Results 251 to 260 of about 28,129 (278)
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Enhancement of antitumor activity of alkylating agents by the radiation sensitizer misonidazole.

Cancer research, 1981
The influence of the radiosensitizer misonidazole on the effectiveness of several alkylating agents and cis-platinum against advanced solid murine tumors was investigated. Tumor regrowth delay, frequency of tumor regressions, and animal life span were used to evaluate misonidazole in combination with cyclophosphamide, L-phenylalanine mustard, 1-(2 ...
J J, Clement   +4 more
openaire   +1 more source

Combined Radiation-Protective and Radiation-Sensitizing Agents: II. Radiosensitivity of Hypoxic or Aerobic Chinese Hamster Fibroblasts in the Presence of Cysteamine and Misonidazole: Implications for the "Oxygen Effect" (With Appendix on Calculation of Dose-Modifying Factors)

Radiation Research, 1981
Experiments have been done to test whether a hypoxic cell radiosensitizing agent (misonidazole) can be combined with a radioprotecting agent (cysteamine) to equalize partially the radiation response of hypoxic and aerobic mammalian cells in tissue culture.
C J, Koch, R L, Howell
openaire   +2 more sources

Chromosomal instability in mutagen-sensitive mutants isolated from mouse lymphoma L5178Y cells II. Abnormal induction of sister-chromatid exchanges and chromosomal aberrations by mutagens in an ionizing radiation-sensitive mutant (M10) and an alkylating agent-sensitive mutant (MS 1)

Mutation Research, 1987
To determine the mutual relationships between cell survival and induction of sister-chromatid exchanges (SCEs) as well as chromosomal aberrations (CAs), mutagen-induced SCEs and CAs were analyzed in an ionizing radiation-sensitive mutant (M10) and an alkylating agent-sensitive mutant (MS 1) isolated from mouse lymphoma L5178Y cells.
H, Tsuji   +5 more
openaire   +2 more sources

Altered drug sensitivities to anticancer agents in radiation-sensitive DNA repair deficient yeast mutants.

Anticancer research, 1995
We studied whether cellular sensitivity to anticancer agents was correlated with a repair deficiency in three yeast epistasis groups of radiation sensitive mutants. All these mutants were hypersensitive to cisplatin and mitomycin C. By contrast, both rad51 and rad52 mutants deficient in double-strand breaks repair were hypersensitive to adriamycin and ...
H, Abe, M, Wada, K, Kohno, M, Kuwano
openaire   +1 more source

[Radiation sensitizing agents for hypoxic cells: past, present and future].

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 1999
Hypoxic cells are present in rodent and xenografted human tumours and it has been known for a long time that the absence of oxygen in tumours is a factor of resistance against ionising radiation. The dose modifying role of oxygen (oxygen enhancement ratio) has been largely studied in experimental models.
openaire   +1 more source

[Clinical experiences with the radiation-sensitizing agent misonidazole].

Strahlentherapie. Sonderbande, 1981
H D, Kogelnik   +3 more
openaire   +1 more source

Radiation-Protective Agents in Mammals

Journal of Pharmaceutical Sciences, 1969
William O Foye
exaly  

[Biochemical effect of certain radiation-sensitizing agents].

Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1972
C, Streffer, K, Schweiger
openaire   +1 more source

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