Commun
Yang Y, Li Y, Dai RS, Chen C, Zientek K, Reddy AP, Xia Z, Sears RC, Sun XX, Dai MS.   +9 more
europepmc   +1 more source

Exploiting DNA damage tolerance for precision oncology. [PDF]

Trends Cancer
Bhat A, Lahane GP, Pandita RK, Bacolla A, Hoden B, Ramos KS, Krishnan S, Sarkar PS, Dhar A, Tainer JA, Pandita TK.   +10 more
europepmc   +1 more source

Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation. [PDF]

Nat Struct Mol Biol
Rawal Y, Kwon Y, Jia L, Ruben EA, Ji JH, Guo L, Stratton CM, Nayak D, Tovar M, Fang Q, Jamalruddin MA, Zhou S, Kuppa S, Syed S, Jasper AM, Katz JN, Rogers CM, Kaur H, Samentar L, Zhao W, Dray E, Zhang F, Stoilova-McPhie S, Taylor AB, Burma S, Rao MK, Libich DS, Hromas R, Mazin AV, Jasin M, Zhou D, Bernstein KA, Greene EC, Wasmuth EV, Sung P, Olsen SK.   +35 more
europepmc   +1 more source

Differential roles of BRCA1 and BRCA2 in the DNA damage response revealed by isogenic V79 mutant cell lines. [PDF]

Mutagenesis
Chailapakul P, Maeda J, Miura T, Kato TA.   +3 more
europepmc   +1 more source

Dynamic chromatin tethering of MDC1 regulates genome stability. [PDF]

Nucleic Acids Res
Heyza JR, Mikhova M, Phillips C, Mehmood S, Perez GI, Broadbent DG, Schmidt JC.   +6 more
europepmc   +1 more source

RAD51: Beyond the break [PDF]

Seminars in Cell and Developmental Biology, 2021
As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become increasingly clear.
Fumiko Esashi
exaly   +4 more sources

Full‐length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

EMBO Journal, 2003
o clarify RAD51 interactions controlling homologous recombination, we report here the crystal structure of the full‐length RAD51 homolog from Pyrococcus furiosus. The structure reveals how RAD51 proteins assemble into inactive heptameric rings and active
Lisa Craig, Tom Blundell, Ashok Venkitaraman   +2 more
exaly   +2 more sources

A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling [PDF]

Molecular Cell, 2016
Central to homologous recombination in eukaryotes is the RAD51 recombinase, which forms helical nucleoprotein filaments on single-stranded DNA (ssDNA) and catalyzes strand invasion with homologous duplex DNA. Various regulatory proteins assist this reaction including the RAD51 paralogs.
Simon Boulton, Lumír Krejčí, Eric C Greene   +2 more
exaly   +3 more sources

RAD-ical New Insights into RAD51 Regulation [PDF]

Genes, 2018
The accurate repair of DNA is critical for genome stability and cancer prevention. DNA double-strand breaks are one of the most toxic lesions; however, they can be repaired using homologous recombination.
Meghan R Sullivan, Kara A. Bernstein
exaly   +2 more sources