Results 91 to 100 of about 28,129 (278)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Radiation sensitizing effect of COX-2 inhibitor, celecoxib, in HCT-116 colorectal cancer cell line

, 2005
의과학과/석사[한글] 대장암은 서구에서 가장 많은 암종이며 최근 우리 나라에서 크게 증가하고 있는 추세로, 대장암에 대한 화학적 예방에 대한 연구도 활발히 진행되고 있다. 그 중 대표적인 예가 cyclooxygenase (COX)-2와 그의 억제제에 대한 연구이다. COX-2는 여러 암 세포에서 항시적으로 발현되는 것으로 알려져 있으며, 대장암 세포주를 포함한 여러 암세포주에서 COX-2의 선택적 억제제가 발암을 방지하는 효과가 있고, 생체 내외에서
김현석
core  

A Pooled Analysis of Thyroid Cancer Incidence Following Radiotherapy for Childhood Cancer

, 2012
Childhood cancer five-year survival now exceeds 70-80%. Childhood exposure to radiation is a known thyroid carcinogen; however, data are limited for the evaluation of radiation dose-response at high doses, modifiers of the dose-response relationship and ...
de Vathaire, Florent, Shore, Roy, Damber, Lena,, Anderson, Harald, Holmberg, Erik, Adams, M. Jacob, Veiga, Lene H. S., Lubin, Jay H., Inskip, Peter, Hawkins, Michael M, Ron, Elaine, Tucker, Margaret, Lundell, Marie, Pottern, Linda, Lubin, Jay H, Sadetzki, Siegal, Adams, M Jacob, Schneider, Arthur, Johansson, Robert, Johansson, Robert,, Neta, Gila, Sakata, Ritsu, Veiga, Lene H S, Damber, Lena, Bhatti, Parveen, Hawkins, Michael M., Kleinerman, Ruth   +26 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Selective PARP-1 Targeting for Designing Chemo/Radio Sensitizing Agents

, 2006
Poly(ADP-ribose) polymerase-1 (PARP-1) is a central signaling enzyme in a cell nucleus. PARP-1 is a target for the development of radio and chemo sensitizing agents in cancer treatment as well as providing protection from stroke. An SH3 domain and an SH3
Oliveira, Marcos
core  

In vivo interactions between ionizing radiation, inflammation and chemical carcinogens identified by increased DNA damage responses

, 2012
Exposure to ionizing radiation or a variety of chemical agents is known to increase the risk of developing malignancy and many tumors have been linked to inflammatory processes.
Lorimore, S.A., McAllister, K.A., Wright, E.G., Coates, P.J.   +3 more
core   +1 more source

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

BMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song, Binghan Liu, Junjie Liu, Ce Li, Wenqing Man, Xurui Sun, Chang Yuan, Yanjun Wang, Hong Pan, Shuanglian Wang, Zhiming Zheng   +10 more
wiley   +1 more source

University of California Radiation Laboratory Reports UCRL-1743

, 1952
A controversy exists as to the effect of inositol and other lipotropic agents on serum cholesterol levels and atherosclerosis in humans and animals. There is no general agreement that these agents lower serum cholesterol levels or exert an inhibitory ...
Kritchevsky, David, 1920-2006, Pierce, Frank T., Jr.   +1 more
core  

Double Thionation of 4‐Dimethylaminophthalimide Leads to the Development of a Highly Effective Photosensitizer

Chemistry – A European Journal, EarlyView.
We report on the photophysical properties and electronic relaxation mechanisms of 4‐dimethylaminophthalimide (DMAP) and thio‐4‐dimethylaminophthalimide (SDMAP). While DMAP is fluorescent, SDMAP shows negligible fluorescence due to ultrafast intersystem crossing to a long‐lived triplet state that decays in 3.4 ± 0.05 µs.
Chris Acquah, Eric Lee, Sourav Kanti Seth, Reshma Mathew, Rubej R. Khan, Steffen Jockusch, Shudan Yang, Han Xiao, Carlos E. Crespo‐Hernández   +8 more
wiley   +1 more source