Results 41 to 50 of about 28,129 (278)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Characterization of Thermally Activated Metalloenediyne Cytotoxicity in Human Melanoma Cells

, 2018
Enediynes are a highly cytotoxic class of compounds. However, metallation of these compounds may modulate their activation, and thus their cytotoxicity.
Karen E. Pollok, Garrett, Joy E., Keller, Eric J., Porter, Meghan, Varie, Meredith, Turchi, John J., Pollok, Karen E., Meghan Porter, Joseph R. Dynlacht, Haiyan Wang, Joy E. Garrett, Meredith Varie, Wang, Haiyan, Eric J. Keller, John J. Turchi, Jeffrey M. Zaleski, Zaleski, Jeffrey M., Dynlacht, Joseph R.   +17 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

In Vitro Radiosensitizing Effects of Temozolomide on U87MG Cell Lines of Human Glioblastoma Multiforme

Iranian Journal of Medical Sciences, 2017
Background: Glioma is the most common primary brain tumor with poor prognosis. Temozolomide (TMZ) has been used with irradiation (IR) to treat gliomas.
Samira Borhani, Hossein Mozdarani, Somayyeh Babalui, Mohsen Bakhshandeh, Hassan Nosrati   +4 more
doaj  

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Cancer risks in a population-based study of 70,570 agricultural workers: results from the Canadian census health and Environment cohort (CanCHEC)

BMC Cancer, 2017
Background Agricultural workers may be exposed to potential carcinogens including pesticides, sensitizing agents and solar radiation. Previous studies indicate increased risks of hematopoietic cancers and decreased risks at other sites, possibly due to ...
Linda Kachuri, M. Anne Harris, Jill S. MacLeod, Michael Tjepkema, Paul A. Peters, Paul A. Demers   +5 more
doaj   +1 more source

A Preliminary Investigation of Radiation-Sensitive Ultrasound Contrast Agents for Photon Dosimetry

Pharmaceuticals
Radiotherapy treatment plans have become highly conformal, posing additional constraints on the accuracy of treatment delivery. Here, we explore the use of radiation-sensitive ultrasound contrast agents (superheated phase-change nanodroplets) as dosimetric radiation sensors.
Carlier, Bram, Heymans, Sophie, Nooijens, Sjoerd, Collado-Lara, Gonzalo, Toumia, Yosra, Delombaerde, Laurence, Paradossi, Gaio, D'hooge, Jan, Van Den Abeele, Koen, Sterpin, Edmond, Himmelreich, Uwe   +10 more
openaire   +7 more sources

Insulin-sensitizing agents and reproductive function in polycystic ovary syndrome patients

, 2008
Purpose of reviewTo review the current reproductive advances in insulin-sensitizing agents for treatment of polycystic ovary syndrome patients.Recent findingsTo date, among insulin-sensitizing drugs, only metformin should be used to improve reproductive ...
Zullo, Fulvio, Palomba, Stefano, Orio, Francesco, Falbo, Angela   +3 more
core   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Enhancement of radiation effectiveness in cervical cancer cells by combining ionizing radiation with hyperthermia and molecular targeting agents

, 2018
Hyperthermia (HT) and molecular targeting agents can be used to enhance the effect of radiotherapy (RT). The purpose of this paper is to evaluate radiation sensitization by HT and different molecular targeting agents (Poly [ADP-ribose] polymerase 1 ...
Stalpers, Lukas J. A., Oei, Arlene L., H. Petra Kok, Lukas J. A. Stalpers, Nicolaas A. P. Franken, Rodermond, Hans M., Przemek M. Krawczyk, Ijff, Marloes, Hans M. Rodermond, van Oorschot, Bregje, Franken, Nicolaas A. P., Marloes IJff, Johannes Crezee, Arlene L. Oei, Bregje Van Oorschot, Crezee, Johannes, Krawczyk, Przemek M., Kok, H. Petra   +17 more
core   +1 more source