Results 21 to 30 of about 15,150 (235)

Targeting Cellular Metabolism With CPI-613 Sensitizes Pancreatic Cancer Cells to Radiation Therapy

Advances in Radiation Oncology, 2023
Purpose: Local tumor progression is a cause of significant morbidity and mortality in patients with pancreatic ductal adenocarcinoma (PDAC) with surgically unresectable disease.
Husain Yar Khan, PhD, Mandana Kamgar, MD, Amro Aboukameel, MS, Sahar Bannoura, MS, Brian Y. Chung, PhD, Yiwei Li, MD, Mohammed Najeeb Al Hallak, MD, Philip A. Philip, MD, PhD, Susan Tsai, MD, Sanjeev Luther, MBA, William A. Hall, MD, Asfar S. Azmi, PhD   +11 more
doaj   +1 more source

Hemodynamic effects of calcium-sensitizing agents [PDF]

, 1995
Over the last few years the development of calcium-sensitizing agents has led to a new approach to the treatment of congestive heart failure (CHF). These novel inotropic agents act directly on the contractile protein systems and correct the reduced ...
Papp Gyula, Végh Ágnes, Udvary Éva, Kaszala Károly   +3 more
core   +1 more source

Selenium-Curcumin-PEG Nanoparticles Radiosensitization for Intensity-Modulated Radiation Therapy of Lung Tumor Cells: In Vitro Synergistic Combination Therapy [PDF]

Journal of Biomedical Physics and Engineering
Background: Lung cancer is a leading cause of cancer-related mortality worldwide, underscoring the need for the development of more effective treatment strategies. Radiotherapy (RT), particularly intensity-modulated radiation therapy (IMRT), has enhanced
Farid Mortazavi, Paria Tamaddon, Ali Ketabi, Hanieh Haghighi, Kiana Khajeheian, Masoud Haghani, Tahereh Mahmoudi, Sadegh Masjoodi, Masoud Negahdary, Naghmeh Sattarahmady   +9 more
doaj   +1 more source

Efficiency Comparison between Radiotherapy Alone And In The Presence of Radio- or Photo- Sensitizers on Viability of DFW and HT29 Cell Lines: From Simulations to Experimental Results [PDF]

Iranian Journal of Medical Physics
Introduction: Radiotherapy (RT) is a conventional cancer treatment which address needs of most cancerous patients. However, toxicity of high X-ray energies increases side effects to the normal tissues.
Farideh Hosseini, Nadia Naghavi, Ameneh Sazgarnia, Atefeh Vejdani Noghreiyan   +3 more
doaj   +1 more source

Does particle radiation have superior radiobiological advantages for prostate cancer cells? A systematic review of in vitro studies

European Journal of Medical Research, 2022
Background Charged particle beams from protons to carbon ions provide many significant physical benefits in radiation therapy. However, preclinical studies of charged particle therapy for prostate cancer are extremely limited.
Tian-Qi Du, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Yanliang Chen, Mingyu Tan, Qian Wang, Xun Wu, Zhiqiang Liu, Shilong Sun, Kehu Yang, Jinhui Tian, Xiaohu Wang   +12 more
doaj   +1 more source

Characterization of Thermally Activated Metalloenediyne Cytotoxicity in Human Melanoma Cells [PDF]

, 2018
Enediynes are a highly cytotoxic class of compounds. However, metallation of these compounds may modulate their activation, and thus their cytotoxicity.
Karen E. Pollok, Garrett, Joy E., Keller, Eric J., Porter, Meghan, Varie, Meredith, Turchi, John J., Pollok, Karen E., Meghan Porter, Joseph R. Dynlacht, Haiyan Wang, Joy E. Garrett, Meredith Varie, Wang, Haiyan, Eric J. Keller, John J. Turchi, Jeffrey M. Zaleski, Zaleski, Jeffrey M., Dynlacht, Joseph R.   +17 more
core   +1 more source

Occupation, exposure to chemicals, sensitizing agents, and risk of multiple myeloma in Sweden [PDF]

, 2008
BACKGROUND: This study sought to identify occupations with high incidence of multiple myeloma and to investigate possible excess risk associated with occupational exposure to chemicals and sensitizing agents in Sweden.
Lope Carvajal, Virginia, Zock, Jan-Paul, Pollan-Santamaria, Marina, Gustavsson, Per, Aragones, Nuria, Plato, Nils, Perez-Gomez, Beatriz, Lopez-Abente, Gonzalo   +7 more
core   +1 more source

Dinitroazetidines Are a Novel Class of Anticancer Agents and Hypoxia-Activated Radiation Sensitizers Developed from Highly Energetic Materials [PDF]

Cancer Research, 2012
Abstract In an effort to develop cancer therapies that maximize cytotoxicity, while minimizing unwanted side effects, we studied a series of novel compounds based on the highly energetic heterocyclic scaffold, dinitroazetidine. In this study, we report the preclinical validation of 1-bromoacetyl-3,3-dinitroazetidine (ABDNAZ), a ...
Shoucheng, Ning, Mark, Bednarski, Bryan, Oronsky, Jan, Scicinski, Gordon, Saul, Susan J, Knox   +5 more
openaire   +3 more sources

Cross-sensitivity to DNA-damaging agents in radiation-sensitive mutants of murine leukemia cells. [PDF]

Journal of Radiation Research, 1986
Two independently isolated radiation-sensitive mutants, M10 and LX830, of mouse L5178Y cells were compared for their sensitivity to various DNA-damaging agents. These two mutants share hypersensitivity to gamma rays, bleomycin, arabinofuranosyl cytosine (Ara-C) and aphidicolin.
K, Sato, A, Ito, N, Hieda-Shiomi, T, Shiomi, H, Hama-Inaba   +4 more
openaire   +2 more sources

The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agent: proposed mechanisms based on a systematic review [PDF]

Journal of Herbmed Pharmacology, 2021
Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds
David Andi Wijaya, Melva Louisa, Heri Wibowo, Aslim Taslim, Tiara Bunga Mayang Permata, Handoko Handoko, Endang Nuryadi, Henry Kodrat, Soehartati Argadikoesoema Gondhowiardjo   +8 more
openaire   +2 more sources