Results 171 to 180 of about 27,662 (214)

The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal Cancer. [PDF]

Cancer Discov
Avolio M, Leto SM, Sassi F, Lupo B, Grassi E, Catalano I, Zanella ER, Vurchio V, Cottino F, Tsantoulis PK, Lazzari L, Luraghi P, Ferri M, Galimi F, Berrino E, Bellomo SE, Viviani M, Sogari A, Mauri G, Tosi F, Cruciani F, Sartore-Bianchi A, Siena S, Borghi F, Torri V, Élez E, Tabernero J, Nieva M, Montagut C, Tarazona N, Cervantes A, Tejpar S, Bardelli A, Marchiò C, Marsoni S, Bertotti A, Trusolino L.   +36 more
europepmc   +1 more source

The expanding roles of homologous recombination proteins in genome stability. [PDF]

EMBO J
Sassi L, Martinez Marroquin A, Waked S, Ardizzoia A, Costanzo V.   +4 more
europepmc   +1 more source

Multi-target modulation of the homologous recombination pathway by resveratrol promotes DNA damage repair in POI: integrated network pharmacology, molecular dynamics simulation, and experimental validation. [PDF]

Int J Surg
Yu Z, Peng W, Li M, Li F, Zhang T, Nong Y, Liu C, Liu W, Ding H, Lv X, Wang J, Zhang X, Liu F, Wu H.   +13 more
europepmc   +1 more source

Correction to 'Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

RAD51: Beyond the break

Seminars in Cell and Developmental Biology, 2021
As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become increasingly clear.
Fumiko Esashi
exaly   +3 more sources

A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling [PDF]

Molecular Cell, 2016
Central to homologous recombination in eukaryotes is the RAD51 recombinase, which forms helical nucleoprotein filaments on single-stranded DNA (ssDNA) and catalyzes strand invasion with homologous duplex DNA. Various regulatory proteins assist this reaction including the RAD51 paralogs.
Simon Boulton, Lumír Krejčí, Eric Greene   +2 more
exaly   +3 more sources

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RAD51, genomic stability, and tumorigenesis

Cancer Letters, 2005
Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter recombination pathways to ...
Christine Richardson
exaly   +3 more sources

Swi5–Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance In DNA homologous recombination, recombinase-coated single-stranded DNA filament formation is the first committed step and is subject to tight regulation. Stabilization of nucleoprotein filament by accessory proteins can be achieved by enhancing filament formation, reducing filament disassembly, or both.
Chih-Hao Lu, Kentaro Itô, Peter Chi
exaly   +3 more sources

Interaction of Rad51 with ATP and Mg²⁺ Induces a Conformational Change in Rad51

Biochemistry, 1998
The presumptive first step in the Rad51-promoted formation of joint molecules is binding of the protein to ssDNA in the presence of ATP and Mg2+. In this paper, we report that Rad51's ability to bind DNA is rapidly inactivated when incubated at 30-37 degrees C but is stabilized by the presence of ATP and Mg2+. Although unable to promote binding to DNA,
E A, Namsaraev, P, Berg
openaire   +2 more sources

Identification and characterization of rad51 of Pneumocystis

Gene, 2007
Rad51, a eukaryotic homolog of RecA, is an important protein involved in DNA recombination and repair. We have characterized rad51 of Pneumocystis carinii and Pneumocystis murina. rad51 is a single copy gene that encodes a 1.2 kb mRNA, which contains an open reading frame encoding 343 amino acids.
Geetha, Kutty, Joseph A, Kovacs
openaire   +2 more sources