Development of a Preclinical Therapeutic Model of Human Brain Metastasis with Chemoradiotherapy [PDF]
, 2013 Currently, survival of breast cancer patients with brain metastasis ranges from 2 to 16 months. In experimental brain metastasis studies, only 10% of lesions with the highest permeability exhibited cytotoxic responses to paclitaxel or doxorubicin ...
Hernández, Vanessa +4 more
core +3 more sources
Targeting ATM pathway for therapeutic intervention in cancer [PDF]
, 2012 The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Chakarov, Stoyan +4 more
core +3 more sources
Evaluation of melanin-targeted radiotherapy in combination with radiosensitizing drugs for the treatment of melanoma [PDF]
, 2014 The incidence of malignant melanoma is rising faster than that of any other cancer in the United States. An [131I]-labeled benzamide - [131I]MIP-1145 - selectively targets melanin, reduces melanoma tumor burden and increases survival in preclinical ...
Babich, John +5 more
core +1 more source
Evaluation of the radiosensitizing potency of chemotherapeutic agents in prostate cancer cells [PDF]
, 2016 PURPOSE: Despite recent advances in the treatment of metastatic prostate cancer, survival rates are low and treatment options are limited to chemotherapy and hormonal therapy.
Mairs, Robert J., Rae, Colin
core +2 more sources
Antitumor activities of metal oxide nanoparticles [PDF]
, 2015 Nanoparticles have received much attention recently due to their use in cancer therapy. Studies have shown that different metal oxide nanoparticles induce cytotoxicity in cancer cells, but not in normal cells.
Mitjans Arnal, Montserrat +1 more
core +2 more sources
Dose-Response, 2007 Routine diagnostic X-rays (e.g., chest X-rays, mammograms, computed tomography scans) and routine diagnostic nuclear medicine procedures using sparsely ionizing radiation forms (e.g., beta and gamma radiations) stimulate the removal of precancerous ...
Bobby R. Scott, Jennifer Di Palma
doaj +1 more source
Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity [PDF]
, 2014 Photodynamic therapy is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with specific light activation of a photosensitizer agent.
Lamberti, María Julia +2 more
core +1 more source
Treating cutaneous T-cell lymphoma with highly irregular surfaces with photon irradiation using rice as tissue compensator. [PDF]
, 2015 PurposeCutaneous T-cell lymphoma (CTCL) is known to have an excellent response to radiotherapy, an important treatment modality for this disease.
Chakravarti, Arnab +9 more
core +2 more sources
Fluoroquinolones as enhancers of photocarcinogenesis: Proposed pathomechanisms
Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2022 Fluoroquinolones are photosensitizing drugs in humans, as they can enhance effects of ultraviolet A (UVA) radiation on the skin. UVA causes lesions both to deoxyribonucleic acid and other cellular organelles by Type I and Type II reactions (major and ...
Ricardo Toipa Lopes, Margarida Gonçalo
doaj
Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer. [PDF]
, 2018 BACKGROUND:Although canonical Wnt signaling is known to promote tumorigenesis in pancreatic ductal adenocarcinoma (PDAC), a cancer driven principally by mutant K-Ras, the detailed molecular mechanisms by which the Wnt effector β-catenin regulates such ...
Chen, Yibu +12 more
core +2 more sources