Results 81 to 90 of about 15,150 (235)

Bromelain augments ionizing radiation sensitivity in breast cancer cells: A synergistic approach

Journal of Radiation Research and Applied Sciences
Background: Radiation-sensitizing agents, such as Bromelain (pineapple extract) have been shown to significantly impact cancer cell cycle arrest. This study investigates the anticancer properties of Bromelain on MCF-7 breast cancer cell line under both ...
Maryam Jahani Chegeni, Mehdi Salehi Barough, Seyed Pejman Shirmardi, Soheyla Zamanlooye Benisi, Mohammad Reza Babaei, Ashkan Hajinoormohammadi   +5 more
doaj   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Lung cancer after treatment for Hodgkin's disease: focus on radiation effects [PDF]

, 2003
Aspects of radiation-induced lung cancer were evaluated in an international study of Hodgkin's disease. The study population consisted of 227 patients with lung cancer and 455 matched controls. Unique features included dose determinations to the specific
Gilbert, ES, Van, Leeuwen FE, Joensuu, T, Lynch, CF, Andersson, M, Gospodarowicz, M, Holowaty, E, Curtis, RE, Stovall, M, Glimelius, B,   +9 more
core   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

IQGAP3 bridges matrix stiffness with glioma stem cell maintenance and radioresistance by stabilizing SOX2

Nature Communications
Drivers of therapeutic resistance in cancer include evolving tumor cell heterogeneity and the tumor microenvironment (TME). We find that increased matrix stiffness promotes radioresistance in glioblastoma (GBM) and maintains tumor cell hierarchies ...
Po Zhang, Weichi Wu, Tengfei Huang, Xujia Wu, Donghai Wang, Huairui Yuan, Suchet Taori, Fanen Yuan, Frank P. Vendetti, Rui Wang, Tingting Duan, Hailong Mi, Huan Li, Kailin Yang, Daqi Li, Ahmed Habib, Briana C. Prager, Ryan C. Gimple, Pascal O. Zinn, Kalil Abdullah, Christopher Bakkenist, Junran Zhang, Qiulian Wu, Jeremy N. Rich   +23 more
doaj   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Isodose 20 Gy found as a threshold dose for radiation recall dermatitis. [PDF]

, 2019
Radiation recall is a rare phenomenon that can be observed in the field of radiotherapy, months or years after irradiation when a patient is exposed to certain pharmaceutical agents. In this report, we relate a case of radiation recall dermatitis induced
Vozenin, M.C., Ozsahin, M., Bourhis, J., Scher, N., Bouchaab, H.   +4 more
core   +1 more source

Efficacy of insulin-sensitizing agents in nonalcoholic fatty liver disease [PDF]

, 2010
AIM: To investigate the efficacy of insulin-sensitizing agents in nonalcoholic fatty liver disease (NAFLD) patients. Methods This is an open-label, randomized, a single-center study.
Akyildiz M., Batur Y., Akarca U., Cetinkalp S., Yilmaz C., Yilmaz F., Omer Z.   +6 more
core   +1 more source

Targeting mTOR and survivin concurrently potentiates radiation therapy in renal cell carcinoma by suppressing DNA damage repair and amplifying mitotic catastrophe

Journal of Experimental & Clinical Cancer Research
Background Renal cell carcinoma (RCC) was historically considered to be less responsive to radiation therapy (RT) compared to other cancer indications.
Hari K. Rachamala, Vijay S. Madamsetty, Ramcharan S. Angom, Naga M. Nakka, Shamit Kumar Dutta, Enfeng Wang, Debabrata Mukhopadhyay, Krishnendu Pal   +7 more
doaj   +1 more source

Insulin-sensitizing agents in polycystic ovary syndrome. [PDF]

, 2006
Insulin-sensitizing agents have been recently proposed as the therapy of choice for polycystic ovary syndrome (PCOS), since insulin resistance and associated hypermsulinemia are recognized as important pathogenetic factors of the syndrome.
GAMBINERI, ALESSANDRA, PASQUALI, RENATO
core