Results 61 to 70 of about 120,136 (313)
Evaluation of the radiosensitizing potency of chemotherapeutic agents in prostate cancer cells [PDF]
, 2016 PURPOSE: Despite recent advances in the treatment of metastatic prostate cancer, survival rates are low and treatment options are limited to chemotherapy and hormonal therapy.
Mairs, Robert J., Rae, Colin
core +2 more sources
The effect of certain chemical and physical agents on the radiation sensitivity of mouse tumors [PDF]
Cancer, 1961 By a technique employing transplanted mouse tumors, the following observations were made on radiation sensitivity: Intravenous administration of glutathione prior to radiation therapy increased radiation resistance and significantly lowered the tumor remission rate; this effect could be re versed by concomitant testosterone administration; tesiosterone
Modlin, R K, Morris, J M
openaire +2 more sources
BMC Veterinary Research, 2016 BackgroundRadiation therapy is a palliative treatment modality for canine osteosarcoma, with transient improvement in analgesia observed in many cases. However there is room for improvement in outcome for these patients.
F. Mantovani, J. Morrison, A. Mutsaers
semanticscholar +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
BMC Cancer, 2017 Background Agricultural workers may be exposed to potential carcinogens including pesticides, sensitizing agents and solar radiation. Previous studies indicate increased risks of hematopoietic cancers and decreased risks at other sites, possibly due to ...
Linda Kachuri +5 more
doaj +1 more source
Clinical benefit of adding oxaliplatin to standard neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a meta-analysis : Oxaliplatin in neoadjuvant treatment for rectal cancer [PDF]
, 2017 . Background: To evaluate the treatment tolerance and clinical outcomes in patients aged 70 years and older with locally advanced oropharyngeal cancer treated by definitive intensity-modulated radiation therapy (IMRT).
Benevento, Ilaria +6 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Potentiation of peptide receptor radionuclide therapy by the PARP inhibitor olaparib [PDF]
, 2016 Metastases expressing tumor-specific receptors can be targeted and treated by binding of radiolabeled peptides (peptide receptor radionuclide therapy or PRRT).
Beerens, C.E.M.T. (Cecile) +7 more
core +1 more source
cel-mir-237 and its homologue, hsa-miR-125b, modulate the cellular response to ionizing radiation
Oncogene, 2016 Elucidating the mechanisms involved in sensitizing radioresistant tumors to ionizing radiation (IR) treatments while minimizing injury to surrounding normal tissue is an important clinical goal. Due to their sequence-derived specificity and properties as
Chanatip Metheetrairut +4 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source