Results 31 to 40 of about 28,129 (278)

Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair [PDF]

, 2010
As single agents, chemical inhibitors of poly(ADP-ribose) polymerase (PARP) are nontoxic and have clinical efficacy against BRCA1- and BRCA2-deficient tumors.
Atsushi Shibata, Akiko K Shibata (16047095), Lisa Jane Woodbine (16047098), Anthony J. Chalmers, Shibata, Atsushi, Lisa J. Woodbine, Dana A Löser (16047092), Woodbine, Lisa J., Shibata, Akiko K., Atsushi Shibata (445550), Anthony J Chalmers (16046030), Jeggo, Penny A., Chalmers, Anthony J., Dana A. Löser, Penny Jeggo (4461367), Penny A. Jeggo, Löser, Dana A., Akiko K. Shibata   +17 more
core   +2 more sources

Analysis of enhancement at small and large radiation doses for effectiveness of inactivation in cultured cells by combining two agents with radiation

, 2016
To evaluate the enhancement effect of two combined radiation-sensitizing agents in mammalian cells at small doses as compared to large doses using the linear-quadratic (LQ) mathematical model.
Franken, Nicolaas A. P., Crezee, Johannes, Kok, H. Petra, Barendsen, Gerrit W.   +3 more
core   +1 more source

NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin

Scientific Reports, 2017
NEK family kinases are serine/threonine kinases that have been functionally implicated in the regulation of the disjunction of the centrosome, the assembly of the mitotic spindle, the function of the primary cilium and the DNA damage response. NEK1 shows
Talita D. Melo-Hanchuk, Priscila Ferreira Slepicka, Gabriela Vaz Meirelles, Fernanda Luisa Basei, Diogo Ventura Lovato, Daniela Campos Granato, Bianca Alves Pauletti, Romenia Ramos Domingues, Adriana Franco Paes Leme, Alessandra Luiza Pelegrini, Guido Lenz, Stefan Knapp, Jonathan M. Elkins, Jörg Kobarg   +13 more
doaj   +1 more source

Analysis of enhancement at small and large radiation doses for effectiveness of inactivation in cultured cells by combining two agents with radiation

, 2017
Purpose: To evaluate the enhancement effect of two combined radiation-sensitizing agents in mammalian cells at small doses as compared to large doses using the linear-quadratic (LQ) mathematical model.
H. Petra Kok (2941056), Johannes Crezee (2941059), Gerrit W. Barendsen (2941050), Nicolaas A. P. Franken (2941053)   +3 more
core   +1 more source

Responses to the 2017 ‘1 Million Gray Question’: ASTRO membership’s opinions on the most important research question facing radiation oncology

, 2018
At the American Society for Radiation Oncology's (ASTRO's) 2017 annual meeting in San Diego, CA, attendees were asked, “What is the most important research question that needs to be answered in the next 3 to 5 years?” This request was meant to start a ...
Moros, Eduardo G., Beck, Tyler F., Bayouth, John, Mian, Omar, Brock, Kristy K., Dominello, Michael M., Mendonca, Marc S., Carlson, David J., Anscher, Mitchell, Hugo, Geoffrey, Knisely, Jonathan, Yu, James B., Singh, Anurag K., Keen, Judith C.   +13 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hemodynamic effects of calcium-sensitizing agents

, 1995
Over the last few years the development of calcium-sensitizing agents has led to a new approach to the treatment of congestive heart failure (CHF). These novel inotropic agents act directly on the contractile protein systems and correct the reduced ...
Papp Gyula, Végh Ágnes, Udvary Éva, Kaszala Károly   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Overcoming radioresistance in WiDr cells with heavy ion irradiation and radiosensitization by 2-deoxyglucose with photon irradiation

Clinical and Translational Radiation Oncology, 2019
Background and purpose: Radiosensitizers and heavy ion irradiation could improve therapy for female patients with malignant tumors located in the pelvic region through dose reduction.
Felix Christian Hasse, Stefan Alexander Koerber, Elena Sophie Prigge, Jakob Liermann, Magnus von Knebel Doeberitz, Juergen Debus, Florian Sterzing   +6 more
doaj   +1 more source