Results 111 to 120 of about 3,496 (254)
BMC Medical Imaging, 2019 Purpose The inflammation reaction in the brain may stimulate damage repair or possibly lead to secondary brain injury. It is often associated with activated microglia, which would overexpress 18-kDa translocator protein (TSPO).
Chun-Yi Wu +6 more
doaj +1 more source
The 18F‐Difluoromethyl Group: Challenges, Impact and Outlook
Angewandte Chemie, Volume 136, Issue 26, June 21, 2024.This Minireview summarises the progress radiochemists have made to access the difluoromethyl group in radiolabelled form. Particular attention is given to challenges they have faced, as well as the strategies employed to access this new radiochemical space.
Joseph Ford +2 more
wiley +1 more source
Intestinal absorption of glucose in mice as determined by positron emission tomography. [PDF]
, 2018 KEY POINTS:The goal was to determine the importance of the sodium-glucose cotransporter SGLT1 and the glucose uniporter GLUT2 in intestinal glucose absorption during oral glucose tolerance tests (OGTTs) in mice.
Bindslev +37 more
core +1 more source
Molecules, 2020 [18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS).
Cassis Varlow +7 more
doaj +1 more source
Introduction of Fluorine and Fluorine-Containing Functional Groups [PDF]
, 2013 Over the past decade, the most significant, conceptual advances in the field of fluorination were enabled most prominently by organo- and transition-metal catalysis.
Liang, Theresa +2 more
core +1 more source
Nucleophilic radiofluorination at room temperature via aziridinium intermediates
RSC Adv., 2014 2-Fluoroamines were synthesized at RT from alcohols with different sources of nucleophilic [18F]- or [19F]-fluoride.
Médoc, M, Sobrio, F
openaire +2 more sources
Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor [PDF]
, 2017 P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer’s disease. This study reports the first design, synthesis, radiolabeling and biological evaluation
Gao, Mingzhang +7 more
core +2 more sources
Molecules, 2013 With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [18F]fluorine radiolabeled pyrimidine with 4-hydroxy-3 ...
Simon M. Ametamey +6 more
doaj +1 more source
Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18. [PDF]
Positron emission tomography (PET) is unique in that it allows quantification of biochemical processes in vivo, but difficulties with preparing suitably labelled radiotracers limit its scientific and diagnostic applications.
Cybulska, K +6 more
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