Insulin-sensitizing agents and reproductive function in polycystic ovary syndrome patients [PDF]
, 2008 Purpose of reviewTo review the current reproductive advances in insulin-sensitizing agents for treatment of polycystic ovary syndrome patients.Recent findingsTo date, among insulin-sensitizing drugs, only metformin should be used to improve reproductive ...
Zullo, Fulvio +3 more
core +1 more source
Enhancement of radiation effectiveness in cervical cancer cells by combining ionizing radiation with hyperthermia and molecular targeting agents [PDF]
, 2018 Hyperthermia (HT) and molecular targeting agents can be used to enhance the effect of radiotherapy (RT). The purpose of this paper is to evaluate radiation sensitization by HT and different molecular targeting agents (Poly [ADP-ribose] polymerase 1 ...
Stalpers, Lukas J. A. +17 more
core +1 more source
Surgical adjuvant therapy in colon carcinoma: A human tumor spheroid model for evaluating radiation sensitizing agents [PDF]
Cancer, 1981 HT-29 human colon tumor cells growing as spheroids have been evaluated as a model system for measuring the response of human colon tumor cell to antineoplastic agents. HT-29 cells have been capacity to form spheroids up to 1 mm or more in diameter when grown in spinner culture.
R M, Barone +4 more
openaire +2 more sources
Dose-Response, 2007 Routine diagnostic X-rays (e.g., chest X-rays, mammograms, computed tomography scans) and routine diagnostic nuclear medicine procedures using sparsely ionizing radiation forms (e.g., beta and gamma radiations) stimulate the removal of precancerous ...
Bobby R. Scott, Jennifer Di Palma
doaj +1 more source
Fluoroquinolones as enhancers of photocarcinogenesis: Proposed pathomechanisms
Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2022 Fluoroquinolones are photosensitizing drugs in humans, as they can enhance effects of ultraviolet A (UVA) radiation on the skin. UVA causes lesions both to deoxyribonucleic acid and other cellular organelles by Type I and Type II reactions (major and ...
Ricardo Toipa Lopes, Margarida Gonçalo
doaj
Intravenous Iodinated Contrast Agents Amplify DNA Radiation Damage at CT [PDF]
, 2015 PURPOSE To determine the effect of the use of iodinated contrast agents on the formation of DNA double-strand breaks during chest computed tomography (CT).
Piechowiak, Eike I +4 more
core +1 more source
Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair [PDF]
, 2010 As single agents, chemical inhibitors of poly(ADP-ribose) polymerase (PARP) are nontoxic and have clinical efficacy against BRCA1- and BRCA2-deficient tumors.
Atsushi Shibata +17 more
core +4 more sources
NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin
Scientific Reports, 2017 NEK family kinases are serine/threonine kinases that have been functionally implicated in the regulation of the disjunction of the centrosome, the assembly of the mitotic spindle, the function of the primary cilium and the DNA damage response. NEK1 shows
Talita D. Melo-Hanchuk +13 more
doaj +1 more source
Changes in Radiation Sensitivity and Steroid Receptor Content Induced by Hormonal Agents and Ionizing Radiation in Breast Cancer Cells in Vitro [PDF]
Acta Oncologica, 1996 Possible influences of tamoxifen and estradiol on in vitro radiation sensitivity and cellular receptor content after irradiation and/or tamoxifen treatment were studied in breast cancer cell lines; estrogen receptor (ER) and progesterone receptor (PgR) positive cell lines MCF-7 and MCF-7/TAM(R)-1 and the ER and PgR negative cell line MDA-MB-231.
G H, Paulsen +3 more
openaire +2 more sources
Molecular Targets of TRAIL-Sensitizing Agents in Colorectal Cancer [PDF]
, 2012 Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL), a member of the TNF superfamily, interacts with its functional death receptors (DRs) and induces apoptosis in a wide range of cancer cell types.
PALLONE, FRANCESCO +7 more
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