Results 61 to 70 of about 2,871,612 (244)

Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity. [PDF]

, 2012
The recruitment kinetics of double-strand break (DSB) signaling and repair proteins Mdc1, 53BP1 and Rad52 into radiation-induced foci was studied by live-cell fluorescence microscopy after ion microirradiation.
Hilmar Strickfaden (148181), Guenther Dollinger, Brüning, Tino, Anja Derer, Judith Seel (148178), Volker Hable, Derer, Anja, Guido A Drexler, Burgdorf, Christian, Tino Brüning, Drexler, Guido A., Dollinger, Günther, Friedl, Anna A., Christoph Greubel, Greubel, Christoph, Thomas Cremer, Christian Burgdorf, Guido A. Drexler (148161), Christian Burgdorf (148169), Hable, Volker, Tino Brüning (148165), Hilmar Strickfaden, Judith Seel, Christoph Greubel (148173), Thomas Cremer (93), Günther Dollinger (148186), Anna A Friedl, Cremer, Thomas, Guido A. Drexler, Anna A. Friedl, Anja Derer (148175), Strickfaden, Hilmar, Günther Dollinger, Anna A. Friedl (148183), Seel, Judith, Volker Hable (148157)   +35 more
core   +2 more sources

Advancements in primary radiation damage models and SRIM simulations: A review of radiation damage predictions

Nuclear Engineering and Technology
Evaluating radiation damage in materials and devices is vital for their use in extreme environments, but accurate predictions are challenging due to uncertainties in traditional models like Primary Radiation Damage Models (PRDMs) and modern simulations ...
Zulfiqar Ali, Furong Liu, Yinghao Wang, Hafiz Ghullam Rasool, Feiying Wang, Muhammad Haseeb   +5 more
doaj   +1 more source

Fixed-target serial oscillation crystallography at room temperature

IUCrJ, 2019
A fixed-target approach to high-throughput room-temperature serial synchrotron crystallography with oscillation is described. Patterned silicon chips with microwells provide high crystal-loading density with an extremely high hit rate.
Jennifer L. Wierman, Olivier Paré-Labrosse, Antoine Sarracini, Jessica E. Besaw, Michael J. Cook, Saeed Oghbaey, Hazem Daoud, Pedram Mehrabi, Irina Kriksunov, Anling Kuo, David J. Schuller, Scott Smith, Oliver P. Ernst, Doletha M. E. Szebenyi, Sol M. Gruner, R. J. Dwayne Miller, Aaron D. Finke   +16 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Post-translational modification networks in tumor radiosensitivity: mechanistic insights and therapeutic opportunities

Journal of Translational Medicine
Background Radiotherapy is a central modality in cancer management, yet intrinsic and acquired radioresistance and dose-limiting normal tissue toxicities continue to constrain durable tumor control.
Xiaoli Lv, Jiao Xue, Jun Zhou, Qi Zhao, Yandong Liu, Lili Wang, Yang Jiao, Songbing Qin   +7 more
doaj   +1 more source

Radiation damage in small-molecule crystallography: fact not fiction

IUCrJ, 2019
Traditionally small-molecule crystallographers have not usually observed or recognized significant radiation damage to their samples during diffraction experiments.
Jeppe Christensen, Peter N. Horton, Charles S. Bury, Joshua L. Dickerson, Helena Taberman, Elspeth F. Garman, Simon J. Coles   +6 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Native SAD is maturing

IUCrJ, 2015
Native SAD phasing uses the anomalous scattering signal of light atoms in the crystalline, native samples of macromolecules collected from single-wavelength X-ray diffraction experiments.
John P. Rose, Bi-Cheng Wang, Manfred S. Weiss   +2 more
doaj   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Further Characterization of the Mitigation of Radiation Lethality by Protective Wounding

, 2017
There continues to be a major effort in the United States to develop mitigators for the treatment of mass casualties that received high-intensity acute ionizing radiation exposures from the detonation of an improvised nuclear device during a radiological
Joy Garrett, Katharina Lane, Marc S. Mendonca, Lane, Katharina, Garrett, Joy, Rebecca Joel, Joel, Rebecca, Orschell, Christie M., Christie M. Orschell, Mendonca, Marc S., Joseph R. Dynlacht, Dynlacht, Joseph R.   +11 more
core   +1 more source