Results 51 to 60 of about 353,479 (266)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Radiation Damage of Reactor Pressure Vessel Steels Studied by Positron Annihilation Spectroscopy—A Review

Metals, 2020
Safe and long term operation of nuclear reactors is one of the most discussed challenges in nuclear power engineering. The radiation degradation of nuclear design materials limits the operational lifetime of all nuclear installations or at least ...
Vladimír Slugeň, Stanislav Sojak, Werner Egger, Vladimir Krsjak, Jana Simeg Veternikova, Martin Petriska   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Protective effects of leaf juice of Brassica rapa on radio-damage of mouse

浙江大学学报. 农业与生命科学版, 2001
The protection and repair effects of Brassica rapa leaf juice on radio-damage mouse induced by 60Coγ-rays were studied with the methods of measuring hemogram of mice, classifying of WBC, measuring wieght of the spleens and chest glands, and the ...
QIAN Xiao-wei, ZHU Mu-yuan, LIU Chun-lei, NI Xiang-yong, CHEN Xiao-qun   +4 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Effect of DNA Damage on the Development of Diabetes Mellitus due toIonizing Radiation Exposure

Academic Science Journal
Exposure to ionizing radiation destroys several biological processes by disturbing the membranes of cells and causing damage to DNA, proteins, and mitochondria.
Lina Al-jameel, Lujain Ghannawi, Safaa Ehssan, Haidar Fadhil, Mohammed Amir   +4 more
doaj   +1 more source

Study of Changes in Optical and Heat-Conducting Properties of AlN Ceramics under Irradiation with Kr¹⁵⁺ and Xe²²⁺ Heavy Ions

Nanomaterials, 2020
AlN-based ceramics have great prospects for use in the field of structural materials for reactors of the new generation of GenIV, as well as dosimetric and optical devices.
Artem L. Kozlovskiy, Maxim V. Zdorovets, Vladimir V. Uglov   +2 more
doaj   +1 more source

Cumulative Radiation Damage and Cumulative Radiation Effect [PDF]

Acta Radiologica: Oncology, 1983
Different mathematical formulas capable of replacing CRE have been analyzed. The purpose was to develop an expression which would yield a value identical with CRE for regular treatment schedules, but would represent more clearly and more truthfully the radiation damage of tissue. This quantity has been called cumulative radiation damage (CRD). Its unit
openaire   +2 more sources