Results 201 to 210 of about 35,752 (235)

Interaction of Rad51 with ATP and Mg²⁺ Induces a Conformational Change in Rad51

Biochemistry, 1998
The presumptive first step in the Rad51-promoted formation of joint molecules is binding of the protein to ssDNA in the presence of ATP and Mg2+. In this paper, we report that Rad51's ability to bind DNA is rapidly inactivated when incubated at 30-37 degrees C but is stabilized by the presence of ATP and Mg2+. Although unable to promote binding to DNA,
E A, Namsaraev, P, Berg
openaire   +2 more sources

Identification and characterization of rad51 of Pneumocystis

Gene, 2007
Rad51, a eukaryotic homolog of RecA, is an important protein involved in DNA recombination and repair. We have characterized rad51 of Pneumocystis carinii and Pneumocystis murina. rad51 is a single copy gene that encodes a 1.2 kb mRNA, which contains an open reading frame encoding 343 amino acids.
Geetha, Kutty, Joseph A, Kovacs
openaire   +2 more sources

Crystal structure of a Rad51 filament

Nature Structural & Molecular Biology, 2004
Rad51, the major eukaryotic homologous recombinase, is important for the repair of DNA damage and the maintenance of genomic diversity and stability. The active form of this DNA-dependent ATPase is a helical filament within which the search for homology and strand exchange occurs.
Adam B, Conway, Thomas W, Lynch, Ying, Zhang, Gary S, Fortin, Cindy W, Fung, Lorraine S, Symington, Phoebe A, Rice   +6 more
openaire   +2 more sources

RAD51, genomic stability, and tumorigenesis

Cancer Letters, 2005
Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter recombination pathways to ...
openaire   +2 more sources

RAD51 Paralogs and RAD51 Paralog Complexes BCDX2 and CX3 Interact with BRCA2

Homologous recombination (HR) is an important mechanism for repairing DNA double-strand breaks (DSBs) and preserving genome integrity. Pathogenic mutations in the HR proteins BRCA2 and the RAD51 paralogs predispose individuals to breast, ovarian, pancreatic, and prostate cancer.
Jacob G Thrasher, Adeola Augustus G Fagunloye, Fabricio S Justiniano, Kara A Bernstein, Ryan B Jensen   +4 more
openaire   +2 more sources

INVESTIGAZIONE DELL’INTERAZIONE BRCA2-RAD51

La Chimica e l'Industria
This research project aimed at elucidating the BRCA2-RAD51 interaction integrating computational and experimental approaches. Obtained results offer new mechanistic insights into how BRCA2 recruits RAD51 in the cytosol.
openaire   +2 more sources

Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair

Cell, 2021
Jonathan Wilde, Ricardo Del Rosario, Guoping Feng   +2 more
exaly  

Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

Molecular Cell, 2021
Simon Boulton, Artur Kaczmarczyk, Matthew D Newton   +2 more
exaly  

Association of RAD51 with homologous recombination deficiency (HRD) and clinical outcomes in untreated triple-negative breast cancer (TNBC): analysis of the GeparSixto randomized clinical trial

Annals of Oncology, 2021
Violeta Serra, Thomas Karn, P Jank
exaly  

RAD51 Gene Family Structure and Function

Annual Review of Genetics, 2020
Braulio Bonilla, Kara A. Bernstein, Sarah R Hengel   +2 more
exaly