Results 261 to 270 of about 120,136 (313)
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International Journal of Radiation Biology, 2010
To better predict radiation-drug interactions in in vitro model systems, thorough assessment of the effects of in vitro exposure is required. The aim of this article is to show that both clonogenic capacity and cellular proliferation, which represent important different elements of tumour conduct, can be considered when assessing in vitro radio ...
Luttjeboer, M. +7 more
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To better predict radiation-drug interactions in in vitro model systems, thorough assessment of the effects of in vitro exposure is required. The aim of this article is to show that both clonogenic capacity and cellular proliferation, which represent important different elements of tumour conduct, can be considered when assessing in vitro radio ...
Luttjeboer, M. +7 more
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Radiation sensitizing agents in clinical radiation and chemotherapy.
Journal of medicine, 1980Patients with bronchogenic carcinoma or with advanced pediatric solid tumours were treated with various radiation therapy schedules alone or with a new alkylating carbamate: AB 132. Drug therapy appeared to potentiate radiation therapy results without significant toxicity except for certain neurologic symptoms (myasthenia, nightmares, disturbances of ...
J L, Ambrus +3 more
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Biophysik, 1973
The inactivation of three radiation-sensitive haploidSaccharomyces mutants, as well as that of corresponding homozygous diploid mutants, following treatment with the bifunctional alkylating agent diepoxybutane (DEB) or the monofunctional alkylating agents methylmethane-sulfonate (MMS) or methylnitrosoguanidine (MNG) was investigated.
W, Laskawski, E, Lehmann-Brauns
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The inactivation of three radiation-sensitive haploidSaccharomyces mutants, as well as that of corresponding homozygous diploid mutants, following treatment with the bifunctional alkylating agent diepoxybutane (DEB) or the monofunctional alkylating agents methylmethane-sulfonate (MMS) or methylnitrosoguanidine (MNG) was investigated.
W, Laskawski, E, Lehmann-Brauns
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Radiation sensitizing and radiation protective agents in experimental radiation therapy.
Journal of medicine, 1989It appears that AB-132 potentiates radiation effects, and the local application of AET (MEG) protects the intestinal tract, the bladder and the skin against radiation toxicity. Combined use of selective radiation sensitizing and protecting agents may be considered for clinical studies.
J L, Ambrus +4 more
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Modulation of Alkylating Agents by Radiation Sensitizers— Clinical Aspects
1986Alkylating agents are among the most commonly used anticancer agents. They have the widest spectrum of antitumor activity of any class of agents. Individual alkylating agents usually are not cross resistant, since the mechanisms and sites of alkylation of each agent may differ considerably.
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International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1973
SummaryMeasurements were made of the synthesis of DNA by membrane-DNA complexes extracted from Escherichia coli B/r that had been sensitized to or protected against the lethal effects of ionizing radiation by irradiating the bacteria in the presence of indane trione, acriflavine, thiourea, or β-mercaptoethanol. Pre-irradiation treatment of the bacteria
W A, Cramp, H N, Fraval, J, Collins
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SummaryMeasurements were made of the synthesis of DNA by membrane-DNA complexes extracted from Escherichia coli B/r that had been sensitized to or protected against the lethal effects of ionizing radiation by irradiating the bacteria in the presence of indane trione, acriflavine, thiourea, or β-mercaptoethanol. Pre-irradiation treatment of the bacteria
W A, Cramp, H N, Fraval, J, Collins
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Enhancement of antitumor activity of alkylating agents by the radiation sensitizer misonidazole.
Cancer research, 1981The influence of the radiosensitizer misonidazole on the effectiveness of several alkylating agents and cis-platinum against advanced solid murine tumors was investigated. Tumor regrowth delay, frequency of tumor regressions, and animal life span were used to evaluate misonidazole in combination with cyclophosphamide, L-phenylalanine mustard, 1-(2 ...
J J, Clement +4 more
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Radiation Research, 1984
Pretreatment of V79- WNRE cells with 150 microM diethylmaleate for 1 hr at 37 degrees C caused a decrease in intracellular glutathione levels to approximately 10-15% of control levels (0.5 vs 5.0 nmol/10(6) cells). The cells could be washed free of diethylmaleate and held at 0 degree C for several hours without toxicity and with no increase in ...
C J, Koch, C C, Stobbe, E A, Bump
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Pretreatment of V79- WNRE cells with 150 microM diethylmaleate for 1 hr at 37 degrees C caused a decrease in intracellular glutathione levels to approximately 10-15% of control levels (0.5 vs 5.0 nmol/10(6) cells). The cells could be washed free of diethylmaleate and held at 0 degree C for several hours without toxicity and with no increase in ...
C J, Koch, C C, Stobbe, E A, Bump
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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1987
To determine the mutual relationships between cell survival and induction of sister-chromatid exchanges (SCEs) as well as chromosomal aberrations (CAs), mutagen-induced SCEs and CAs were analyzed in an ionizing radiation-sensitive mutant (M10) and an alkylating agent-sensitive mutant (MS 1) isolated from mouse lymphoma L5178Y cells.
H, Tsuji +5 more
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To determine the mutual relationships between cell survival and induction of sister-chromatid exchanges (SCEs) as well as chromosomal aberrations (CAs), mutagen-induced SCEs and CAs were analyzed in an ionizing radiation-sensitive mutant (M10) and an alkylating agent-sensitive mutant (MS 1) isolated from mouse lymphoma L5178Y cells.
H, Tsuji +5 more
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Anticancer research, 1995
We studied whether cellular sensitivity to anticancer agents was correlated with a repair deficiency in three yeast epistasis groups of radiation sensitive mutants. All these mutants were hypersensitive to cisplatin and mitomycin C. By contrast, both rad51 and rad52 mutants deficient in double-strand breaks repair were hypersensitive to adriamycin and ...
H, Abe, M, Wada, K, Kohno, M, Kuwano
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We studied whether cellular sensitivity to anticancer agents was correlated with a repair deficiency in three yeast epistasis groups of radiation sensitive mutants. All these mutants were hypersensitive to cisplatin and mitomycin C. By contrast, both rad51 and rad52 mutants deficient in double-strand breaks repair were hypersensitive to adriamycin and ...
H, Abe, M, Wada, K, Kohno, M, Kuwano
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