Results 11 to 20 of about 28,129 (278)

Investigating miR-16-5p: The Tumor Suppressor That Influences Cell Cycle Genes in Colorectal Cancer [PDF]

Journal of Biomedical Physics and Engineering
Background: Colorectal Cancer (CRC) remains a major health challenge, with perturbation in the cell cycle playing a crucial role in its progression. Hsa-miR-16-5p (miR-16-5p) is a crucial tumor suppressor, but its precise role in modulating cell cycle ...
Seyedeh Nasibeh Mousavikia, Maryam M. Matin, Mohammad Taghi Bahreyni-Toossi, Seyed Hamid Aghaee-Bakhtiari, Hosein Azimian   +4 more
doaj   +1 more source

Chrysin and its nanoformulations in cancer therapy: A systematic review of their radiosensitizing, phototherapy-enhancing potentials [PDF]

Journal of HerbMed Pharmacology
Introduction: Chrysin (CHY) is a naturally occurring flavonoid known for its anti-inflammatory and antioxidant properties. This systematic review aims to evaluate the photosensitizing and radiosensitizing effects of CHY and its nanoparticle (NP ...
Mojtaba Saedi Marghmaleki, Mohadeseh Karimian, Elham Raeisi   +2 more
doaj   +1 more source

Valproic Acid-Mediated Reduction of DNA Double-Strand Break Reparation Capacity of Irradiated MCF-7 Cells [PDF]

Iranian Journal of Medical Physics, 2016
Introduction H istone deacetylase inhibitors (HDIs), as  radiation sensitizing agents, are considered as a novel class of anti-cancer factors, which are studied in various tumor cell-lines.
Ahmad yarmohamadi, Jahanbakhsh Asadi, Alireza Khoshbin khoshnazar, Mohammad Mostakhdem Hashemi   +3 more
doaj   +1 more source

Low dose novel PARP-PI3K inhibition via nanoformulation improves colorectal cancer immunoradiotherapy

Materials Today Bio, 2020
Multimodal therapy is often used in oncology to overcome dosing limitations and chemoresistance. Recently, combination immunoradiotherapy has shown great promise in a select subset of patients with colorectal cancer (CRC).
M.R. Landry, A.N. DuRoss, M.J. Neufeld, L. Hahn, G. Sahay, R. Luxenhofer, C. Sun   +6 more
doaj   +1 more source

Targeting Cellular Metabolism With CPI-613 Sensitizes Pancreatic Cancer Cells to Radiation Therapy

Advances in Radiation Oncology, 2023
Purpose: Local tumor progression is a cause of significant morbidity and mortality in patients with pancreatic ductal adenocarcinoma (PDAC) with surgically unresectable disease.
Husain Yar Khan, PhD, Mandana Kamgar, MD, Amro Aboukameel, MS, Sahar Bannoura, MS, Brian Y. Chung, PhD, Yiwei Li, MD, Mohammed Najeeb Al Hallak, MD, Philip A. Philip, MD, PhD, Susan Tsai, MD, Sanjeev Luther, MBA, William A. Hall, MD, Asfar S. Azmi, PhD   +11 more
doaj   +1 more source

The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agent: proposed mechanisms based on a systematic review [PDF]

Journal of Herbmed Pharmacology, 2021
Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds
David Andi Wijaya, Melva Louisa, Heri Wibowo, Aslim Taslim, Tiara Bunga Mayang Permata, Handoko Handoko, Endang Nuryadi, Henry Kodrat, Soehartati Argadikoesoema Gondhowiardjo   +8 more
openaire   +2 more sources

Dinitroazetidines Are a Novel Class of Anticancer Agents and Hypoxia-Activated Radiation Sensitizers Developed from Highly Energetic Materials [PDF]

Cancer Research, 2012
Abstract In an effort to develop cancer therapies that maximize cytotoxicity, while minimizing unwanted side effects, we studied a series of novel compounds based on the highly energetic heterocyclic scaffold, dinitroazetidine. In this study, we report the preclinical validation of 1-bromoacetyl-3,3-dinitroazetidine (ABDNAZ), a ...
Shoucheng, Ning, Mark, Bednarski, Bryan, Oronsky, Jan, Scicinski, Gordon, Saul, Susan J, Knox   +5 more
openaire   +3 more sources

Does particle radiation have superior radiobiological advantages for prostate cancer cells? A systematic review of in vitro studies

European Journal of Medical Research, 2022
Background Charged particle beams from protons to carbon ions provide many significant physical benefits in radiation therapy. However, preclinical studies of charged particle therapy for prostate cancer are extremely limited.
Tian-Qi Du, Ruifeng Liu, Qiuning Zhang, Hongtao Luo, Yanliang Chen, Mingyu Tan, Qian Wang, Xun Wu, Zhiqiang Liu, Shilong Sun, Kehu Yang, Jinhui Tian, Xiaohu Wang   +12 more
doaj   +1 more source

Efficiency Comparison between Radiotherapy Alone And In The Presence of Radio- or Photo- Sensitizers on Viability of DFW and HT29 Cell Lines: From Simulations to Experimental Results [PDF]

Iranian Journal of Medical Physics
Introduction: Radiotherapy (RT) is a conventional cancer treatment which address needs of most cancerous patients. However, toxicity of high X-ray energies increases side effects to the normal tissues.
Farideh Hosseini, Nadia Naghavi, Ameneh Sazgarnia, Atefeh Vejdani Noghreiyan   +3 more
doaj   +1 more source

Cross-sensitivity to DNA-damaging agents in radiation-sensitive mutants of murine leukemia cells. [PDF]

Journal of Radiation Research, 1986
Two independently isolated radiation-sensitive mutants, M10 and LX830, of mouse L5178Y cells were compared for their sensitivity to various DNA-damaging agents. These two mutants share hypersensitivity to gamma rays, bleomycin, arabinofuranosyl cytosine (Ara-C) and aphidicolin.
K, Sato, A, Ito, N, Hieda-Shiomi, T, Shiomi, H, Hama-Inaba   +4 more
openaire   +2 more sources