Results 71 to 80 of about 894,895 (306)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cumulative Radiation Damage and Cumulative Radiation Effect [PDF]

Acta Radiologica: Oncology, 1983
Different mathematical formulas capable of replacing CRE have been analyzed. The purpose was to develop an expression which would yield a value identical with CRE for regular treatment schedules, but would represent more clearly and more truthfully the radiation damage of tissue. This quantity has been called cumulative radiation damage (CRD). Its unit
openaire   +2 more sources

FISH comets show that the salvage enzyme TK1 contributes to gene-specific DNA repair

Frontiers in Genetics, 2014
Thymidine kinase 1 (TK1) is a salvage enzyme that phosphorylates thymidine, imported from surrounding fluids, to create dTMP, which is further phosphorylated to the DNA precursor dTTP.
Stephen eDownes, Valerie eMcKelvey-Martin, George eMcKerr, Katherine eMcAllister, Katherine eMcAllister, Akeel eal-Kufi, Akeel eal-Kufi   +6 more
doaj   +1 more source

Weak Localization Effect in Superconductors by Radiation Damage [PDF]

, 1999
Large reductions of the superconducting transition temperature $T_{c}$ and the accompanying loss of the thermal electrical resistivity (electron-phonon interaction) due to radiation damage have been observed for several A15 compounds, Chevrel phase and ...
A. D. Stone, A. Fetter, A. Hofmann, A.K. Ghosh, A.K. Ghosh, A.M. Goldman, A.R. Sweedler, A.R. Sweedler, A.R. Sweedler, A.R. Sweedler, A.T. Fiory, B.L. Altshuler, B.S. Brown, B.S. Brown, B.S. Brown, C. Kittel, C. L. Snead, Jr., C.C. Koch, C.C. Tsuei, C.L. Snead, Jr., C.L. Snead, Jr., D.A. Rudman, D.F. Farrell, D.G. Schweitzer, D.J. Thouless, D.J. Thouless, D.M. Parkin, E. Abrahams, G. Bergmann, G. Boato, G. Ischenko, G.M. Eliashberg, H. Gutfreund, H. Lutz, H. Wiesmann, H. Wiesmann, H. Wiesmann, J. Fink, J. Geerk, J.M. Poate, J.M. Poate, J.M. Valles, Jr., J.P. Orlando, K.E. Kihlstrom, L.R. Testardi, L.R. Testardi, L.R. Testardi, M. Gurvitch, M. Hitzfeld, M. Kaveh, M. Kaveh, M. Ma, M.F. Merriam, Mi-Ae Park, Mi-Ae Park, Mi-Ae Park, N.F. Mott, P. L. Taylor, P.A. Lee, P.W. Anderson, P.W. Anderson, R. Bett, R. C. Dynes, R. Viswanathan, R.A. Pollak, R.C. Dynes, S. V. Vonsovsky, S. V. Vonsovsky, S.J. Bending, T.A. Miller, W.L. McMillan, W.L. McMillan, Y. Dalichaouch, Y. Li, Yong-Jihn Kim, Yong-Jihn Kim, Yong-Jihn Kim, Yong-Jihn Kim, Yong-Jihn Kim, Yong-Jihn Kim   +79 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation Exposure

Academic Science Journal
Exposure to ionizing radiation destroys several biological processes by disturbing the membranes of cells and causing damage to DNA, proteins, and mitochondria.
Lina Al-jameel, Lujain Ghannawi, Safaa Ehssan, Haidar Fadhil, Mohammed Amir   +4 more
doaj   +1 more source