Results 211 to 220 of about 49,012 (231)

Impairment of oxidative metabolism compromises Rad51 recruitment and potentiates PARP inhibitor effectiveness in ovarian cancer. [PDF]

J Exp Clin Cancer Res
Formenti L, Abramo F, Dellavedova G, Dematteis V, Decio A, Grasselli C, Fabbrizio P, Brunelli L, Giavazzi R, Ghilardi C.   +9 more
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Unique hematological presentation of patients with biallelic inactivation of FANCD1/BRCA2. [PDF]

Blood Adv
Niewisch MR, Dierolf M, Herba AB, Thol F, Reimann C, Popp I, Holzhauer S, Behrens YL, Rohde M, Leyh J, Kühnle I, Dilloo D, Stiefel M, Schwarz-Furlan S, Baumann I, Kalb R, Kratz CP.   +16 more
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RAD51, genomic stability, and tumorigenesis

Cancer Letters, 2005
Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter recombination pathways to ...
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RAD51 polymorphisms and breast cancer risk

Molecular Biology Reports, 2012
Breast cancer (BC) is one of the most common causes of death among women, and second in Iran. The objectives of this study were to determine the frequency of RAD51 G/C polymorphism in patients with breast cancer. We evaluated these polymorphisms and effects on the breast cancer risk association in a Iranian sporadic population-based case-control study ...
Mojgan, Hosseini, Massoud, Houshmand, Ahmad, Ebrahimi   +2 more
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Crystal structure of a Rad51 filament

Nature Structural & Molecular Biology, 2004
Rad51, the major eukaryotic homologous recombinase, is important for the repair of DNA damage and the maintenance of genomic diversity and stability. The active form of this DNA-dependent ATPase is a helical filament within which the search for homology and strand exchange occurs.
Adam B, Conway, Thomas W, Lynch, Ying, Zhang, Gary S, Fortin, Cindy W, Fung, Lorraine S, Symington, Phoebe A, Rice   +6 more
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RAD51 Paralogs and RAD51 Paralog Complexes BCDX2 and CX3 Interact with BRCA2

Homologous recombination (HR) is an important mechanism for repairing DNA double-strand breaks (DSBs) and preserving genome integrity. Pathogenic mutations in the HR proteins BRCA2 and the RAD51 paralogs predispose individuals to breast, ovarian, pancreatic, and prostate cancer.
Jacob G Thrasher, Adeola Augustus G Fagunloye, Fabricio S Justiniano, Kara A Bernstein, Ryan B Jensen   +4 more
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Computationally-designed aptamers targeting RAD51-BRCA2 interaction inhibit RAD51 nuclear recruitment

ABSTRACTThe interaction between RAD51 and BRCA2 plays a key role in homologous recombination (HR), a critical DNA repair mechanism essential for the survival of cancer cells. Disrupting this interaction increases the sensitivity of cancer cells to chemotherapeutic agents.
Giulia Milordini, Elsa Zacco, Alexandros Armaos, Francesco Di Palma, Mirco Masi, Martina Gilodi, Jakob Rupert, Laura Broglia, Giulia Varignani, Michele Oneto, Marco Scotto, Roberto Marotta, Stefania Girotto, Andrea Cavalli, Gian Gaetano Tartaglia   +14 more
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