Cancer Nanotechnology, 2022 Background To enhance the performance of radiotherapy, emerging nanoparticles that can professionally enhance X-ray irradiation to destruct cancer cells are extremely necessary.
Mahshid Mohammadian +2 more
doaj +1 more source
Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs. [PDF]
PLoS ONE, 2011 First line chemotherapeutics for brain tumors (malignant gliomas) are alkylating agents such as temozolomide and nimustine. Despite growing knowledge of how these agents work, patients suffering from this malignancy still face a dismal prognosis ...
Steve Quiros +2 more
doaj +1 more source
A Review of Effects of Atorvastatin in Radiotherapy [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Radiation therapy is one of the major subsets of cancer treatments. Normal tissue toxicity and tumor cell resistance are two main obstacles during radiotherapy treatments.
Maryam Alvandi +4 more
doaj +1 more source
The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma [PDF]
, 2018 Background: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM).
Chen, Yi +12 more
core +2 more sources
The potential role and application of PARP inhibitors in cancer treatment [PDF]
, 2009 Background: Since many anti-cancer agents act by inflicting DNA damage on tumour cells, there is increasing interest in the use of inhibitors of DNA repair to increase the cytotoxicity of these agents.
Chalmers, Anthony J
core +2 more sources
Investigating miR-16-5p: The Tumor Suppressor That Influences Cell Cycle Genes in Colorectal Cancer [PDF]
Journal of Biomedical Physics and EngineeringBackground: Colorectal Cancer (CRC) remains a major health challenge, with perturbation in the cell cycle playing a crucial role in its progression. Hsa-miR-16-5p (miR-16-5p) is a crucial tumor suppressor, but its precise role in modulating cell cycle ...
Seyedeh Nasibeh Mousavikia +4 more
doaj +1 more source
Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma [PDF]
, 2018 In this study, our aim is to assess the role played by autophagy and its inhibition in the different PDAC cellular compartments, and its involvement in chemo-resistance using primary human pancreatic cancer-derived cells (PCC) and Cancer Associated ...
Bintz, Jennifer +6 more
core +1 more source
Chrysin and its nanoformulations in cancer therapy: A systematic review of their radiosensitizing, phototherapy-enhancing potentials [PDF]
Journal of HerbMed PharmacologyIntroduction: Chrysin (CHY) is a naturally occurring flavonoid known for its anti-inflammatory and antioxidant properties. This systematic review aims to evaluate the photosensitizing and radiosensitizing effects of CHY and its nanoparticle (NP ...
Mojtaba Saedi Marghmaleki +2 more
doaj +1 more source
The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agent: proposed mechanisms based on a systematic review [PDF]
Journal of Herbmed Pharmacology, 2021 Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds
David Andi Wijaya +8 more
openaire +2 more sources
Valproic Acid-Mediated Reduction of DNA Double-Strand Break Reparation Capacity of Irradiated MCF-7 Cells [PDF]
Iranian Journal of Medical Physics, 2016 Introduction H istone deacetylase inhibitors (HDIs), as radiation sensitizing agents, are considered as a novel class of anti-cancer factors, which are studied in various tumor cell-lines.
Ahmad yarmohamadi +3 more
doaj +1 more source