Results 91 to 100 of about 15,150 (235)

Radiation Recall with Anticancer Agents [PDF]

, 2010
Radiation recall is an acute inflammatory reaction confined to previously irradiated areas that can be triggered when chemotherapy agents are administered after radiotherapy.
Jane Hurtig, Howard A. Burris
core   +1 more source

Effect of nanoparticles and x-ray(2-20)MeV on sensitivity enhancement ratio in brain malignant cells

Journal of Kufa-Physics, 2016
The importance of this research is to reduce the number of radiotherapy sessions that are given to patients with brain cancer then result in reducing the side effects of radiation therapy.
Nihad A. Saleh, Talib A. Abdul Wahid
doaj  

Controlling Biogenesis and Engineering of Exosomes to Inhibit Growth and Promote Death in Glioblastoma Multiforme

Brain Sciences
Glioblastoma multiforme (GBM) is characterized by aggressive growth, extensive vascularization, high metabolic malleability, and a striking capacity for therapy resistance.
Srikar Alapati, Swapan K. Ray
doaj   +1 more source

Understanding cisplatin resistance using cellular models [PDF]

, 2007
Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, M, Davey, Mary W., Davey, Mary W, Stordal, B, Britta Stordal, Mary Davey, Stordal, Britta   +6 more
core   +1 more source

Probing the Effects of Retinoblastoma Binding Protein 6 (RBBP6) Knockdown on the Sensitivity of Cisplatin in Cervical Cancer Cells

Cells
Cervical cancer is a major cause of death in women despite the advancement of current treatment modalities. The conventional therapeutic agent, cisplatin (CCDP), is the standard treatment for CC; however, resistance often develops due to the cancer’s ...
Harshini Mehta, Melvin Anyasi Ambele, Ntlotlang Mokgautsi, Pontsho Moela   +3 more
doaj   +1 more source

Uncaging Iridium(III) Complexes for Combined Photodynamic and Photoactivated Chemotherapy

Angewandte Chemie International Edition, EarlyView.
Light‐activatable iridium(III) anticancer prodrugs demonstrate how chalcogen coordination controls photoinduced therapeutic activity. Upon visible‐light irradiation, sulfur‐ and selenium‐based caging ligands undergo distinct oxygen‐dependent photoreactions that trigger ligand release and singlet oxygen generation, enabling combined photoactivated ...
Victoria V. L. Müller, Dominik Moreth, Irene Regeni, Lan Wang, Sylvestre Bonnet, Ulrich Schatzschneider   +5 more
wiley   +1 more source

ALA-RDT in GBM: protocol of the phase I/II dose escalation trial of radiodynamic therapy with 5-Aminolevulinic acid in patients with recurrent glioblastoma

Radiation Oncology
Background Despite improvements in surgical as well as adjuvant therapies over the last decades, the prognosis for patients with glioblastoma remains poor.
Niklas Benedikt Pepper, Hans Theodor Eich, Michael Müther, Michael Oertel, Stephan Rehn, Dorothee Cäcilia Spille, Walter Stummer   +6 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Influence of gamma radiation onto polymeric matrix with papain [PDF]

, 2010
Papain is a proteolytic enzyme that has been widely used as debridement agent for scars and wound healing treatment. However, papain presents low stability, which limits its use to extemporaneous or short shelf-life formulations.
ZULLI, Gislaine, LUGAO, Ademar Benevolo, MATHOR, Monica Beatriz, LOPES, Patricia Santos, VELASCO, Maria Valeria Robles, ROGERO, Sizue Ota, ALCANTARA, Mara Tania Silva   +6 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source