Results 241 to 250 of about 28,129 (278)

Radiation Sensitization by Thiol-Binding Agents of Radioresistant and Radiosensitive Escherichia coli and the Oxygen Effect

Radiation Research, 1968
Dose-survival curves of four strains of E. coli-B/r her- try-, Bs-1, B/r CSH, and 15T-were obtained in the presence and in the absence of non-toxic levels of several thiol-binding agents-N-ethylmaleimide (NEM), iodoacetamide (IA), and hydroxymercuribenzoate (HMB). The degree of radiosensitization by these agents was estimated from the increase in slope
H, Moroson, D N, Tenney
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Enhancement of Alkylating Agent Cytotoxicity by Radiation Sensitizers

1986
Animal tumors having a wide range of growth rates and histologies have been shown to contain hypoxic cells (1), which largely determine the radiation dose necessary for tumor control. Nonetheless, the nearly universal presence of hypoxic cells in solid tumors in rodents does not prove that the same is true of human tumors.
J. Martin Brown, David G. Hirst, Michael R. Horsman, Yvonne C. Taylor   +3 more
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Radiation sensitivity modification by chemotherapeutic agents.

Cancer clinical trials, 1981
Three chemotherapeutic agents, chlorambucil, mustargen, and BCNU-409962, being investigated for their possible clinical use in conjunction with radiation therapy have been shown in vitro to dramatically affect the characteristics of standard radiation survival curves (in V79 cells and spheroids).
F W, Hetzel, M, Brown, N, Kaufman, H I, Bicher   +3 more
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Synthesis of potential dual-acting radiation sensitizer antineoplastic agents: 2,2-dimethylphosphoraziridines containing 2-nitroimidazoles or other electron-affinic moieties

Journal of Medicinal Chemistry, 1991
In view of the in vivo demonstrated radiation-potentiating activities of several previously studied 2,2-dimethylphosphoraziridines, six new compounds incorporating the bis(2,2-dimethyl-1-aziridinyl)phosphinyl moiety, together with an electron-affinic group such as 2-nitroimidazole or nitrobenzyl, have been synthesized and tested (1) in vitro for ...
M E, Perlman, J A, Dunn, T A, Piscitelli, J, Earle, W C, Rose, G L, Wampler, J E, MacDiarmid, T J, Bardos   +7 more
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Radiation sensitizing agents in clinical radiation and chemotherapy.

Journal of medicine, 1980
Patients with bronchogenic carcinoma or with advanced pediatric solid tumours were treated with various radiation therapy schedules alone or with a new alkylating carbamate: AB 132. Drug therapy appeared to potentiate radiation therapy results without significant toxicity except for certain neurologic symptoms (myasthenia, nightmares, disturbances of ...
J L, Ambrus, C M, Ambrus, T J, Bardos, Z F, Chmielewicz   +3 more
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The Effect of Radiation Sensitizing and Protective Agents on the Post-irradiation Synthesis of DNA by Membrane Complexes of Escherichia Coli B/r

International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1973
SummaryMeasurements were made of the synthesis of DNA by membrane-DNA complexes extracted from Escherichia coli B/r that had been sensitized to or protected against the lethal effects of ionizing radiation by irradiating the bacteria in the presence of indane trione, acriflavine, thiourea, or β-mercaptoethanol. Pre-irradiation treatment of the bacteria
W A, Cramp, H N, Fraval, J, Collins
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Cross sensitivity to mono- and bifunctional alkylating agents of three radiation-sensitiveSaccharomyces mutants

Biophysik, 1973
The inactivation of three radiation-sensitive haploidSaccharomyces mutants, as well as that of corresponding homozygous diploid mutants, following treatment with the bifunctional alkylating agent diepoxybutane (DEB) or the monofunctional alkylating agents methylmethane-sulfonate (MMS) or methylnitrosoguanidine (MNG) was investigated.
W, Laskawski, E, Lehmann-Brauns
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Modulation of Alkylating Agents by Radiation Sensitizers— Clinical Aspects

1986
Alkylating agents are among the most commonly used anticancer agents. They have the widest spectrum of antitumor activity of any class of agents. Individual alkylating agents usually are not cross resistant, since the mechanisms and sites of alkylation of each agent may differ considerably.
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Radiation sensitizing and radiation protective agents in experimental radiation therapy.

Journal of medicine, 1989
It appears that AB-132 potentiates radiation effects, and the local application of AET (MEG) protects the intestinal tract, the bladder and the skin against radiation toxicity. Combined use of selective radiation sensitizing and protecting agents may be considered for clinical studies.
J L, Ambrus, J, Halpern, T, Bardos, Z F, Chmielwicz, E, Klein   +4 more
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The Effect on the K m for Radiosensitization at 0 degrees C of Thiol Depletion by Diethylmaleate Pretreatment: Quantitative Differences Found Using the Radiation Sensitizing Agent Misonidazole or Oxygen

Radiation Research, 1984
Pretreatment of V79- WNRE cells with 150 microM diethylmaleate for 1 hr at 37 degrees C caused a decrease in intracellular glutathione levels to approximately 10-15% of control levels (0.5 vs 5.0 nmol/10(6) cells). The cells could be washed free of diethylmaleate and held at 0 degree C for several hours without toxicity and with no increase in ...
C J, Koch, C C, Stobbe, E A, Bump
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