Results 71 to 80 of about 15,150 (235)
Advanced Science, EarlyView.Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan +11 more
wiley +1 more source
Radiation sensitizing effect of COX-2 inhibitor, celecoxib, in HCT-116 colorectal cancer cell line [PDF]
, 2005 의과학과/석사[한글] 대장암은 서구에서 가장 많은 암종이며 최근 우리 나라에서 크게 증가하고 있는 추세로, 대장암에 대한 화학적 예방에 대한 연구도 활발히 진행되고 있다. 그 중 대표적인 예가 cyclooxygenase (COX)-2와 그의 억제제에 대한 연구이다. COX-2는 여러 암 세포에서 항시적으로 발현되는 것으로 알려져 있으며, 대장암 세포주를 포함한 여러 암세포주에서 COX-2의 선택적 억제제가 발암을 방지하는 효과가 있고, 생체 내외에서
김현석
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A Pooled Analysis of Thyroid Cancer Incidence Following Radiotherapy for Childhood Cancer [PDF]
, 2012 Childhood cancer five-year survival now exceeds 70-80%. Childhood exposure to radiation is a known thyroid carcinogen; however, data are limited for the evaluation of radiation dose-response at high doses, modifiers of the dose-response relationship and ...
de Vathaire, Florent +26 more
core +1 more source
Advanced Science, EarlyView.UBE2O targets CDKL1 for the degradation to upregulate PD‐L1 expression and promotes resistance to radioimmunotherapy in lung cancer, supporting the potential of targeting UBE2O as a promising therapeutic strategy. ABSTRACT Resistance to radioimmunotherapy is one of the primary causes of treatment failure in lung cancer patients; however, the underlying
Huichan Xue +6 more
wiley +1 more source
Implantable MEMS drug delivery device for cancer radiation reduction [PDF]
, 2010 We present the first implantable MEMS drug delivery device that includes an electrochemical bellows pump, refillable drug reservoir, and dual regulation valve. Multiple drug pump configurations were fabricated, assembled, and tested.
Uttam K. Sinha +10 more
core +2 more sources
Advanced Science, EarlyView.Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen +17 more
wiley +1 more source
Selective PARP-1 Targeting for Designing Chemo/Radio Sensitizing Agents [PDF]
, 2006 Poly(ADP-ribose) polymerase-1 (PARP-1) is a central signaling enzyme in a cell nucleus. PARP-1 is a target for the development of radio and chemo sensitizing agents in cancer treatment as well as providing protection from stroke. An SH3 domain and an SH3
Oliveira, Marcos
core +1 more source
In vivo interactions between ionizing radiation, inflammation and chemical carcinogens identified by increased DNA damage responses [PDF]
, 2012 Exposure to ionizing radiation or a variety of chemical agents is known to increase the risk of developing malignancy and many tumors have been linked to inflammatory processes.
Lorimore, S.A. +3 more
core +1 more source
Advanced Science, EarlyView.USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen +7 more
wiley +1 more source
University of California Radiation Laboratory Reports UCRL-1743 [PDF]
, 1952 A controversy exists as to the effect of inositol and other lipotropic agents on serum cholesterol levels and atherosclerosis in humans and animals. There is no general agreement that these agents lower serum cholesterol levels or exert an inhibitory ...
Kritchevsky, David, 1920-2006 +1 more
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