Results 251 to 260 of about 120,136 (313)

Combined Radiation-Protective and Radiation-Sensitizing Agents: II. Radiosensitivity of Hypoxic or Aerobic Chinese Hamster Fibroblasts in the Presence of Cysteamine and Misonidazole: Implications for the "Oxygen Effect" (With Appendix on Calculation of Dose-Modifying Factors)

Radiation Research, 1981
Experiments have been done to test whether a hypoxic cell radiosensitizing agent (misonidazole) can be combined with a radioprotecting agent (cysteamine) to equalize partially the radiation response of hypoxic and aerobic mammalian cells in tissue culture.
C J, Koch, R L, Howell
openaire   +3 more sources

Clinical use of radiation sensitizing agents

Cancer Treatment Reviews, 1974
D R, Goffinet, M A, Bagshaw
openaire   +3 more sources

Design, synthesis and molecular modeling study of certain 4-Methylbenzenesulfonamides with CDK2 inhibitory activity as anticancer and radio-sensitizing agents.

Bioorganic chemistry (Print), 2018
Two series of 2-aminopyridine derivatives 6-17 and tyrphostin AG17 analogs 18-22 bearing 4-methylbenzenesulfonamide moiety were designed and synthesized as anticancer compounds.
M. Ghorab, F. Ragab, H. Heiba, M. S. Elsayed, Walid M. Ghorab   +4 more
semanticscholar   +1 more source

Radiation sensitivity of bacteria and virus in porcine xenoskin for dressing agent

Radiation Physics and Chemistry, 2012
Abstract In this study, gamma irradiation sensitivities of bacteria and viruses in porcine skin were evaluated to establish the optimum sterilization condition for the dressing material and a xenoskin graft. Escherichia coli and Bacillus subtilis were used as model pathogens and inoculated at 106–107 log CFU/g.
Eu-Ri Jo, Pil-Mun Jung, Jong-il Choi, Ju-Woon Lee   +3 more
openaire   +1 more source

Breast cancer cells are sensitized by piperine to radiotherapy through estrogen receptor-α mediated modulation of a key NHEJ repair protein- DNA-PK.

Phytomedicine, 2023
BACKGROUND Non-homologous end joining, an important DNA-double-stranded break repair pathway, plays a prominent role in conferring resistance to radiotherapeutic agents, resulting in cancer progression and relapse.
K. Shaheer, BR Swathi Prabhu, H. S. Ali, Divya Lakshmanan-M   +3 more
semanticscholar   +1 more source

An oxygenation agent and radiation sensitizer, dodecafluoropentane, for the treatment of glioblastoma multiforme.

Journal of Clinical Oncology, 2015
TPS2078 Background: Post-resected glioblastoma multiforme (GMB) patients were treated with dodecafluoropentane emulsion (DDFPe) to evaluate the pharmacokinetics (PK), safety and potential survival ...
Jason D. Lickliter, David Brown Wilson, Howard Hendrickson, Natarajan Raghunand, Soo-Peang Khor, Olivia Longacre, Evan C. Unger   +6 more
openaire   +1 more source

Synthesis of potential dual-acting radiation sensitizer antineoplastic agents: 2,2-dimethylphosphoraziridines containing 2-nitroimidazoles or other electron-affinic moieties

Journal of Medicinal Chemistry, 1991
In view of the in vivo demonstrated radiation-potentiating activities of several previously studied 2,2-dimethylphosphoraziridines, six new compounds incorporating the bis(2,2-dimethyl-1-aziridinyl)phosphinyl moiety, together with an electron-affinic group such as 2-nitroimidazole or nitrobenzyl, have been synthesized and tested (1) in vitro for ...
M E, Perlman, J A, Dunn, T A, Piscitelli, J, Earle, W C, Rose, G L, Wampler, J E, MacDiarmid, T J, Bardos   +7 more
openaire   +3 more sources

Enhancement of Alkylating Agent Cytotoxicity by Radiation Sensitizers

1986
Animal tumors having a wide range of growth rates and histologies have been shown to contain hypoxic cells (1), which largely determine the radiation dose necessary for tumor control. Nonetheless, the nearly universal presence of hypoxic cells in solid tumors in rodents does not prove that the same is true of human tumors.
J. Martin Brown, David G. Hirst, Michael R. Horsman, Yvonne C. Taylor   +3 more
openaire   +1 more source

Radiation Sensitization by Thiol-Binding Agents of Radioresistant and Radiosensitive Escherichia coli and the Oxygen Effect

Radiation Research, 1968
Dose-survival curves of four strains of E. coli-B/r her- try-, Bs-1, B/r CSH, and 15T-were obtained in the presence and in the absence of non-toxic levels of several thiol-binding agents-N-ethylmaleimide (NEM), iodoacetamide (IA), and hydroxymercuribenzoate (HMB). The degree of radiosensitization by these agents was estimated from the increase in slope
H, Moroson, D N, Tenney
openaire   +2 more sources

Radiation sensitivity modification by chemotherapeutic agents.

Cancer clinical trials, 1981
Three chemotherapeutic agents, chlorambucil, mustargen, and BCNU-409962, being investigated for their possible clinical use in conjunction with radiation therapy have been shown in vitro to dramatically affect the characteristics of standard radiation survival curves (in V79 cells and spheroids).
F W, Hetzel, M, Brown, N, Kaufman, H I, Bicher   +3 more
openaire   +1 more source