Results 71 to 80 of about 120,136 (313)

The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation [PDF]

, 2009
The ataxia telangiectasia mutated (ATM) and the ATM- related (ATR) kinases play a central role in facilitating the resistance of cancer cells to genotoxic treatment regimens.
John P Alao, Per Sunnerhagen, KA Cimprich, MF Lavin, BB Zhou, JN Sarkaria, JP Alao, I Hickson, IG Cowell, J Won, S Bhattacharya, S Cruet-Hennequart, M Goldstein, XH Yang, E Crescenzi, DA Gewirtz, P Kahlem, LW Elmore, R Marcotte, RS Roberson, A Seluanov, J Wendt, HE Bryant, RD Kennedy, P Skehan, JP Alao, JR Alt, JA Diehl, ES Knudsen, JP Alao, ZN Demidenko, BD Chang, M Hitomi, C Nakai-Murakami, AZ Al-Minawi, M Yamauchi   +35 more
core   +2 more sources

A Preliminary Investigation of Radiation-Sensitive Ultrasound Contrast Agents for Photon Dosimetry

Pharmaceuticals
Radiotherapy treatment plans have become highly conformal, posing additional constraints on the accuracy of treatment delivery. Here, we explore the use of radiation-sensitive ultrasound contrast agents (superheated phase-change nanodroplets) as dosimetric radiation sensors.
Carlier, Bram, Heymans, Sophie, Nooijens, Sjoerd, Collado-Lara, Gonzalo, Toumia, Yosra, Delombaerde, Laurence, Paradossi, Gaio, D'hooge, Jan, Van Den Abeele, Koen, Sterpin, Edmond, Himmelreich, Uwe   +10 more
openaire   +7 more sources

Biodegradable and Recyclable Luminescent Mixed‐Matrix‐Membranes, Hydrogels, and Cryogels based on Nanoscale Metal‐Organic Frameworks and Biopolymers

Advanced Functional Materials, EarlyView.
The study presents biodegradable and recyclable mixed‐matrix membranes (MMMs), hydrogels, and cryogels using luminescent nanoscale metal‐organic frameworks (nMOFs) and biopolymers. These bio‐nMOF‐MMMs combine europium‐based nMOFs as probes for the status of the materials with the biopolymers agar and gelatine and present alternatives to conventional ...
Moritz Maxeiner, Julian Burkhart, Kateryna Borysova, Chiara Mazzariol, Klaus Müller‐Buschbaum   +4 more
wiley   +1 more source

ULTRASOUND APPLICATION FOR TREATMENT OF ONCOLOGICAL DISEASES

Наука и техника, 2012
The paper proposes methods for treatment of oncological diseases while applying ultrasound as an independent method and modifier of radiation therapy.Experimental and clinical investigations show effectiveness of ultrasound as an independent remedy ...
V. T. Minchenya, A. I. Babrouskaya, D. V. Chizh   +2 more
doaj  

A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation

Nucleic Acids Research, 2015
MicroRNAs (miRNAs) have been implicated in DNA repair pathways through transcriptional responses to DNA damaging agents or through predicted miRNA regulation of DNA repair genes.
K. Hatano, B. Kumar, Yonggang Zhang, J. Coulter, M. Hedayati, Brian M Mears, Xiaohua Ni, Tarana A. Kudrolli, W. Chowdhury, R. Rodriguez, T. DeWeese, Shawn E Lupold   +11 more
semanticscholar   +1 more source

Infrared Nanocrystals for Space Application: Hardness to Irradiations

Advanced Functional Materials, EarlyView.
This article investigates infrared HgTe nanocrystals under X‐ray and ion irradiation, revealing remarkable radiation hardness. It uncovers distinct degradation mechanisms and shows that the nanomaterial outperforms integrated electronics. The results position colloidal nanocrystals as promising candidates for resilient space and harsh‐environment ...
Alexandre Neyret, Dario Mastrippolito, Bingbing Xia, Adrien Khalili, Maxime Lebreton, Giorgia Strobbia, Albin Colle, Marco Paye, Mariarosa Cavallo, Erwan Bossavit, Claire Abadie, Yoann Prado, Debora Pierucci, Victor Parahyba, Francois Coursaget, David Darson, Emrick Briand, Ian Vickridge, Stephane Demiguel, Sebastien Massenot, Jean‐Marc Belloir, Vincent Goiffon, Emmanuel Lhuillier   +22 more
wiley   +1 more source

An investigation on benefits and future expectation of Industrialised Building System (IBS) implementation in construction practices [PDF]

, 2018
Industrialised Building System (IBS) is well known in many developing countries due to the benefits that can be derived from its applications in construction projects. However, the low percentage of IBS usage may be due to lack of awareness and knowledge
Akasah, Zainal Abidin, Ismail, Hassan, Khamis, Azme, Nagapan, Sasitharan   +3 more
core   +1 more source

Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges

Advanced Functional Materials, EarlyView.
Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley   +1 more source

Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy

Advanced Functional Materials, EarlyView.
This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez, Jose I. Garcia‐Peiro, Jose L. Hueso, Eduardo Caleiras, Laura Notario, Felipe Hornos, Pilar Martin‐Duque, Antonio De la Vieja, Jesus Santamaria   +8 more
wiley   +1 more source

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source