Results 71 to 80 of about 28,129 (278)

Radiation therapy toxicity to the skin

, 2017
Radiation therapy has been integral to cancer patient care. The skin is an intentional and unintentional target of therapy, and is sensitive to the volume of normal tissue in the radiation therapy treatment field, daily treatment dose (fractionation ...
Bishop-Jodoin, Maryann, Britton, Maureen, Balducci, Susan, Arous, Edward J., FitzGerald, Thomas J, Lo, Y C., Ulin, Kenneth, McCauley, Shelagh, Mayo, Charles, Ding, Linda, Huang, Jiayi, Tillman, Gayle, Meyer, Joshua, Kadish, Sidney P., Urie, Marcia M., Pieters, Richard S., Cicchetti, M Giulia., Aronowitz, Jesse N., Sawicka, Joanna   +18 more
core   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Targeting mTOR and survivin concurrently potentiates radiation therapy in renal cell carcinoma by suppressing DNA damage repair and amplifying mitotic catastrophe

Journal of Experimental & Clinical Cancer Research
Background Renal cell carcinoma (RCC) was historically considered to be less responsive to radiation therapy (RT) compared to other cancer indications.
Hari K. Rachamala, Vijay S. Madamsetty, Ramcharan S. Angom, Naga M. Nakka, Shamit Kumar Dutta, Enfeng Wang, Debabrata Mukhopadhyay, Krishnendu Pal   +7 more
doaj   +1 more source

UBE2O Drives Immune Evasion and Radioimmunotherapy Resistance in Lung Cancer by Degrading CDKL1 to Induce PD‐L1 Transcription

Advanced Science, EarlyView.
UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue, Xiaohua Jie, Zhiwei Liu, Ruoxin Fang, Shuo Wu, Xiaorong Dong, Shuangbing Xu   +6 more
wiley   +1 more source

Assessment of the Sensitivity of Some Plant Pathogenic Fungi to 6-Demethylmevinolin, a Putative Natural Sensitizer Able to Help Overcoming the Fungicide Resistance of Plant Pathogens

, 2020
Agricultural fungicides contaminate the environment and promote the spread of fungicide-resistant strains of pathogenic fungi. The enhancement of pathogen sensitivity to these pesticides using chemosensitizers allows the reducing of fungicide dosages ...
Natalia Statsyuk, Vitaly Dzhavakhiya, Maksim Kartashov, Tatyana Pasechnik, Larisa Shcherbakova   +4 more
core   +1 more source

Thermometric Based‐Microswimmers with Chemical and Optical Engines

Advanced Intelligent Systems, EarlyView.
Temperature sensing at small scales is typically performed using passive luminescent particles. Here, an alternative approach is demonstrated by integrating upconversion thermometry into self‐propelled microswimmers powered by chemical fuels or light. This strategy offers a step toward dynamic thermal sensing at the microscale, relevant to both lab‐on ...
João M. Gonçalves, Katherine Villa
wiley   +1 more source

Controlling Biogenesis and Engineering of Exosomes to Inhibit Growth and Promote Death in Glioblastoma Multiforme

Brain Sciences
Glioblastoma multiforme (GBM) is characterized by aggressive growth, extensive vascularization, high metabolic malleability, and a striking capacity for therapy resistance.
Srikar Alapati, Swapan K. Ray
doaj   +1 more source

Combined exposure to natural UV radiation and irritant, sensitizing and photosensitizing substances

, 2010
Celem pracy badawczej była ocena narażenia zawodowego pracowników na łączne oddziaływanie naturalnego promieniowania UV i czynników chemicznych. Reprezentatywną grupą pracowników narażonych na łączne oddziaływanie szkodliwych dla zdrowia czynników była ...
Pośniak, M., Wolska, A., Szewczyńska, M., Głogowski, P.   +3 more
core  

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Effect of nanoparticles and x-ray(2-20)MeV on sensitivity enhancement ratio in brain malignant cells

Journal of Kufa-Physics, 2016
The importance of this research is to reduce the number of radiotherapy sessions that are given to patients with brain cancer then result in reducing the side effects of radiation therapy.
Nihad A. Saleh, Talib A. Abdul Wahid
doaj